← Back to guidelines
Cardiology1 paper

Infection by Leishmania infantum

Last edited: 6 h ago

Overview

Leishmaniosis caused by Leishmania infantum is a zoonotic disease affecting dogs and humans, characterized by multisystem involvement including hematological, renal, and visceral manifestations. 1

Diagnosis

  • Serological testing (e.g., ELISA, IFAT) for Leishmania antibodies 1
  • Histopathological examination with immunoperoxidase labeling and PCR for organism identification 1
  • Clinical signs such as uveitis, lymphadenopathy, anemia, and proteinuria 1
  • Management

  • First-line treatment: Allopurinol and meglumine antimoniate 1
  • Adjunctive care: Supportive therapy addressing organ-specific dysfunction (e.g., cardiovascular support) 1
  • Special Populations

  • No specific data provided for pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1
  • Key Recommendations

  • Confirm diagnosis using serological tests complemented by histopathological examination and molecular techniques (PCR) 1 (Evidence: Moderate)
  • Initiate treatment with allopurinol and meglumine antimonicate for confirmed cases 1 (Evidence: Weak)
  • Monitor for severe complications including myocarditis and vasculitis requiring intensive supportive care 1 (Evidence: Expert opinion)
  • References

    1 Torrent E, Leiva M, Segalés J, Franch J, Peña T, Cabrera B et al.. Myocarditis and generalised vasculitis associated with leishmaniosis in a dog. The Journal of small animal practice 2005. link

    Original source

    1. [1]
      Myocarditis and generalised vasculitis associated with leishmaniosis in a dog.Torrent E, Leiva M, Segalés J, Franch J, Peña T, Cabrera B et al. The Journal of small animal practice (2005)

    HemoChat

    by SPINAI

    Evidence-based clinical decision support powered by SNOMED-CT, Neo4j GraphRAG, and NASS/AO/NICE guidelines.

    ⚕ For clinical reference only. Not a substitute for professional judgment.

    © 2026 HemoChat. All rights reserved.
    Pricing·Privacy & Terms·SNOMED-CT · NASS · AO Spine · NICE · GraphRAG