Overview
Choroid plexus carcinoma is a rare and aggressive neoplasm arising from the choroid plexus, typically found in the ventricular system of the brain, with the fourth ventricle being a common location 1.Diagnosis
Imaging: Preoperative T2-weighted MRI often shows diffuse high-intensity lesions, particularly in the brain stem and fourth ventricle floor infiltration 1.
CT Findings: Useful for distinguishing between various choroid plexus lesions, including papillomas, carcinomas, meningiomas, and vascular malformations 2.
Lesion Types: Includes primary neoplasms (papillomas, carcinomas, meningiomas, astrocytomas, teratocarcinomas) and vascular lesions (cavernous angiomas, hemangiomas, arteriovenous malformations) 23.Management
Surgical Resection: Primary treatment; total resection is challenging due to brain stem infiltration and fourth ventricle floor involvement, often resulting in incomplete removal 1.
Radiation Therapy: Recommended post-surgery for choroid plexus carcinomas to prevent progression 1.
Control of Intraoperative Bleeding: Effective use of cauterization of feeding arteries through telovelar approach 1.Special Populations
No Specific Guidance: Abstracts do not provide detailed management insights for pregnancy, pediatrics, elderly, or specific comorbidities 123.Key Recommendations
Surgical intervention is indicated for choroid plexus carcinomas, though total resection may be limited by tumor infiltration into critical brain structures (Evidence: Moderate 1).
Postoperative radiation therapy should be considered for patients with choroid plexus carcinomas to reduce the risk of recurrence (Evidence: Moderate 1).
Utilize advanced imaging techniques (MRI, CT) for accurate diagnosis and assessment of lesion extent and type (Evidence: Moderate 23).References
1 Kumabe T, Fujimura M, Jokura H, Tominaga T. Surgical treatment for choroid plexus tumors in the fourth ventricle: brain stem infiltration hinders total extirpation. Neurosurgical review 2008. link
2 Zimmerman RA, Bilaniuk LT. Computed tomography of choroid plexus lesions. The Journal of computed tomography 1979. link90001-8)
3 Carleton CC, Cauthen JC. Vascular ("arteriovenous") malformations of the choroid plexus. Archives of pathology 1975. link