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Hematology488 papers

Leukemia

Last edited: 4/23/2026

Overview

Leukemia is a group of hematologic malignancies characterized by the uncontrolled proliferation of abnormal white blood cells, affecting both lymphoid and myeloid lineages. These disorders can significantly impact patient outcomes and require multidisciplinary management approaches 1 15 37.

Diagnosis

Clinical Presentation: Symptoms include fatigue, recurrent infections, bleeding, and bone pain.

Laboratory Tests: Complete blood count (CBC) often reveals cytopenias or leukocytosis with abnormal cell morphology.

Bone Marrow Aspiration and Biopsy: Essential for definitive diagnosis, assessing blast cell percentage, and guiding treatment 49.

Flow Cytometry and Cytogenetics: Used to identify specific leukemia subtypes and genetic abnormalities 1 15.

Imaging: Useful for assessing organ involvement and complications 20.

Management

First-Line Treatments:

- Chemotherapy: Varies by subtype (e.g., ALL: vincristine, prednisone, daunorubicin; AML: cytarabine, daunorubicin) 1 5 37. - Targeted Therapies: Venetoclax for specific genetic mutations (e.g., FLT3 inhibitors in AML) 21 56.

Adjunctive Treatments:

- Supportive Care: Management of infections, anemia, thrombocytopenia, and managing side effects like cardiotoxicity from doxorubicin 5 28. - Stem Cell Transplantation: Considered for high-risk or relapsed cases 30 50.

Pain and Symptom Management: Use of analgesics and antidepressants for pain and fatigue in elderly patients 13.

Special Populations

Pediatrics:

- Unique Considerations: Hyperleukocytosis requires prompt management; play therapy can improve quality of life 22 24. - Procedural Sedation: Thiamylal plus pentazocine shows efficacy compared to ketamine plus midazolam 66.

Elderly:

- Comorbidities: Increased risk of cardiotoxicity; careful monitoring of doxorubicin dosing and effects 5 28.

Comorbidities:

- Immune-Mediated Risks: Higher risk of severe sepsis during treatment; air purification strategies may reduce infection risk 20 27.

Key Recommendations

Genetic Testing for Risk Stratification: Incorporate genetic variants like those in SLC28A3 and lncRNA SLC28A3-AS1 to tailor doxorubicin dosing and reduce cardiotoxicity (Evidence: Moderate) 5.

Regular Bone Marrow Smear Review: Ensure pathologist review of flagged samples to improve diagnostic accuracy and patient management (Evidence: Moderate) 8.

AI and Digital Imaging in Diagnostics: Utilize AI-powered auto-classification and digital imaging for enhanced accuracy and efficiency in hematology testing (Evidence: Moderate) 7 17.

Supportive Care for Symptom Management: Implement pharmacological interventions for pain and fatigue, particularly in elderly patients, using analgesics and antidepressants (Evidence: Moderate) 13.

Monitor and Manage Cardiotoxicity: Closely monitor patients receiving anthracyclines like doxorubicin for signs of cardiotoxicity and adjust dosing based on genetic markers (Evidence: Moderate) 5.

References

Showing 100 most recent of 465 indexed papers.

1 Caiado F, Manz MG. Genetic resistance to leukemia. Science (New York, N.Y.) 2026. link 2 Canè S, Bronte V. The sialic shield of leukemia cells. Science (New York, N.Y.) 2026. link 3 Cooper J. Enzyme therapy in a structural light. IUCrJ 2026. link 4 Mondal H, Mondal S. HIMO 1.0: an educational game for teaching white blood cell identification by morphology in black and white. Advances in physiology education 2026. link 5 Agrawal S, Das MK, Kaur T, Lokupathirage SMW, Reilly C, Yarram M et al.. Cardioprotective SNPs in SLC28A3 and lncRNA SLC28A3-AS1 result in transcriptional changes and alternative splicing to reduce doxorubicin cytotoxicity. Human molecular genetics 2026. link 6 Gallant R, Reza S, Wiemels JL, Greaves M. Microbiome and pediatric leukemia, diabetes, and allergies: Systematic review and meta-analysis. PloS one 2025. link 7 Nozaka H, Okuse H, Nakata A, Kushibiki M, Ogasawara S, Ishiyama M et al.. AI-Powered Auto-Classification of Blood Cells in Bone Marrow Smear Testing. Studies in health technology and informatics 2025. link 8 Winther-Larsen A, Vestergaard EM, Abildgaard A. Clinical value of smear review of flagged samples analyzed with the Sysmex XN hematology analyzer. Clinical chemistry and laboratory medicine 2025. link 9 Joosse HJ, Chumsaeng-Reijers C, Huisman A, Hoefer IE, van Solinge WW, Haitjema S et al.. Haematology dimension reduction, a large scale application to regular care haematology data. BMC medical informatics and decision making 2025. link 10 Hsu LC, Tsai TH, Lin YH, Lu KY, Liu WC. Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency. Journal of clinical laboratory analysis 2025. link 11 Squillaci D, Console K, Colussi L, Kiren V, Rabusin M, Stocco G et al.. Dexmedetomidine Versus Midazolam for Propofol Sparing in Procedural Sedation of Children With Leukemia: A Consecutive Case Series. Acta anaesthesiologica Scandinavica 2025. link 12 Nakashima MO, Coulter SN, Blond BJ, Brown RW, Vos JA. The Impact of Pathologist Review on Peripheral Blood Smears: A College of American Pathologists Q-Probes Study of 22 Laboratories. Archives of pathology & laboratory medicine 2025. link 13 Li Q, Sun X. Pharmacological interventions for pain and fatigue management in elderly leukemia patients: A comparative study of analgesic and antidepressant efficacy. Pakistan journal of pharmaceutical sciences 2025. link 14 Bastos Silveira B, Di Carvalho Melo L, Amorim Dos Santos J, Ferreira EB, Reis PED, De Luca Canto G et al.. Oral manifestations in pediatric patients with leukemia: A systematic review and meta-analysis. Journal of the American Dental Association (1939) 2024. link 15 Zangooie A, Tavoosi S, Arabhosseini M, Halimi A, Zangooie H, Baghsheikhi AH et al.. Ubiquitin-specific proteases (USPs) in leukemia: a systematic review. BMC cancer 2024. link 16 Bowers KA, Nakashima MO. Digital Imaging and AI Pre-classification in Hematology. Clinics in laboratory medicine 2024. link 17 Kim H, Hur M, Yi JH, Lee GH, Lee S, Moon HW et al.. Detection of blasts using flags and cell population data rules on Beckman Coulter DxH 900 hematology analyzer in patients with hematologic diseases. Clinical chemistry and laboratory medicine 2024. link 18 Jiang H, Xu W, Chen W, He J, Jiang H, Mao Z et al.. Performance of the digital cell morphology analyzer MC-100i in a multicenter study in tertiary hospitals in China. Clinica chimica acta; international journal of clinical chemistry 2024. link 19 Cheng W, Liu J, Wang C, Jiang R, Jiang M, Kong F. Application of image recognition technology in pathological diagnosis of blood smears. Clinical and experimental medicine 2024. link 20 Goggin KP, Lu L, Lee DE, Howell CR, Srivastava D, Brinkman TM et al.. Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. JAMA network open 2024. link 21 Kt MF, Semwal M, Yoosuf BT, Lad D, Bansal D. Venetoclax adverse event monitoring: a safety meta-analysis of randomized controlled trials and a retrospective evaluation of the FAERS. Annals of hematology 2024. link 22 Venglar O, Kapustova V, Anilkumar Sithara A, Zihala D, Muronova L, Sevcikova T et al.. Insight into the mechanism of CD34. British journal of haematology 2024. link 23 Ramdaniati S, Lismidiati W, Haryanti F, Sitaresmi MN. The effectiveness of play therapy in children with leukemia: A systematic review. Journal of pediatric nursing 2023. link 24 Yang Y, Yu C, Fu R, Xia S, Ni H, He Y et al.. Association of cesarean section with risk of childhood leukemia: A meta-analysis from an observational study. Hematological oncology 2023. link 25 Khongjaroensakun N, Chaothai N, Chamchomdao L, Suriyachand K, Paisooksantivatana K. White blood cell differentials performance of a new automated digital cell morphology analyzer: Mindray MC-80. International journal of laboratory hematology 2023. link 26 Chase ML, Drews R, Zumberg MS, Ellis LR, Reid EG, Gerds AT et al.. Consensus recommendations on peripheral blood smear review: defining curricular standards and fellow competency. Blood advances 2023. link 27 Friese C, Breuckmann K, Hüttmann A, Eisele L, Dührsen U. Neutropenia-related aspergillosis in non-transplant haematological patients hospitalised under ambient air versus purified air conditions. Mycoses 2023. link 28 Gándara-Mireles JA, Lares-Asseff I, Reyes Espinoza EA, Fierro IV, Castañeda VL, Cordova Hurtado LP et al.. Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2023. link 29 Walsh MF. Toward more streamlined testing in pediatric oncology. Science advances 2022. link 30 Duzgol M, Boncuoglu E, Kiymet E, Akaslan Kara A, Erdem M, Odaman Al I et al.. Evaluation for Metastatic Candida Focus and Mortality at Candida-associated Catheter-related Bloodstream Infections at the Pediatric Hematology-oncology Patients. Journal of pediatric hematology/oncology 2022. link 31 Bishop E, Miller C, Miller S, McKellar C. How staying in a single room affects the experiences of haematology inpatients in an Australian cancer hospital. British journal of nursing (Mark Allen Publishing) 2022. link 32 Peter Nonkes LJ, de Haas V, Kemperman H, Huisman A, Antonius Musson RE, Groenestege WMT. Evaluation and management of leukolysis-mediated pseudohyperkalemia in paediatric leukemic samples. Biochemia medica 2022. link 33 Mc Dermott S, Dargan C, Gonzalez Dominguez E, Music Aplenc L, Flatt T, Iqbal N. Therapeutic plasma exchange for multiorgan dysfunction among critically ill pediatric patients with leukemia: A single-institutional experience. Journal of clinical apheresis 2022. link 34 Bekmez S, Eris D. Retinal arterial macroaneurysm in leukemia. European journal of ophthalmology 2022. link 35 Zhang WT, Zhang GX, Gao SS. The Potential Diagnostic Accuracy of Circulating MicroRNAs for Leukemia: A Meta-Analysis. Technology in cancer research & treatment 2021. link 36 Daneshdoost SM, El Abiad JM, Ruble KJ, Jones LC, Crane JL, Morris CD et al.. Bisphosphonate Therapy for Treating Osteonecrosis in Pediatric Leukemia Patients: A Systematic Review. Journal of pediatric hematology/oncology 2021. link 37 Lin X, Wang J, Huang X, Wang H, Li F, Ye W et al.. Global, regional, and national burdens of leukemia from 1990 to 2017: a systematic analysis of the global burden of disease 2017 study. Aging 2021. link 38 Ruiz-Argüelles GJ, Gómez-Almaguer D. PERSPECTIVES IN DIAGNOSIS AND THERAPEUTICS IN HEMATOLOGY. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 2021. link 39 . ASH 2020 Insights on Leukemia: An Interview with Dr. Andrew Brunner. The oncologist 2021. link 40 Landgren O, Maura F. Familial patterns of hematologic precursors. Blood 2021. link 41 Bethuel NW, Bravin E, Krupa N, Jenkins P, Scribani M, Gadomski A. Bone marrow biopsy and aspiration: a departmental financial comparison in a rural hospital. BMC research notes 2021. link 42 Kristinsdottir I, Haraldsson A, Gudlaugsson O, Thors V. Low Risk of Central Line-associated Bloodstream Infections in Pediatric Hematology/Oncology Patients. The Pediatric infectious disease journal 2021. link 43 Querol S, Rubinstein P, Madrigal A. The wider perspective: cord blood banks and their future prospects. British journal of haematology 2021. link 44 Al-Dulaimi K, Banks J, Nugyen K, Al-Sabaawi A, Tomeo-Reyes I, Chandran V. Segmentation of White Blood Cell, Nucleus and Cytoplasm in Digital Haematology Microscope Images: A Review-Challenges, Current and Future Potential Techniques. IEEE reviews in biomedical engineering 2021. link 45 Koff A, Burns R, Auerbach M, Lee B, Pearce J, Ciener D et al.. Pediatric Emergency Medicine Didactics and Simulation (PEMDAS) Telesimulation Series: Hyperleukocytosis. MedEdPORTAL : the journal of teaching and learning resources 2021. link 46 Lazăr DR, Farcaş AD, Blag C, Neaga A, Zdrenghea MT, Căinap C et al.. Cardiotoxicity: A Major Setback in Childhood Leukemia Treatment. Disease markers 2021. link 47 Grines CL, Cox D. Can percutaneous coronary interventions be performed safely in leukemia patients?. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2020. link 48 Grever MR. Clara D. Bloomfield, M.D. (1942-2020): Legacy in Leukemia Research. The oncologist 2020. link 49 Bienzle D. Bone Marrow Examination: Why, How, and What to Expect from the Pathologist. The Veterinary clinics of North America. Equine practice 2020. link 50 Konuma T, Kanda J, Inamoto Y, Hayashi H, Kobayashi S, Uchida N et al.. Improvement of early mortality in single-unit cord blood transplantation for Japanese adults from 1998 to 2017. American journal of hematology 2020. link 51 Potts J, Mohamed MO, Lopez Mattei JC, Iliescu CA, Konopleva M, Rashid M et al.. Percutaneous coronary intervention and in-hospital outcomes in patients with leukemia: a nationwide analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2020. link 52 Sandre M, Osmond A, Ghazarian D, Ghiasi N. Bullous leukemia cutis: a rare clinical subtype. Dermatology online journal 2019. link 53 Slim CL, Wevers BA, Demmers MWHJ, Lakos G, Hoffmann JJML, Adriaansen HJ et al.. Multicenter performance evaluation of the Abbott Alinity hq hematology analyzer. Clinical chemistry and laboratory medicine 2019. link 54 Paridaens H, Sabor L, Simar J, Ronez E, Cornet E, Defour JP. Can the 72-hour rule based on "Blast/Abn Lymph" flag on Sysmex XN-10 optimize the workflow in hematology laboratory?. Annales de biologie clinique 2019. link 55 Petrone J, Jackups R, Eby CS, Shimer G, Anderson J, Frater JL. Blast flagging of the Sysmex XN-10 hematology analyzer with supervised cell image analysis: Impact on quality parameters. International journal of laboratory hematology 2019. link 56 Zheng Y, Feng W, Wang YJ, Sun Y, Shi G, Yu Q. Galectins as potential emerging key targets in different types of leukemia. European journal of pharmacology 2019. link 57 Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V et al.. Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. Journal of experimental & clinical cancer research : CR 2019. link 58 Patel A, Joong A, Lelkes E, Gossett JG. Should Physicians Offer a Ventricular Assist Device to a Pediatric Oncology Patient With a Poor Prognosis?. AMA journal of ethics 2019. link 59 Nachmias B, Schimmer AD. Metabolic Flexibility in Leukemia-Adapt or Die. Cancer cell 2018. link 60 Tamplin OJ. Chewing through Roots: How Leukemia Invades and Disrupts the Bone Marrow Microenvironment. Cell stem cell 2018. link 61 . R-2HG Targets FTO to Increase m. Cancer discovery 2018. link 62 . SETD1A Interacts with Cyclin K to Promote Leukemia Cell Survival. Cancer discovery 2018. link 63 Hemmelgarn C. Seeking Answers, Hearing Silence. Health affairs (Project Hope) 2018. link 64 Moretto A, Zanella A, Ciceri V, Rota M, Scaravilli V, Beltrama V et al.. Induction Dosage of Propofol for Repeated Sedations in Children With Hematological Disorders. Journal of pediatric hematology/oncology 2018. link 65 Grunwell JR, Long LD, Bryan LN, Kelley T, Sabnis HS, Simon HK et al.. Factors affecting same-day cancelation of outpatient pediatric oncologic procedural sedation. Pediatric hematology and oncology 2018. link 66 Nakagawa S, Okamoto Y, Kodama Y, Nishikawa T, Tanabe T, Kawano Y. Thiamylal Plus Pentazocine Shows Similar Efficacy as Ketamine Plus Midazolam for Painful Procedures in Children With Leukemia. Journal of pediatric hematology/oncology 2018. link 67 LeBlanc TW, Egan PC, Olszewski AJ. Transfusion dependence, use of hospice services, and quality of end-of-life care in leukemia. Blood 2018. link 68 Reich-Slotky R, Cushing MM, Hsu YS, Ancharski M, Rojas JM, Scrimenti LM et al.. Validating and implementing the use of an infusion pump for the administration of thawed hematopoietic progenitor cells-a single-institution experience. Transfusion 2018. link 69 Park G, Shayani S, Stiller T, Wang S, Yuan S. Dose capping of plerixafor in patients weighing more than 100 kg at one vial led to successful mobilization outcomes and significant cost savings. Transfusion 2018. link 70 Bauters T, Buts S, Bordon V, Laureys G. Drug-drug interaction related to the use of pipamperon and ondansetron in a child treated for leukemia. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2018. link 71 Sunagawa K, Uchino Y, Ishimoto S, Nakamura S, Honma T, Nakanishi Y et al.. Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium. Pathology international 2018. link 72 Frljak S, Jaklic M, Zemljic G, Cerar A, Poglajen G, Vrtovec B. CD34. Stem cells translational medicine 2018. link 73 Fischer S. Sniffing for Cancer : Nano Noses Hold Promise for Detecting Lung Cancer and Other Diseases. IEEE pulse 2017. link 74 Wood KC. Suppressing oncogenic transcription with a little healthy competition. Science translational medicine 2017. link 75 Wright B, Forbes K. Haematologists' perceptions of palliative care and specialist palliative care referral: a qualitative study. BMJ supportive & palliative care 2017. link 76 Buoro S, Mecca T, Seghezzi M, Manenti B, Azzarà G, Dominoni P et al.. Analytical comparison between two hematological analyzer systems: CAL-8000 vs. XN-9000. International journal of laboratory hematology 2017. link 77 Maxwell RR, Egan-Sherry D, Gill JB, Roth ME. Management of chemotherapy-induced febrile neutropenia in pediatric oncology patients: A North American survey of pediatric hematology/oncology and pediatric infectious disease physicians. Pediatric blood & cancer 2017. link 78 Johnson LM, Frader J, Wolfe J, Baker JN, Anghelescu DL, Lantos JD. Palliative Sedation With Propofol for an Adolescent With a DNR Order. Pediatrics 2017. link 79 Duran-Frigola M, Siragusa L, Ruppin E, Barril X, Cruciani G, Aloy P. Detecting similar binding pockets to enable systems polypharmacology. PLoS computational biology 2017. link 80 Friedman DN, Hilden P, Moskowitz CS, Suzuki M, Boulad F, Kernan NA et al.. Cardiovascular Risk Factors in Survivors of Childhood Hematopoietic Cell Transplantation Treated with Total Body Irradiation: A Longitudinal Analysis. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017. link 81 Adashek J. Inside Out. The oncologist 2016. link 82 Thorne SH. Virus fuels NK cell killing of leukemia. Blood 2016. link 83 Seegmiller AC, Kim AS, Mosse CA, Shaver AC, Thompson MA, Li S et al.. Data-Driven Iterative Refinement of Bone Marrow Testing Protocols Leads to Progressive Improvement in Cytogenetic and Molecular Test Utilization. American journal of clinical pathology 2016. link 84 Grzybowski A, Polak A, Kazalo T, Sak J, Jonska-Szuszkiewicz K. Zygmunt Kramsztyk (1849-1920) - the most outstanding medical philosopher among Polish ophthalmologists of the 19th and 20th centuries. Klinika oczna 2016. link 85 Talcott KE, Garg RJ, Garg SJ. Ophthalmic manifestations of leukemia. Current opinion in ophthalmology 2016. link 86 Kemp PS. The best of the best: a review of select pediatric ophthalmology and strabismus case reports published in 2015. Digital journal of ophthalmology : DJO 2016. link 87 Damasceno de Souza A, Barcellos Almeida M. Textual Definitions in the Leukemia Domain: Methodological Guidelines for Biomedical Ontologies. Studies in health technology and informatics 2015. link 88 Chantepie SP, Mear JB, Guittet L, Dervaux B, Marolleau JP, Jardin F et al.. Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial. Trials 2015. link 89 Tian X, Yang YH, Wei HY, Lao JQ, Wang HP, Tian YY. Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children. Genetics and molecular research : GMR 2015. link 90 Moorman AV. Does TP53 guard ALL genomes?. Blood 2014. link 91 Eilertsen H, Hagve TA. Do the flags related to immature granulocytes reported by the Sysmex XE-5000 warrant a microscopic slide review?. American journal of clinical pathology 2014. link 92 Pophali PA, Klotz JK, Ito S, Jain NA, Koklanaris E, Le RQ et al.. Male survivors of allogeneic hematopoietic stem cell transplantation have a long term persisting risk of cardiovascular events. Experimental hematology 2014. link 93 Keser I, Suyani E, Yosmaoglu HB, Aki SZ, Turkoz Sucak AG. Acute physiological responses to physiotherapy applications pre and post autologous stem cell transplantation: an experimental study. Hematology (Amsterdam, Netherlands) 2014. link 94 Zappolo K, DeFeo D, Dang D, Covino J. How to recognize and treat childhood leukemia. JAAPA : official journal of the American Academy of Physician Assistants 2013. link 95 Burger JA. Osteopontin: an unhealthy sleep remedy for ALL. Blood 2013. link 96 Witter K, Albert T, Spannagl M, Dick A. B07:156, revealed by sequence-based typing of a leukemia patient and confirmed by allele-specific amplification. Tissue antigens* 2013. link 97 Gounari F, Kee BL. Fingerprinting ikaros. Nature immunology 2013. link 98 Witter K, Kutsch M, Spannagl M, Dick A. A novel HLA-A allele, A66:17 was revealed in a family of a leukemia patient during high-resolution HLA typing. Tissue antigens* 2013. link 99 Deetz CO, Scott MG, Ladenson JH, Seyoum M, Hassan A, Kreisel FH et al.. Use of a United States-based laboratory as a hematopathology reference center for a developing country: logistics and results. International journal of laboratory hematology 2013. link 100 Hotton J, Broothaers J, Swaelens C, Cantinieaux B. Performance and abnormal cell flagging comparisons of three automated blood cell counters: Cell-Dyn Sapphire, DxH-800, and XN-2000. American journal of clinical pathology 2013. link

Original source

[1]
Genetic resistance to leukemia. — Caiado F, Manz MG Science (New York, N.Y.) (2026)
[2]
The sialic shield of leukemia cells. — Canè S, Bronte V Science (New York, N.Y.) (2026)
[3]
Enzyme therapy in a structural light. — Cooper J IUCrJ (2026)
[4]
HIMO 1.0: an educational game for teaching white blood cell identification by morphology in black and white. — Mondal H, Mondal S Advances in physiology education (2026)
[5]
Cardioprotective SNPs in SLC28A3 and lncRNA SLC28A3-AS1 result in transcriptional changes and alternative splicing to reduce doxorubicin cytotoxicity. — Agrawal S, Das MK, Kaur T, Lokupathirage SMW, Reilly C, Yarram M et al. Human molecular genetics (2026)
[6]
Microbiome and pediatric leukemia, diabetes, and allergies: Systematic review and meta-analysis. — Gallant R, Reza S, Wiemels JL, Greaves M PloS one (2025)
[7]
AI-Powered Auto-Classification of Blood Cells in Bone Marrow Smear Testing. — Nozaka H, Okuse H, Nakata A, Kushibiki M, Ogasawara S, Ishiyama M et al. Studies in health technology and informatics (2025)
[8]
Clinical value of smear review of flagged samples analyzed with the Sysmex XN hematology analyzer. — Winther-Larsen A, Vestergaard EM, Abildgaard A Clinical chemistry and laboratory medicine (2025)
[9]
Haematology dimension reduction, a large scale application to regular care haematology data. — Joosse HJ, Chumsaeng-Reijers C, Huisman A, Hoefer IE, van Solinge WW, Haitjema S et al. BMC medical informatics and decision making (2025)
[10]
Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency. — Hsu LC, Tsai TH, Lin YH, Lu KY, Liu WC Journal of clinical laboratory analysis (2025)
[11]
Dexmedetomidine Versus Midazolam for Propofol Sparing in Procedural Sedation of Children With Leukemia: A Consecutive Case Series. — Squillaci D, Console K, Colussi L, Kiren V, Rabusin M, Stocco G et al. Acta anaesthesiologica Scandinavica (2025)
[12]
The Impact of Pathologist Review on Peripheral Blood Smears: A College of American Pathologists Q-Probes Study of 22 Laboratories. — Nakashima MO, Coulter SN, Blond BJ, Brown RW, Vos JA Archives of pathology & laboratory medicine (2025)
[13]
Pharmacological interventions for pain and fatigue management in elderly leukemia patients: A comparative study of analgesic and antidepressant efficacy. — Li Q, Sun X Pakistan journal of pharmaceutical sciences (2025)
[14]
Oral manifestations in pediatric patients with leukemia: A systematic review and meta-analysis. — Bastos Silveira B, Di Carvalho Melo L, Amorim Dos Santos J, Ferreira EB, Reis PED, De Luca Canto G et al. Journal of the American Dental Association (1939) (2024)
[15]
Ubiquitin-specific proteases (USPs) in leukemia: a systematic review. — Zangooie A, Tavoosi S, Arabhosseini M, Halimi A, Zangooie H, Baghsheikhi AH et al. BMC cancer (2024)
[16]
Digital Imaging and AI Pre-classification in Hematology. — Bowers KA, Nakashima MO Clinics in laboratory medicine (2024)
[17]
Detection of blasts using flags and cell population data rules on Beckman Coulter DxH 900 hematology analyzer in patients with hematologic diseases. — Kim H, Hur M, Yi JH, Lee GH, Lee S, Moon HW et al. Clinical chemistry and laboratory medicine (2024)
[18]
Performance of the digital cell morphology analyzer MC-100i in a multicenter study in tertiary hospitals in China. — Jiang H, Xu W, Chen W, He J, Jiang H, Mao Z et al. Clinica chimica acta; international journal of clinical chemistry (2024)
[19]
Application of image recognition technology in pathological diagnosis of blood smears. — Cheng W, Liu J, Wang C, Jiang R, Jiang M, Kong F Clinical and experimental medicine (2024)
[20]
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. — Goggin KP, Lu L, Lee DE, Howell CR, Srivastava D, Brinkman TM et al. JAMA network open (2024)
[21]
Venetoclax adverse event monitoring: a safety meta-analysis of randomized controlled trials and a retrospective evaluation of the FAERS. — Kt MF, Semwal M, Yoosuf BT, Lad D, Bansal D Annals of hematology (2024)
[22]
Insight into the mechanism of CD34 — Venglar O, Kapustova V, Anilkumar Sithara A, Zihala D, Muronova L, Sevcikova T et al. British journal of haematology (2024)
[23]
The effectiveness of play therapy in children with leukemia: A systematic review. — Ramdaniati S, Lismidiati W, Haryanti F, Sitaresmi MN Journal of pediatric nursing (2023)
[24]
Association of cesarean section with risk of childhood leukemia: A meta-analysis from an observational study. — Yang Y, Yu C, Fu R, Xia S, Ni H, He Y et al. Hematological oncology (2023)
[25]
White blood cell differentials performance of a new automated digital cell morphology analyzer: Mindray MC-80. — Khongjaroensakun N, Chaothai N, Chamchomdao L, Suriyachand K, Paisooksantivatana K International journal of laboratory hematology (2023)
[26]
Consensus recommendations on peripheral blood smear review: defining curricular standards and fellow competency. — Chase ML, Drews R, Zumberg MS, Ellis LR, Reid EG, Gerds AT et al. Blood advances (2023)
[27]
Neutropenia-related aspergillosis in non-transplant haematological patients hospitalised under ambient air versus purified air conditions. — Friese C, Breuckmann K, Hüttmann A, Eisele L, Dührsen U Mycoses (2023)
[28]
Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia. — Gándara-Mireles JA, Lares-Asseff I, Reyes Espinoza EA, Fierro IV, Castañeda VL, Cordova Hurtado LP et al. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2023)
[29]
Toward more streamlined testing in pediatric oncology. — Walsh MF Science advances (2022)
[30]
Evaluation for Metastatic Candida Focus and Mortality at Candida-associated Catheter-related Bloodstream Infections at the Pediatric Hematology-oncology Patients. — Duzgol M, Boncuoglu E, Kiymet E, Akaslan Kara A, Erdem M, Odaman Al I et al. Journal of pediatric hematology/oncology (2022)
[31]
How staying in a single room affects the experiences of haematology inpatients in an Australian cancer hospital. — Bishop E, Miller C, Miller S, McKellar C British journal of nursing (Mark Allen Publishing) (2022)
[32]
Evaluation and management of leukolysis-mediated pseudohyperkalemia in paediatric leukemic samples. — Peter Nonkes LJ, de Haas V, Kemperman H, Huisman A, Antonius Musson RE, Groenestege WMT Biochemia medica (2022)
[33]
Therapeutic plasma exchange for multiorgan dysfunction among critically ill pediatric patients with leukemia: A single-institutional experience. — Mc Dermott S, Dargan C, Gonzalez Dominguez E, Music Aplenc L, Flatt T, Iqbal N Journal of clinical apheresis (2022)
[34]
Retinal arterial macroaneurysm in leukemia. — Bekmez S, Eris D European journal of ophthalmology (2022)
[35]
The Potential Diagnostic Accuracy of Circulating MicroRNAs for Leukemia: A Meta-Analysis. — Zhang WT, Zhang GX, Gao SS Technology in cancer research & treatment (2021)
[36]
Bisphosphonate Therapy for Treating Osteonecrosis in Pediatric Leukemia Patients: A Systematic Review. — Daneshdoost SM, El Abiad JM, Ruble KJ, Jones LC, Crane JL, Morris CD et al. Journal of pediatric hematology/oncology (2021)
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