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Psychiatry95 papers

Atrophy of hippocampus

Last edited: 4/10/2026

Overview

The hippocampal formation is a key region implicated in the pathophysiology of schizophrenia 1. Aerobic exercise is being investigated as a potential adjunctive treatment to counteract structural impairments of the hippocampal formation 1.

Management

  • Aerobic exercise did not demonstrate a significant effect on total hippocampal formation volume in people with schizophrenia in a meta-analysis 1.
  • Further exploration of aerobic exercise effects on hippocampal formation subfield volumes is warranted 1.
  • Key Recommendations

  • Aerobic exercise did not show a significant effect on total hippocampal formation volume in people with schizophrenia 1. (Evidence: Strong)
  • Focusing on hippocampal formation subfields is important for understanding the pathophysiology of schizophrenia 1. (Evidence: Expert opinion)
  • References

    1 Roell L, Fischer T, Keeser D, Papazov B, Lembeck M, Papazova I et al.. Effects of aerobic exercise on hippocampal formation volume in people with schizophrenia - a systematic review and meta-analysis with original data from a randomized-controlled trial. Psychological medicine 2024. link

    Original source

    1. [1]

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