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Allergy & Immunology4 papers

Verrucous hyperplasia of oral mucosa

Last edited: 4/15/2026

Overview

Verrucous hyperplasia of oral mucosa, often associated with denture use, is a benign fibrous overgrowth characterized by excessive proliferation of connective tissue 1. It typically occurs in the maxillary labial mucosa adjacent to denture borders and can lead to discomfort and functional impairment 1.

Diagnosis

  • Clinical presentation includes a firm, well-demarcated, hyperplastic mass 1.
  • Histopathology confirms the presence of dense fibrous connective tissue without atypia 1.
  • Digital image analysis and immunocytochemistry may aid in understanding histopathogenesis 1.

    • Management

  • Surgical excision: Primary treatment for definitive removal 1.
  • Conservative methods: Use of soft lining materials to reduce pressure and facilitate shrinkage 1.
  • Combined approach: Surgical excision followed by conservative management to prevent recurrence 1.

    • Special Populations

  • Denture wearers: Particularly susceptible; management focuses on denture adjustments and material changes 1.
  • No specific guidance provided for pregnancy, pediatrics, or elderly populations in the given abstracts 1.

    • Key Recommendations

  • Consider conservative management with soft denture liners to reduce pressure and promote shrinkage (Evidence: Moderate 1).
  • Surgical excision is recommended for definitive treatment and to prevent recurrence (Evidence: Expert opinion 1).
  • Combine surgical removal with conservative measures for optimal outcomes (Evidence: Expert opinion 1).

    • References

    1 Thomas GA. Denture-induced fibrous inflammatory hyperplasia (epulis fissuratum): research aspects. Australian prosthodontic journal 1993. link

    Original source

    1. [1]
      Denture-induced fibrous inflammatory hyperplasia (epulis fissuratum): research aspects. — Thomas GA Australian prosthodontic journal (1993)
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