Cleft of soft palate and cleft lip

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

Showing 100 most recent of 120 indexed papers.

1 Sharma V, Arora P, Dhiman A, Harish S, Gandhi TK, Dash S. Effectiveness of Telehealth-Based Speech Therapy in Improving Articulation, Resonance, Nasal Emission, and Intelligibility in Children With Repaired Cleft lip and Palate: A Systematic Review. International journal of language & communication disorders 2026. link 2 Ardouin K, Ormond T, Stock N, Macrae P. Combining Speech Language Therapy and Clinical Psychology for Adolescents and Adults With CL/P: A Pilot Clinic in New Zealand. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2026. link 3 Smerica AM, Amer R, Edmonds J, Edmonds JL. Otology and Audiology: Complications, Challenges, and Concerns in the Patient With Cleft Lip and/or Palate. The Journal of craniofacial surgery 2025. link 4 Schaffrath K, Ooms M, Seidel S, Hölzle F, Modabber A. An evaluation of speech therapy care in the surrounding area of an interdisciplinary cleft lip and palate tertiary care center. Scientific reports 2025. link 5 Subramaniyan B, Sell D, Pereira V, Sweeney T, Nagarajan R, Bostock E et al.. Profiling the Roles and Responsibilities of Professionals and Non-Professionals Providing Speech Language Services for Individuals with CLP in Resource-Limited Regions. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025. link 6 Persson C, Davies J, Havstam C, Søgaard H, Bowden M, Boers M et al.. Longitudinal Speech Outcome at 5 and 10 Years in UCLP: Influence of Speech Therapy and Secondary Velopharyngeal Surgery. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025. link 7 Venkatraman K, Prabhu V, Nallamuthu A. Adaptive insights: dynamic assessment for speech sound intervention in a child with cleft lip and palate. BMJ case reports 2025. link 8 Nallamuthu A, Prabhu V, Jayakumar S, Venkatraman K. Remote guidance: enabling tele-supervised community-based rehabilitation worker intervention to facilitate communication in a child with cleft lip and palate. BMJ case reports 2025. link 9 Horne SA, Sommer CL, Crowley CJ. Evaluating the Impact of a Global Cleft Speech Mentorship Program on Expanding Practitioner Competency in Low- and Middle-Income Countries. The Journal of craniofacial surgery 2025. link 10 Moshtaghi Fard Z, Aghadoost S, Moradi N, Sarmadi S, Mohammadi F, Bahrami N. Quality of Life in Adolescents and Young Adults with Cleft Lip and Palate with and Without Speech Therapy During COVID-19. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025. link 11 Sharma RK, Landeen KC, Ortiz A, Belcher RH, Phillips JD, Stephan SJ et al.. National Trends of Otolaryngology Involvement in Cleft Surgical Management over 10-Years. The Laryngoscope 2024. link 12 Verma A, Singh SV, Arya D. Alarm Signals to Postpone Feeding Plate Fabrication and Nasoalveolar Molding. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2023. link 13 Darjazini Nahas L, Hmadieh M, Audeh M, Yousfan A, Almasri IA, Martini N. Cleft lip and palate risk factors among otorhinolaryngology: Head and neck surgery patients in two hospitals. Medicine 2023. link 14 Sangha MS, Kim SJ, St John L, Kahn-Pascual Y, Fell M, Richard B et al.. The CLEFT Student Section: Engaging the future of cleft through fundraising; Structure of the section and results from inaugural year. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2023. link 15 Baigorri M, Crowley CJ, Sommer CL, Moya-Galé G. Barriers and Resources to Cleft Lip and Palate Speech Services Globally: A Descriptive Study. The Journal of craniofacial surgery 2021. link 16 Cheng H, Rao B, Zhang W, Chen R, Peng Y. Increased modularity of the resting-state network in children with nonsyndromic cleft lip and palate after speech rehabilitation. Brain and behavior 2021. link 17 Ghabrial E, Bütow KW, Olorunju S. South African speech-language therapists' opinion of their training in cleft lip and palate and craniofacial deformities. The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings 2020. link 18 Li Z, Zhang W, Li C, Wang M, Wang S, Chen R et al.. Articulation rehabilitation induces cortical plasticity in adults with non-syndromic cleft lip and palate. Aging 2020. link 19 Rao B, Cheng H, Fan Y, Zhang W, Chen R, Peng Y. Topological properties of the resting-state functional network in nonsyndromic cleft lip and palate children after speech rehabilitation. Journal of integrative neuroscience 2020. link 20 Jørgensen LD, Willadsen E. Longitudinal study of the development of obstruent correctness from ages 3 to 5 years in 108 Danish children with unilateral cleft lip and palate: a sub-study within a multicentre randomized controlled trial. International journal of language & communication disorders 2020. link 21 Jiang Y, Bashraheel MK, Liu H, Poelaert J, Van de Velde M, Vandenbroucke G et al.. In vitro efficiency of 16 different Ca(OH). Journal of clinical monitoring and computing 2019. link 22 Hlongwa P, Dandajena TC, Rispel LC. Comparative analysis of healthcare provision to individuals with cleft lip and/or palate at specialised academic centres in South Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2019. link 23 Cox LL, Cox TC, Moreno Uribe LM, Zhu Y, Richter CT, Nidey N et al.. Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate. American journal of human genetics 2018. link 24 Kummer AW. A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. Pediatric clinics of North America 2018. link 25 Scheller K, Quitzke V, Kappler M. New molecular aspects in the mechanism of oromaxillofacial cleft prevention by B-vitamins. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2018. link 26 Sell D, Southby L, Wren Y, Wills AK, Hall A, Mahmoud O et al.. Centre-level variation in speech outcome and interventions, and factors associated with poor speech outcomes in 5-year-old children with non-syndromic unilateral cleft lip and palate: The Cleft Care UK study. Part 4. Orthodontics & craniofacial research 2017. link 27 Zhang W, Li C, Chen L, Xing X, Li X, Yang Z et al.. Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy. Neuroreport 2017. link 28 Ness AR, Wills AK, Mahmoud O, Hall A, Sell D, Smallridge J et al.. Centre-level variation in treatment and outcomes and predictors of outcomes in 5-year-old children with non-syndromic unilateral cleft lip treated within a centralized service: the Cleft Care UK study. Part 6: summary and implications. Orthodontics & craniofacial research 2017. link 29 James JN, Schlieder DW. Prenatal Counseling, Ultrasound Diagnosis, and the Role of Maternal-Fetal Medicine of the Cleft Lip and Palate Patient. Oral and maxillofacial surgery clinics of North America 2016. link 30 Rawal RB, Kilpatrick LA, Wood JS, Drake AF. Trends in medical malpractice claims in patients with cleft or craniofacial abnormalities in the United States. International journal of pediatric otorhinolaryngology 2016. link 31 Sritacha P, Pumnum T, Prathanee B. Speech Correction for Children with Cleft Lip and Palate in Community: Kantharawichai Networking. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2016. link 32 Pradubwong S, Prathanee B, Patjanasoontorn N. Effectiveness of Networking of Khon Kaen University Community-Based Speech Model: Quality of Life. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2016. link 33 Thohinung U, Prathanee B. Caregivers’ Role in Caring for Children with Cleft Lip-Palate in Mobile Speech Camp. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2016. link 34 Mitkitti R, Prathanee B. Caregivers’ Feedback after Enrollment in the Community-Based Speech Therapy Model. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2016. link 35 Feriani G, Hatanaka E, Torloni MR, da Silva EM. Infraorbital nerve block for postoperative pain following cleft lip repair in children. The Cochrane database of systematic reviews 2016. link 36 Pumnum T, Kum-ud W, Prathanee B. A Networking of Community-Based Speech Therapy: Borabue District, Maha Sarakham. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2015. link 37 Pradubwong S, Augsornwan D, Pathumwiwathana P, Prathanee B, Chowchuen B. Empowering Volunteers at Tawanchai Centre for Patients with Cleft Lip and Palate. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2015. link 38 Hanchanlert Y, Pramakhatay W, Pradubwong S, Prathanee B. Speech Correction for Children with Cleft Lip and Palate by Networking of Community-Based Care. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2015. link 39 Burnell L, Verchere C, Pugash D, Loock C, Robertson S, Lehman A. Additional post-natal diagnoses following antenatal diagnosis of isolated cleft lip +/− palate. Archives of disease in childhood. Fetal and neonatal edition 2014. link 40 Capone RB, Butts SC, Jones LR. Starting a cleft team: a primer. Facial plastic surgery clinics of North America 2014. link 41 Scott AR, Nguyen H, Kelly JC, Sidman JD. Prenatal consultation with the pediatric otolaryngologist. International journal of pediatric otorhinolaryngology 2014. link 42 Jahanbin A, Pahlavannezhad MR, Savadi M, Hasanzadeh N. The effect of speech therapy on acoustic speech characteristics of cleft lip and palate patients: a preliminary study. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 2014. link 43 Bautzer AP, Guedes ZC. Verification of the therapeutic process in cleft patients. CoDAS 2014. link 44 Jones T, Al-Ghatam R, Atack N, Deacon S, Power R, Albery L et al.. A review of outcome measures used in cleft care. Journal of orthodontics 2014. link 45 Lee CC, Jagtap RR, Deshpande GS. Longitudinal treatment of cleft lip and palate in developing countries: dentistry as part of a multidisciplinary endeavor. The Journal of craniofacial surgery 2014. link 46 Drake AF, Rosenthal LH. Otolaryngologic challenges in cleft/craniofacial care. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2013. link 47 Calcia A, Gai G, Di Gregorio E, Talarico F, Naretto VG, Migone N et al.. Bilaterally cleft lip and bilateral thumb polydactyly with triphalangeal component in a patient with two de novo deletions of HSA 4q32 and 4q34 involving PDGFC, GRIA2, and FBXO8 genes. American journal of medical genetics. Part A 2013. link 48 Sasor SE, Flores RL, Wooden WA, Tholpady S. The cost of intraoperative plastic surgery education. Journal of surgical education 2013. link 49 Thanawirattananit P, Prathanee B. Audiological findings in cleft lip and palate children attending speech camp. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2013. link 50 Stoel-Gammon C, Williams AL. Early phonological development: creating an assessment test. Clinical linguistics & phonetics 2013. link 51 Madahar A, Murray A, Orr R, Sandler PJ. The long and winding road--the journey of a cleft lip and palate patient part 1. Dental update 2013. link 52 Pereira VJ, Sell D, Tuomainen J. Effect of maxillary osteotomy on speech in cleft lip and palate: perceptual outcomes of velopharyngeal function. International journal of language & communication disorders 2013. link 53 Aziz SR, Ziccardi VB, Chuang SK. Survey of residents who have participated in humanitarian medical missions. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2012. link 54 Friede H, Lilja J, Lohmander A. Long-term, longitudinal follow-up of individuals with UCLP after the Gothenburg primary early veloplasty and delayed hard palate closure protocol: maxillofacial growth outcome. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2012. link 55 Lohmander A, Friede H, Lilja J. Long-term, longitudinal follow-up of individuals with unilateral cleft lip and palate after the Gothenburg primary early veloplasty and delayed hard palate closure protocol: speech outcome. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2012. link 56 Van Lierde KM, Dhaeseleer E, Luyten A, Van De Woestijne K, Vermeersch H, Roche N. Parent and child ratings of satisfaction with speech and facial appearance in Flemish pre-pubescent boys and girls with unilateral cleft lip and palate. International journal of oral and maxillofacial surgery 2012. link 57 Prathanee B, Pumnum T, Jaiyong P, Seepuaham C, Xayasin V. Speech and language therapy model for children with cleft lip/palate in Lao People's Democratic Republic. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2011. link 58 Furr MC, Larkin E, Blakeley R, Albert TW, Tsugawa L, Weber SM. Extending multidisciplinary management of cleft palate to the developing world. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2011. link 59 Waldron JM, Sandy JR, Hewson AR, McNamara CM. Cleft-affected children in Mayo: 1999-2007. Journal of the Irish Dental Association 2011. link 60 Prathanee B, Lorwatanapongsa P, Makarabhirom K, Suphawatjariyakul R, Thinnaithorn R, Thanwiratananich P. Community-based model for speech therapy in Thailand: implementation. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2010. link 61 Ichida M, Komuro Y, Yanai A. Consideration of median cleft lip with frenulum labii superior. The Journal of craniofacial surgery 2009. link 62 Shkalim V, Baris HN, Gal G, Gleiss R, Calderon S, Wessels M et al.. Autosomal dominant syndrome of mental retardation, hypotelorism, and cleft palate resembling Schilbach-Rott syndrome. American journal of medical genetics. Part A 2009. link 63 Tan TY, Amor DJ, Riley M, Halliday J, Kilpatrick N, Simms K et al.. Registry- and clinic-based analyses of birth defects and syndromes associated with cleft lip/palate in Victoria, Australia. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2009. link 64 Reutter H, Birnbaum S, Mende M, de Assis NA, Hoffmann P, Lacava AD et al.. Transforming growth factor-beta receptor type 1 (TGFBR1) is not associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent. International journal of pediatric otorhinolaryngology 2009. link 65 Tindlund RS, Holmefjord A, Eriksson JC, Johnson GE, Vindenes H. Interdisciplinary evaluation of consecutive patients with unilateral cleft lip and palate at age 6, 15, and 25 years: a concurrent standardized procedure and documentation by plastic surgeon; speech and language pathologist; ear, nose, and throat specialist; and orthodontist. The Journal of craniofacial surgery 2009. link 66 Maier A, Hönig F, Bocklet T, Nöth E, Stelzle F, Nkenke E et al.. Automatic detection of articulation disorders in children with cleft lip and palate. The Journal of the Acoustical Society of America 2009. link 67 Lees M. Familial risks of oral clefts. BMJ (Clinical research ed.) 2008. link 68 Smyth AG, Knepil GJ. Prophylactic antibiotics and surgery for primary clefts. The British journal of oral & maxillofacial surgery 2008. link 69 Gregg TA, Leonard AG, Hayden C, Howard KE, Coyle CF. Birth prevalence of cleft lip and palate in Northern Ireland (1981 to 2000). The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2008. link 70 Cole P, Kaufman Y, Hollier L. Bifid nose with cleft hand deformity: syndromic association or undescribed anomaly?. The Journal of craniofacial surgery 2008. link 71 Chuo CB, Searle Y, Jeremy A, Richard BM, Sharp I, Slator R. The continuing multidisciplinary needs of adult patients with cleft lip and/or palate. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2008. link 72 Mueller AA, Sader R, Honigmann K, Zeilhofer HF, Schwenzer-Zimmerer K. Central nervous malformations in presence of clefts reflect developmental interplay. International journal of oral and maxillofacial surgery 2007. link 73 Weingärtner J, Lotz K, Fanghänel J, Gedrange T, Bienengräber V, Proff P. Induction and prevention of cleft lip, alveolus and palate and neural tube defects with special consideration of B vitamins and the methylation cycle. Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie 2007. link 74 van der Veen FJ, van Hagen JM, Berkhof J, Don Griot JP. Regional underreporting of associated congenital anomalies in cleft patients in the Netherlands. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2006. link 75 Cooper ME, Ratay JS, Marazita ML. Asian oral-facial cleft birth prevalence. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2006. link 76 Zhu J, Ren A, Hao L, Pei L, Liu J, Zhu H et al.. Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. American journal of medical genetics. Part A 2006. link 77 Chan RK, McPherson B, Whitehill TL. Chinese attitudes toward cleft lip and palate: effects of personal contact. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2006. link 78 De Mey A, Swennen G, Malevez C, George M, Mansbach AL. Long-term follow-up of UCLP at the Reine Fabiola Children's Hospital. B-ENT 2006. link 79 Prathanee B, Dechongkit S, Manochiopinig S. Development of community-based speech therapy model: for children with cleft lip/palate in northeast Thailand. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2006. link 80 Payne AS, Yan AC, Ilyas E, Li W, Seykora JT, Young TL et al.. Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. Archives of dermatology 2005. link 81 King NM, Cheong CH, Sanares AM. Van der Woude syndrome: a report of two cases. The Journal of clinical pediatric dentistry 2004. link 82 Sha'ban RI, Asfour WM. Cleft lip and palate with ectopia lentis et pupillae. Saudi medical journal 2003. link 83 Pfeifer TM, Grayson BH, Cutting CB. Nasoalveolar molding and gingivoperiosteoplasty versus alveolar bone graft: an outcome analysis of costs in the treatment of unilateral cleft alveolus. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2002. link 84 Zanzi M, Cherpillod J, Hohlfeld J. Phonetic and otological results after early palate closure in 18 consecutive children presenting with cleft lip and palate. International journal of pediatric otorhinolaryngology 2002. link00235-5) 85 Schubert J, Schmidt R, Syska E. B group vitamins and cleft lip and cleft palate. International journal of oral and maxillofacial surgery 2002. link 86 Punjabi AP, Thaller SR. New directions in the management of cleft lip. Clinics in plastic surgery 2001. link 87 Jeffery SL, Boorman JG. Patient satisfaction with cleft lip and palate services in a regional centre. British journal of plastic surgery 2001. link 88 Pulkkinen J, Haapanen ML, Laitinen J, Paaso M, Ranta R. Association between velopharyngeal function and dental-consonant misarticulations in children with cleft lip/palate. British journal of plastic surgery 2001. link 89 Sell D, Grunwell P, Mildinhall S, Murphy T, Cornish TA, Bearn D et al.. Cleft lip and palate care in the United Kingdom--the Clinical Standards Advisory Group (CSAG) Study. Part 3: speech outcomes. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2001. link 90 Murray JC. Time for T. Nature genetics 2001. link 91 Stoll C, Dott B, Alembik Y, Roth M. Evaluation of prenatal diagnosis of cleft lip/palate by foetal ultrasonographic examination. Annales de genetique 2000. link00011-3) 92 Steinwachs EF, Amos C, Johnston D, Mulliken J, Stal S, Hecht JT. Nonsyndromic cleft lip and palate is not associated with cancer or other birth defects. American journal of medical genetics 2000. link1096-8628(20000103)90:1<17::aid-ajmg4>3.0.co;2-9) 93 Tanabe A, Taketani S, Endo-Ichikawa Y, Tokunaga R, Ogawa Y, Hiramoto M. Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people. Clinical science (London, England : 1979) 2000. link 94 Cooper ME, Stone RA, Liu Y, Hu DN, Melnick M, Marazita ML. Descriptive epidemiology of nonsyndromic cleft lip with or without cleft palate in Shanghai, China, from 1980 to 1989. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2000. link 95 Carmichael SL, Shaw GM. Maternal corticosteroid use and risk of selected congenital anomalies. American journal of medical genetics 1999. link1096-8628(19990917)86:3<242::aid-ajmg9>3.0.co;2-u) 96 Milerad J, Larson O, Hagberg C, Ideberg M. Associated malformations in infants with cleft lip and palate: a prospective, population-based study. Pediatrics 1997. link 97 Murray JC, Daack-Hirsch S, Buetow KH, Munger R, Espina L, Paglinawan N et al.. Clinical and epidemiologic studies of cleft lip and palate in the Philippines. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 1997. link 98 Ishizawa Y, Handa Y, Tanaka K, Taki K. General anaesthesia for cleft lip and palate surgery team activities in Cambodia. Tropical doctor 1997. link 99 FitzPatrick DR, Raine PA, Boorman JG. Facial clefts in the west of Scotland in the period 1980-1984: epidemiology and genetic diagnoses. Journal of medical genetics 1994. link 100 O'Gara MM, Logemann JA, Rademaker AW. Phonetic features by babies with unilateral cleft lip and palate. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 1994. link