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Pathology79 papers

Disease caused by Human bocavirus

Last edited: 4/14/2026

Overview

Human bocavirus (HBoV) is a parvovirus that primarily affects the respiratory and gastrointestinal tracts, causing respiratory and enteric infections, particularly in young children. No specific antiviral medication is available, and management focuses on supportive care 1.

Diagnosis

  • Clinical Presentation: Common symptoms include cough, rhinorrhea, fever, and gastrointestinal disturbances.
  • Laboratory Tests: Detection of HBoV DNA in nasopharyngeal or stool samples via PCR is crucial for diagnosis 1.
  • Imaging: Chest X-rays may show nonspecific respiratory tract involvement in severe cases 1.
  • Management

  • Supportive Care: Focus on hydration, fever management, and symptomatic relief 1.
  • Monitoring: Close observation for complications, especially in immunocompromised individuals 1.
  • Special Populations

  • Pediatrics: HBoV infections are predominantly seen in young children, necessitating careful monitoring for complications 1.
  • Immunocompromised Individuals: Require heightened vigilance due to potential for more severe disease 1.
  • Key Recommendations

  • Diagnose HBoV infections primarily through PCR detection of viral DNA in respiratory or stool samples (Evidence: Moderate 1).
  • Prioritize supportive care measures including hydration and symptom management (Evidence: Expert opinion 1).
  • Enhance monitoring in pediatric and immunocompromised populations due to higher risk of complications (Evidence: Expert opinion 1).
  • References

    1 Ahmad S, Ali SS, Iqbal A, Ali S, Hussain Z, Khan I et al.. Using a dual immunoinformatics and bioinformatics approach to design a novel and effective multi-epitope vaccine against human torovirus disease. Computational biology and chemistry 2024. link 2 Köhler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA et al.. The Human Phenotype Ontology in 2021. Nucleic acids research 2021. link 3 Lee LY, Loscalzo J. Network Medicine in Pathobiology. The American journal of pathology 2019. link 4 Ernst PB, Carvunis AR. Of mice, men and immunity: a case for evolutionary systems biology. Nature immunology 2018. link 5 Levin IW, Bhargava R. Fourier transform infrared vibrational spectroscopic imaging: integrating microscopy and molecular recognition. Annual review of physical chemistry 2005. link 6 O'Neil BJ, Kline JA, Burkhart K, Younger J. Research fundamentals: V. The use of laboratory animal models in research. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1999. link 7 Hoffman HM, Irwin AE, Baird S, Bloor CM, Miyai K, Savoia MC. UCSD's MedPics: implementation and impact on the curriculum. Proceedings. Symposium on Computer Applications in Medical Care 1993. link 8 DeLellis RA, Wolfe HJ. New techniques in gene product analysis. Archives of pathology & laboratory medicine 1987. link

    Original source

    1. [1]
      Using a dual immunoinformatics and bioinformatics approach to design a novel and effective multi-epitope vaccine against human torovirus disease.Ahmad S, Ali SS, Iqbal A, Ali S, Hussain Z, Khan I et al. Computational biology and chemistry (2024)
    2. [2]
      The Human Phenotype Ontology in 2021.Köhler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA et al. Nucleic acids research (2021)
    3. [3]
      Network Medicine in Pathobiology.Lee LY, Loscalzo J The American journal of pathology (2019)
    4. [4]
      Of mice, men and immunity: a case for evolutionary systems biology.Ernst PB, Carvunis AR Nature immunology (2018)
    5. [5]
    6. [6]
      Research fundamentals: V. The use of laboratory animal models in research.O'Neil BJ, Kline JA, Burkhart K, Younger J Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (1999)
    7. [7]
      UCSD's MedPics: implementation and impact on the curriculum.Hoffman HM, Irwin AE, Baird S, Bloor CM, Miyai K, Savoia MC Proceedings. Symposium on Computer Applications in Medical Care (1993)
    8. [8]
      New techniques in gene product analysis.DeLellis RA, Wolfe HJ Archives of pathology & laboratory medicine (1987)

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