Epidemiology
In Germany, 68% of patients infected with T. quinckeanum were female, and 43% were children and adolescents (≤ 19 years of age) [PMID:29314679].
Cats were identified as a frequent source of infection for T. quinckeanum strains isolated from human patients [PMID:29314679].
Diagnosis
Given the challenges in unequivocally identifying T. quinckeanum morphologically, molecular techniques such as PCR ELISA, gene sequencing, and MALDI-TOF mass spectrometry are crucial for accurate diagnosis [PMID:29314679].
Management
The compound 2j demonstrated significant antifungal activity against various dermatomycosis-causing fungi, including resistant strains, with promising selectivity and minimal toxicity [PMID:31657052].
Scanning electron microscopy confirmed that compound 2j disrupts fungal cell wall integrity and specifically inhibits pseudohyphae formation in Candida albicans and biofilm formation in Microsporum canis [PMID:31657052].
Special Populations
Preclinical tests indicated that compound 2j is non-irritant and safe for topical application, as it did not cause histopathological changes in pig ear skin models [PMID:31657052].
References
1 Flores Dalla Lana D, Neiva Lavorato S, Minussi Giuliani L, Cruz L, Lopes W, Henning Vainstein M et al.. Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3-bis(3,4-dichlorophenoxy)propan-2-aminium chloride. Mycoses 2020. link 2 Uhrlaß S, Schroedl W, Mehlhorn C, Krüger C, Hubka V, Maier T et al.. Molecular epidemiology of Trichophyton quinckeanum - a zoophilic dermatophyte on the rise. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2018. link
2 papers cited of 3 indexed.