Overview
Benign mesothelial proliferation with effusion is a clinicopathologic entity characterized by non-malignant proliferation of mesothelial cells often associated with pleural effusion. Despite its benign nature, it can mimic metastatic papillary adenocarcinoma both grossly and microscopically, complicating diagnosis and management 1.Diagnosis
Clinical Presentation: Effusion and potential involvement of multiple body cavities over variable intervals 1.
Imaging: Chest imaging (CT, MRI) to assess effusion and potential extrapleural involvement 1.
Pathology: Histopathology distinguishing benign proliferation from malignancy; immunohistochemical markers may aid in differentiation 1.
Cytology: Pleural fluid analysis to rule out malignant cells 1.Management
Surgical Intervention: Pericardectomy may be required in cases of pericardial tamponade 1.
Symptomatic Treatment: Management of symptoms such as pain and respiratory distress 1.
Monitoring: Regular follow-up to assess for recurrence or progression 1.Special Populations
Pregnancy: No specific data provided in the abstracts 1.
Pediatrics: No specific data provided in the abstracts 1.
Elderly: No specific considerations noted in the abstracts 1.
Comorbidities: Management may need adjustment based on coexisting conditions, though specific guidance is not provided 1.Key Recommendations
Distinguish benign mesothelial proliferation with effusion from malignant conditions through comprehensive histopathologic evaluation and immunohistochemical analysis (Evidence: Moderate 1).
Consider surgical intervention such as pericardectomy for complications like pericardial tamponade (Evidence: Weak 1).
Implement close monitoring and symptomatic treatment to manage clinical course effectively (Evidence: Expert opinion 1).References
1 Hansen RM, Caya JG, Clowry LJ, Anderson T. Benign mesothelial proliferation with effusion. Clinicopathologic entity that may mimic malignancy. The American journal of medicine 1984. link90531-x)