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Endocrinology27 papers

Acquired hypothyroidism

Last edited: 4/10/2026

Overview

Hypothyroidism is a condition characterized by insufficient production of thyroid hormones by the thyroid gland. It has multiple etiologies and can manifest in various ways, influencing patient quality of life 12.

Diagnosis

  • Evaluation includes clinical and laboratory assessment 2.
  • Thyroid function tests, including thyrotropin (TSH) and free thyroxine (FT4), are used 1.
  • Subclinical and overt hypothyroidism are defined based on laboratory values 1.

    • Management

  • Appropriate treatment requires accurate diagnosis and is influenced by coexisting medical conditions 2.
  • Guidelines address the management of hypothyroidism in ambulatory patients 2.
  • Screening and treatment of subclinical hypothyroidism are covered 2.

    • Key Recommendations

  • Hypothyroidism and TSH levels influence the risk of genetically predicted benign prostatic hyperplasia (BPH) and prostatitis 1.
  • Evidence-based clinical guidelines exist for the clinical management of hypothyroidism in ambulatory patients 2.
  • Guidelines address screening, treatment of subclinical hypothyroidism, and management during pregnancy 2.

    • References

    1 Huang Y, Chen C, Zhou W, Zhang Q, Zhao Y, He D et al.. Genetically predicted alterations in thyroid function are associated with the risk of benign prostatic disease. Frontiers in endocrinology 2023. link 2 Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al.. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012. link

    Original source

    1. [1]
      Genetically predicted alterations in thyroid function are associated with the risk of benign prostatic disease. — Huang Y, Chen C, Zhou W, Zhang Q, Zhao Y, He D et al. Frontiers in endocrinology (2023)
    2. [2]
      Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. — Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (2012)
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