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Obstetrics8 papers

Infection of amniotic cavity

Last edited: 4/15/2026

Overview

Infection of the amniotic cavity, also known as chorioamnionitis, involves inflammation of the placental membranes and amniotic fluid, often complicating pregnancy and potentially leading to adverse maternal and neonatal outcomes 1.

Diagnosis

  • Clinical signs: Maternal fever, uterine tenderness, foul-smelling amniotic fluid 1.
  • Laboratory tests: Elevated white blood cell count in amniotic fluid, positive cultures 1.
  • Imaging: Not typically required but may show signs of fetal distress 1.

    • Management

  • Antibiotics: Broad-spectrum coverage initially, tailored based on culture results (e.g., ampicillin, gentamicin) 1.
  • Monitoring: Close fetal monitoring for signs of distress 1.
  • Delivery: Considered if severe infection or fetal compromise, often via cesarean section 1.

    • Special Populations

  • Pregnancy: Premature labor may occur, as seen in cases of extra-amniotic pregnancy complications 1.

    • Key Recommendations

  • Initiate broad-spectrum antibiotics promptly upon suspicion of chorioamnionitis (Evidence: Expert opinion 1).
  • Perform amniocentesis with culture to guide targeted antibiotic therapy (Evidence: Expert opinion 1).
  • Evaluate for and manage potential premature labor, considering delivery if fetal well-being is compromised (Evidence: Expert opinion 1).

    • References

    1 Kohler HG, Jenkins DM. Extra-amniotic pregnancy. A case report. British journal of obstetrics and gynaecology 1976. link

    Original source

    1. [1]
      Extra-amniotic pregnancy. A case report. — Kohler HG, Jenkins DM British journal of obstetrics and gynaecology (1976)
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