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Rehabilitation14 papers

Granuloma of vocal cords

Last edited: 4/15/2026

Overview

Vocal process granuloma is a benign lesion affecting the vocal cords, often associated with factors such as laryngopharyngeal reflux, laryngeal intubation, and vocal abuse. Its etiology is not fully understood, leading to varied treatment approaches and outcomes. 1

Diagnosis

  • Clinical Presentation: Typically identified through hoarseness and endoscopic visualization of a lesion at the vocal process.
  • Associated Factors: Commonly linked to laryngopharyngeal reflux, laryngeal intubation, and vocal misuse. 1
  • Diagnostic Tests: Endoscopy is essential for visualization; pH monitoring may help identify reflux as an underlying cause. 1
  • Management

  • First-Line Treatments:
  • - Proton Pump Inhibitors (PPIs): Used to manage laryngopharyngeal reflux. 1 - Topical Inhalant Steroids: To reduce inflammation. 1 - Phonotherapy: Voice therapy aimed at modifying vocal fold contact patterns. 2
  • Adjunctive Treatments:
  • - Surgical Removal: Effective in 90% of cases when combined with clinical management. 1 - Voice Conservation and Hygiene: Essential components of voice therapy programs. 2

    Special Populations

  • No Specific Guidance: The provided abstracts do not offer detailed recommendations for pregnancy, pediatrics, elderly patients, or specific comorbidities. 12
  • Key Recommendations

  • Combine Medical Management with Phonotherapy: Initiate treatment with PPIs and topical inhalant steroids alongside phonotherapy to address underlying causes and modify vocal behaviors. (Evidence: Moderate 12)
  • Consider Surgical Intervention for Persistent Lesions: If medical and phonotherapy approaches fail, surgical removal of the granuloma can be highly effective. (Evidence: Moderate 1)
  • Long-Term Management of Etiological Factors: Continue management of reflux or other contributing factors beyond the initial treatment period to prevent recurrence. (Evidence: Weak 1)
  • References

    1 Lemos EM, Sennes LU, Imamura R, Tsuji DH. Vocal process granuloma: clinical characterization, treatment and evolution. Brazilian journal of otorhinolaryngology 2005. link31205-2) 2 Leonard R, Kendall K. Effects of voice therapy on vocal process granuloma: a phonoscopic approach. American journal of otolaryngology 2005. link

    Original source

    1. [1]
      Vocal process granuloma: clinical characterization, treatment and evolution.Lemos EM, Sennes LU, Imamura R, Tsuji DH Brazilian journal of otorhinolaryngology (2005)
    2. [2]
      Effects of voice therapy on vocal process granuloma: a phonoscopic approach.Leonard R, Kendall K American journal of otolaryngology (2005)

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