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Psychiatry23 papers

Atrophy of cortex of frontal lobe

Last edited: 4/10/2026

Overview

Frontal lobe cortical atrophy refers to a reduction in the thickness of the cerebral cortex in the frontal lobe. This finding has been observed in various neurological and psychiatric conditions.

Diagnosis

Management

Special Populations

Key Recommendations

  • Patients with schizophrenia show decreased cortical thickness in the right inferior frontal gyrus and bilateral insula extending to the superior temporal gyrus 1.
  • Patients with chronic schizophrenia exhibit decreased cortical thickness in the right insula extending to the right inferior frontal gyrus 1.
  • No significant cortical thickness difference was found between first-episode patients with schizophrenia and healthy controls 1.

    • References

    1 Sun S, Xiao S, Guo Z, Gong J, Tang G, Huang L et al.. Meta-analysis of cortical thickness reduction in adult schizophrenia. Journal of psychiatry & neuroscience : JPN 2023. link

    Original source

    1. [1]
      Meta-analysis of cortical thickness reduction in adult schizophrenia. — Sun S, Xiao S, Guo Z, Gong J, Tang G, Huang L et al. Journal of psychiatry & neuroscience : JPN (2023)
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