Overview
Locally advanced breast cancer (LABC) represents a complex subtype characterized by its aggressive nature and potential for systemic spread, necessitating multidisciplinary management approaches to address both local and metastatic disease 1.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 2712 indexed papers.
1 Garcia-Saenz JA, Lopez-Barajas IB, Echavarria I, Gonzalez CH, Vila MM, Antón FM et al.. SEOM-GEICAM-SOLTI clinical guidelines in advanced breast cancer (UPDATE 2025). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026. link 2 Schiaffino S, Bernardi D, Healy N, Marino MA, Romeo V, Sechopoulos I et al.. ESR Essentials: artificial intelligence in breast imaging-practice recommendations by the European Society of Breast Imaging. European radiology 2026. link 3 . Multimodal AI Model Predicts Breast Cancer Recurrence. Cancer discovery 2026. link 4 Ferrarelli LK. Sense and stromal density. Science signaling 2026. link 5 Rakha EA, Quinn CM, Provenzano E, Pinder SE, Ellis IO. Diagnostic Discordance and Error in Breast Pathology: Causes, Classifications, and Medicolegal Implications. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026. link 6 Alwidyan T, Shamieh O, Al-Talla B, Parsons C, Alarjeh G, Tayyem M et al.. The CoDe/ETHIC-Talk: A theory-informed intervention to support ethical deprescribing in hospice care. Research in social & administrative pharmacy : RSAP 2026. link 7 Zhang M, Kong C, Chen H, Liu H, Li J, Chen Y et al.. Artificial intelligence-driven pharmacovigilance analysis of polypharmacy and adverse events in breast cancer survivors treated with antidepressants. International journal of surgery (London, England) 2026. link 8 Downs G, Greer R, Moses G, Gurgenci T, Good P, Hardy J. Drug Interactions in People on Cannabidiol: Is There Cause for Concern?. Cannabis and cannabinoid research 2026. link 9 Hu X, Jiang C, Kwon Y, Geng F, Fan Q, Shi KS et al.. Medicare Plan Switching and Hospice Care Among Decedents With Advanced Cancer. JAMA network open 2026. link 10 Carmack T. Veterinary Hospice-Enhancing Quality Without Prolonging Suffering. The Veterinary clinics of North America. Small animal practice 2026. link 11 Martinsson L, Brännström M, Fransson P, Andersson S. Palliative medicine physicians' experiences using the Numeric Rating Scale for pain assessment in patients with advanced cancer: a qualitative study. BMJ open 2026. link 12 Makabe H, Narita M, Nagumo Y, Fujiwara M, Hamada Y, Takise J et al.. Pain signaling via sensory neurons drives breast cancer progression through neuropeptide release and κ-opioid counter-regulation. Pharmacological research 2026. link 13 Li X, Yang F, Zhou F, Zhu S, Yuan L, Ma L. Mining and analysis of adverse event signals of trastuzumab deruxtecan via real-world data of FDA adverse event reporting system database from 2019 to 2023. Expert opinion on drug safety 2026. link 14 Wang S, Pan H, Chen Z, Zhou H, Chen J, Zou G et al.. Hematological toxicities in antibody-drug conjugates related with breast cancer: a pharmacovigilance study using FDA adverse event reporting system database. Expert opinion on drug safety 2026. link 15 Qu K, Zhao J, Zhang Y, Li J. Pegylated liposomal doxorubicin-induced hand-foot syndrome in a patient with breast cancer: Case report and FAERS database analysis. International journal of clinical pharmacology and therapeutics 2026. link 16 Luo L, Wang Y, Fu Y, Chen X, Liu S, Zhao B. Comprehensive safety assessment of ribociclib: A real-world analysis using the FDA Adverse Event Reporting System (FAERS) database. British journal of clinical pharmacology 2026. link 17 Deeg J, Swoboda M, Lacaita PG, Barbieri F, Ladenhauf V, Scharll Y et al.. Impact of Radiation Therapy for Breast Cancer on the Coronary Artery Disease Profile at Cardiac CT. Radiology. Cardiothoracic imaging 2026. link 18 Molnar AO, McArthur E, Bota SE, Stirling K, Romain J, Leong DP et al.. Kidney function changes associated with trastuzumab use in women with breast cancer: a retrospective cohort study. Breast cancer research and treatment 2026. link 19 Abrahams C, Zhang W, Sangweni N, Kodogo V, Hadebe N, Okello E et al.. Dysfunctional high-density lipoprotein particles are associated with cardiac alterations in cancer patients and tumor-bearing mice receiving doxorubicin. Basic research in cardiology 2026. link 20 Chia JE, Ang SP, Usman MH, Krittanawong C, Mukherjee D. Trends, Characteristics and Outcomes in Breast Cancer Survivors With STEMI. Angiology 2026. link 21 Izaias JE, Sales AO, Ono BE, Rodrigues TS, Silva GMPS, Pentagna PS et al.. Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy. Journal of the American Heart Association 2026. link 22 Gootzen TA, van Gelder MMHJ, Hermens RPMG, van Bommel MHD, Apperloo MJA, Arts-de Jong M et al.. Development of cardiovascular risk factors in women with a BRCA1/2 pathogenic variant within five years after tubo-ovarian cancer risk reduction in the TUBA study. Maturitas 2026. link 23 Liu Y, Chen B, Li H, Zhang W, Lian B, Huang Z et al.. CPT1A exacerbates trastuzumab-induced cardiotoxicity via promotion of mitochondrial dysfunction. International journal of biological macromolecules 2026. link 24 Eskander Attia M, Abo El-Ela FI, Wali SM, Fouad AG, Belal A, Baali FH et al.. Improving the bioavailability and therapeutic efficacy of valsartan for the control of cardiotoxicity-associated breast cancer. Journal of drug targeting 2026. link 25 Saenger JA, Happe J, Kerber B, Kaim K, Uenal E, Bos D et al.. Breast Arterial Calcifications in Mammography: Evaluating Diagnostic Accuracy, Reproducibility, and Clinical Feasibility of Visual Scoring Systems. Journal of breast imaging 2026. link 26 Linhares BG, Linhares DG, Vale RGS, Gonçalves DM. Time to adopt a new standard method for assessing cardiac function in chemotherapy-induced cardiotoxicity in breast cancer? A systematic review and meta-analysis. Current problems in cardiology 2026. link 27 Hoo YY, Sia WW, Jaya-Prakason S, Koczwara B, Kong YC, Salem JE et al.. Risk of QTc prolongation, and major cardiovascular adverse events associated with CDK4/6 inhibitors in hormone receptor-positive HER2-negative breast cancer - A systematic review and meta-analysis. Cancer treatment reviews 2026. link 28 Zhang D, Huang Y, Li H, Yao Y, Hao M, Liu T. Determinants of cardiovascular health management in patients with breast cancer at high risk for cardiotoxicity: A qualitative study. European journal of oncology nursing : the official journal of European Oncology Nursing Society 2026. link 29 Rahimi Petrudi N, Rahimi Petroudi S, Rajabi MR, Farshidi H, Hassanshahi J. Radiation-induced coronary artery calcification in breast cancer: insights from a systematic review and meta-analysis. Coronary artery disease 2026. link 30 Gentile G, Gerosa R, de Azambuja E, Piccart-Gebhart M. 20th anniversary of adjuvant trastuzumab: reflections on a breakthrough moment. Annals of oncology : official journal of the European Society for Medical Oncology 2026. link 31 Yi JE, Chung WB, Rhu J, Park CS. Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Patients Receiving Combination Therapy of Candesartan and Carvedilol for Primary Prevention: A Prospective Longitudinal Study. Journal of Korean medical science 2026. link 32 Abu Rmilah A, Adham A, Ikram-Ul H, Alzu'bi H, Nandan A, Jouni H et al.. Novel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer. European journal of preventive cardiology 2026. link 33 Yoon H, Kim Y, Han S, Suh HS, Park C. Long-term survival prediction in older women with stage I-II breast cancer using decision tree-based machine learning. Journal of geriatric oncology 2026. link 34 Masum K, Srinivas S, Ramaiah B. Rare manifestation of paclitaxel-induced cardiotoxicity: A case of restrictive cardiomyopathy in an elderly breast cancer patient. Indian journal of pharmacology 2026. link 35 Leitzelar BN, Costa JV, Aguilar AA, Wolle BR, Lucas AR, Marshall A et al.. Qualitative Study of Breast Cancer and Lymphoma Patients Participating in a Physical Activity Intervention: The Case for Tailored Physical Activity. Cancer medicine 2026. link 36 Anker MS, Mahabadi AA, Totzeck M, Tewes M, Khan MS, Mincu RI et al.. Heart failure therapy in patients with advanced cancer receiving specialized palliative care (EMPATICC trial). European heart journal 2026. link 37 Chandrasekaran SH, Inban P, Maharjan R, Faisal AM, Patel VM, Ayirebi-Acquah E et al.. Investigation of chemotherapy-induced cardiac dysfunction in breast cancer. Journal of chemotherapy (Florence, Italy) 2026. link 38 Nakajima E, Nguyen L, Liu N, Rodin D, Amir E, Austin PC et al.. Long-Term Risk of Cardiovascular Disease After Contemporary Left-Sided Breast Radiation Therapy. JAMA network open 2026. link 39 Yu N, Cao B, Yang J, Xu J, Zhang M, Fei X et al.. Mechanism exploration of Salvia miltiorrhiza Bunge against trastuzumab induced cardiotoxicity via multi-omics. Journal of ethnopharmacology 2026. link 40 Pozo-Agundo A, García-Rodríguez S, Antúnez-Rodríguez A, Chica-Redecillas L, Cejas RB, Lyra-Leite D et al.. Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes. European journal of pharmacology 2026. link 41 Liu X, Yin S, Li X, Nie J. Focusing on toxicity management: Challenges and strategies for HER2-targeted antibody-drug conjugates in breast cancer. Breast (Edinburgh, Scotland) 2026. link 42 Yao S, Chua AV, Sheng H, Zimbalist A, Hill JW, Roh JM et al.. Clinically Sufficient Vitamin D Levels With Survival and Cardiovascular Outcomes in a Prospective Cohort of 3,995 Individuals Diagnosed With Invasive Breast Cancer. Journal of the National Comprehensive Cancer Network : JNCCN 2026. link 43 Li Y, Wang S, Zhao X. Risk factors for TIVAD-related venous thrombosis in Chinese breast cancer patients undergoing chemotherapy: A single-center retrospective study. Medicine 2026. link 44 Villani M, Zecca F, Ensle F, Jungblut L, Athanasiou A, Boulet B et al.. The Management of Antithrombotic Therapy in Image-Guided Breast Biopsy: A Systematic Review With Meta-Analysis. Journal of breast imaging 2026. link 45 Toro V, Mougin M, Brossat C, Jambon-Barbara C, Hlavaty A, Guay CA et al.. Breast Cancer Reveals Latent . Circulation 2026. link 46 Huang PL, Mysore MM, Barr B, Onukwugha E. Relationship Between Census Tract-Level Social Determinants of Health and Cardiovascular Care among Individuals Diagnosed With Breast Cancer. Clinical breast cancer 2026. link 47 Moore HCF. Cardiovascular and musculoskeletal health in breast cancer survivors. Maturitas 2026. link 48 Liu Z, Guo S, Xu X, Tang P, Xue H, Long X. A Venous Thromboembolism-Associated Model for Predicting Tumor Microenvironment Features in Breast Cancer. Clinical breast cancer 2026. link 49 Ramin C, Gresham G, Li J, Karlstaedt A, Hashibe M, Nikolova AP et al.. Cardiovascular disease mortality among women diagnosed with de novo metastatic breast cancer. Cancer epidemiology 2026. link 50 Yammani RD, Chen X, Cruz-Diaz N, Zhu X, Basu S, Kim-Shapiro DB et al.. Dietary nitrate and nitrite protect against doxorubicin-induced cardiac fibrosis and oxidative protein damage in tumor-bearing mice. FEBS open bio 2026. link 51 Vo JB, Rosenberg S, Zhang BX, Snow C, Kirkner G, Poorvu PD et al.. Association of cancer treatment with excess heart age among five-year young breast cancer survivors. Journal of cancer survivorship : research and practice 2026. link 52 Park KU, Somerfield MR, Anne N, Brackstone M, Conlin AK, Couto HL et al.. Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2025. link 53 Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D et al.. NCCN Guidelines® Insights: Breast Cancer, Version 5.2025. Journal of the National Comprehensive Cancer Network : JNCCN 2025. link 54 Jimenez RB, Abdou Y, Anderson P, Barry P, Bradfield L, Bradley JA et al.. Postmastectomy Radiation Therapy: An ASTRO-ASCO-SSO Clinical Practice Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2025. link 55 Harborg S, Larsen HB, Elsgaard S, Borgquist S. Metabolic syndrome is associated with breast cancer mortality: A systematic review and meta-analysis. Journal of internal medicine 2025. link 56 Milman R, Bevins NB, Alhamami M, Busse N, Dohatcu A, Hulme KW et al.. AAPM Medical Physics Practice Guideline MPPG 17.a: Quality management for mammography review workstation displays. Journal of applied clinical medical physics 2025. link 57 Jimenez RB, Abdou Y, Anderson P, Barry P, Bradfield L, Bradley JA et al.. Postmastectomy Radiation Therapy: An ASTRO/ASCO/SSO Clinical Practice Guideline. Practical radiation oncology 2025. link 58 Valizadeh P, Jannatdoust P, Moradi N, Yaghoobpoor S, Toofani S, Rafiei N et al.. Ultrasound-based machine learning models for predicting response to neoadjuvant chemotherapy in breast cancer: A meta-analysis. Clinical imaging 2025. link 59 Zambelli A, Gerosa R, Cinquini M, Di Maio M, Miglietta F, Arecco L et al.. The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives. Tumori 2025. link 60 Yeh ED, Brown A, Freer PE, Bahl M, Bennett DL, Darbha L et al.. ACR Appropriateness Criteria® Female Breast Cancer Screening: 2025 Update. Journal of the American College of Radiology : JACR 2025. link 61 Paulis LV, Lewin AA, Weinstein SP, Baron P, Dayaratna S, Dodelzon K et al.. ACR Appropriateness Criteria® Supplemental Breast Cancer Screening Based on Breast Density: 2024 Update. Journal of the American College of Radiology : JACR 2025. link 62 Reimer T, Kuehn T, Mueller V, Ditsch N, Fehm T, Albert US et al.. AGO Breast Commission recommendations for the surgical therapy of breast cancer: Working Group on Gynecologic Cancers (AGO) update 2025. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2025. link 63 Cagnacci A, Villa P, Grassi GP, Biglia N, Gambacciani M, Di Carlo C et al.. Systemic hormone therapy after breast and gynecological cancers: an Italian expert group consensus opinion. Climacteric : the journal of the International Menopause Society 2025. link 64 Ferre R, Kuzmiak CM. Tomosynthesis-only Detected Architectural Distortion: A Meta-analysis of 1361 Lesions. Academic radiology 2025. link 65 Nguyen AT, Li RA, Ontiveros NC, Adam TH, Hansen N, Galiano RD. Utility of the Social Vulnerability Index in Addressing Breast Cancer Disparities: A Meta-Analysis. Journal of surgical oncology 2025. link 66 Salkowski LR, Lewin AA, Weinstein SP, Bartell S, Birsner ML, Borges VF et al.. ACR Appropriateness Criteria® Breast Imaging During Pregnancy. Journal of the American College of Radiology : JACR 2025. link 67 Ferre R, Kuzmiak CM. Malignancy Rates of Pure Radial Scars Detected on Digital Breast Tomosynthesis: A Meta-analysis. Academic radiology 2025. link 68 Freer PE, Neal CH, Brown A, Bennett DL, Cassidy MR, Chetlen A et al.. ACR Appropriateness Criteria® Male Breast Cancer Screening. Journal of the American College of Radiology : JACR 2025. link 69 Izadi Nazar AH, Safari Faramani R, Roushani Roudsari Y, Aghaz F. Are hydrogels suitable for delivery of cisplatin to the microenvironment in breast cancer treatment: a meta-analysis. Therapeutic delivery 2025. link 70 Turnbull C, Achatz MI, Balmaña J, Castro E, Curigliano G, Cybulski C et al.. Breast cancer germline multigene panel testing in mainstream oncology based on clinical-public health utility: ESMO Precision Oncology Working Group recommendations. Annals of oncology : official journal of the European Society for Medical Oncology 2025. link 71 Maloney B, Flannery M, Bischof JJ, Van Allen K, Adeyemi O, Goldfeld KS et al.. Factors impacting loneliness in patients with serious life-limiting illness in the Emergency Medicine Palliative Care Access (EMPallA) study. BMC palliative care 2025. link 72 Foley JF. Making complexes less complicated. Science signaling 2025. link 73 Cleary C. International Society for Exercise Oncology: patient perspective. Journal of the National Cancer Institute. Monographs 2025. link 74 Guinigundo AS. Precision Oncology and the Evolution of Breast Cancer Care. Clinical journal of oncology nursing 2025. link 75 Singh R, Patel K, Xu H, Adeniyi A, Upshaw JN, Van Buren P et al.. Cardio-Oncology and Breast Cancer Therapies. Current treatment options in oncology 2025. link 76 Wallins J, Saravia S, Bolaji O, Shaikh Z, Yu A. Cardio-Oncology Considerations for Breast Cancer: Risk Stratification, Monitoring, and Treatment. Oncology (Williston Park, N.Y.) 2025. link 77 Wernhart S, Fiorentini C, Glowka S, Madl B, Grill S, Kiechle M et al.. Evaluating cardiovascular risk factors in breast cancer survivors: The role of echocardiography and cardiopulmonary exercise testing in the Munich Cardio-Oncology-Exercise retrospective Registry. International journal of cardiology 2025. link 78 O'Dea A, Caulfield R, Roche M. Impact of the Practice Environment on Oncology and Hematology Nurses: A Scoping Review. Cancer nursing 2025. link 79 Zhang H, Huo X, Li J, Li N, Xiao W, Wang M et al.. Mendelian randomization and transcriptomic data analysis reveals the causal association between gout and breast cancer. Medicine 2025. link 80 Barry C, Brodrick R, Gupta G, Panjwani I. Palliative sedation at the end of life: Practical and ethical considerations. Clinical medicine (London, England) 2025. link 81 Mercadante S, Tartaglia L, Cascio AL, Casuccio A. Practice of Palliative Sedation in Patients Followed by a Palliative Home Care Team. Journal of pain and symptom management 2025. link 82 Hanna MG. Digital Pathology and Artificial Intelligence in Breast Pathology. Surgical pathology clinics 2025. link 83 Karakas C, Aldrees RA, Mohamed A, Ellis IO, Fineberg SA, Ngo MH et al.. A Validation Study of an Expanded Description of Glandular (Acinar)/Tubule Formation for the Use of Nottingham Grading System for Invasive Breast Carcinomas Demonstrates Improvement in Concordance for Breast Pathologists and Trainees in Pathology. Archives of pathology & laboratory medicine 2025. link 84 Guidi AJ, Blond BJ, Long TA, Coulter SN, Brown RW. Turnaround Time for Image-Guided Breast Core Biopsies: A College of American Pathologists Q-Probes Study. Archives of pathology & laboratory medicine 2025. link 85 Li Z, King A, Souers RJ, Roberson JJ, Masood S, Alex D et al.. Breast Biomarker Cytology Practice in 2023: Results of a College of American Pathologists Survey. Archives of pathology & laboratory medicine 2025. link 86 Brunyé TT, Shucard H, Eguchi MM, Drew T, Marotti J, Lomo LC et al.. Characterizing Interpretive and Diagnostic Competency Development in Pathology Training. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2025. link 87 Lopes A, Rasmussen S, Djordjevic B, Gomez JA, Mora MF, Sharma A et al.. The Effect of Window Size on Pathologists' Search for Rare Elements in a Digital Pathology Setting. Archives of pathology & laboratory medicine 2025. link 88 Nkya GZ, Omoyiola OZ, Betiku OA, Ng DL, Fernandes FC, Tacula NS et al.. Assessment of Breast Pathology Reporting Needs and Development of Tumor Synoptic Templates in Sub-Saharan Africa. Archives of pathology & laboratory medicine 2025. link 89 Francis J, Baxter M, Giza D, Cheung KL, Parks R. Patient-Reported Outcomes in Geriatric Oncology-Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model. Drugs & aging 2025. link 90 Heudel P, Ahmed M, Renard F, Attye A. Leveraging Digital Twins for Stratification of Patients with Breast Cancer and Treatment Optimization in Geriatric Oncology: Multivariate Clustering Analysis. JMIR cancer 2025. link 91 Brandstetter LS, Grau A, Heuschmann PU, Müller-Reiter M, Salmen J, Störk S et al.. Medication patterns and potentially inappropriate medication in patients with metastatic breast cancer: results of the BRE-BY-MED study. BMC cancer 2025. link 92 Geum MJ, Yoo SH, Lee SW, Hong M, Jung EH, Kim YJ et al.. Impact of CNS medication burden and drug interactions on delirium in patients with advanced cancer: a multicenter prospective observational study. Scientific reports 2025. link 93 Ng HS, Johansen C, Li M, Roder D, Beckmann K, Koczwara B. Patterns of medication use following breast cancer diagnosis: an Australian population-based study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2025. link 94 Briers M, Mylemans M, Tousseyn T, Lai LM, Tajdar M, Van Laer C. Automated feathered edge blood smear analysis: early diagnosis of carcinocythemia in a case of disseminated intravascular coagulation with multi-organ failure. Laboratory medicine 2025. link 95 Crowley PD, Siegel LR, Dickinson DT. Common Antimicrobial Treatment Considerations for Patients Receiving Comfort-Focused Care: What the Hospice Provider Should Know. Journal of palliative medicine 2025. link 96 Xu Q, Zhang X, Liu Y. Effects of hospice care combined with mindfulness-based stress reductiontherapy on negative emotions along with living quality in patients with advanced tumours. JPMA. The Journal of the Pakistan Medical Association 2025. link 97 Ingielewicz A, Brunka Z, Szczupak M, Szymczak RK. Palliative patients who may benefit from intranasal delivery of symptomatic drugs: a two-center observational study evaluated the administration of morphine and dexamethasone in Polish hospices. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2025. link 98 Choi HL, Kim JA, Seo MH, Lee EJ, Heo YJ, Kim KW et al.. Impact of consultation-based hospice palliative care team on self-determination respect rates. Palliative & supportive care 2025. link 99 Gunaga S, Al-Hage A, Buchheister A, Neelam H, Corcoran J, Welchans M et al.. Trends in hospice and palliative care consults initiated in the emergency department: An eight-year utilization analysis. The American journal of emergency medicine 2025. link 100 Carpenter KP, Bellolio F, Ingram C, Klassen AB, McGuire SS, Morgan AA et al.. Characteristics of patients enrolled in hospice presenting to the emergency department. The American journal of emergency medicine 2025. link