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Mild persistent asthma controlled — Clinical Guidelines

Overview

Mild persistent asthma is a chronic inflammatory airway disease characterized by intermittent symptoms and normal lung function between exacerbations. Achieving and maintaining asthma control is crucial for improving quality of life and preventing exacerbations.

Diagnosis

Management

Allergic rhinitis (AR) treatment, including antihistamines and corticosteroids, may improve asthma outcomes in patients with co-existing AR 2.

Leukotriene receptor antagonists (LRAs) have not shown significant improvements from baseline in asthma outcomes 2.

Corticosteroids performed significantly better than LRAs in improving asthma outcomes 2.

Antihistamines and corticosteroids initiated for AR showed a positive effect on asthma outcomes 2.

Special Populations

Pediatrics: Long-term dupilumab treatment reduced exacerbation rates and improved lung function and asthma control in children aged 6-11 years with moderate-to-severe type 2 inflammatory asthma, irrespective of disease severity 1. Children with poorly controlled asthma often have severe or persistent disease 3. Asthma education delivered by community health workers may improve asthma control in children 4.

Key Recommendations

Control of allergic rhinitis symptoms can improve asthma outcomes in patients with co-existing diseases 2.

Antihistamines and corticosteroids used for allergic rhinitis may have a positive effect on asthma outcomes 2.

Leukotriene receptor antagonists have not demonstrated significant improvements in asthma outcomes 2.

References

1 Jackson DJ, Gappa M, Bacharier LB, Deschildre A, Ross K, Xia C et al.. Dupilumab efficacy by disease severity in pediatric type 2 asthma. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2025. link 2 Tameeris E, Bohnen AM, Bindels PJE, Elshout G. The effect of allergic rhinitis treatment on asthma control: a systematic review. NPJ primary care respiratory medicine 2025. link 3 Nakamuta JS, Puglia ALP, Meireles P, Blanco DC, Lima MA, Birck MG et al.. Asthma control in Brazil: a systematic review. The Journal of asthma : official journal of the Association for the Care of Asthma 2023. link 4 Lohr KD, Everhart RS, Holder RL, Boutté R, Corona R, Mazzeo SE. Changes in caregiver mental health and pediatric asthma control during COVID-19. The Journal of asthma : official journal of the Association for the Care of Asthma 2023. link

Mild persistent asthma controlled