Overview
Multiple sclerosis (MS) in pediatric patients presents as a rare but serious condition characterized by demyelination and neurological dysfunction, often with distinct clinical features compared to adult MS. Early diagnosis and management are crucial to mitigate long-term disability 2131.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 876 indexed papers.
1 Moreira DC, Antillón-Klussmann F, Rosado R, Garrido C, González-Ramella O, Salceda-Rivera V et al.. Building Pediatric Hematology/Oncology Workforce Capacity in Latin America. Pediatric blood & cancer 2026. link 2 van der Zwan YG, van Wijngaard-de Vugt C, Abu-Libdeh A, Kalaitzoglou E, Karabouta Z, Drop SLS et al.. Global Learner Feedback on Continuing Medical Education-Accredited e-Learning Modules in Pediatric Endocrinology and Diabetes: Cross-Sectional Study. JMIR medical education 2026. link 3 Starnes JR, Gandhi R, Armsby LB, Carter KA, Frank LH, Zyblewski SC. Current State of Research Training in Pediatric Cardiology Fellowship Programs. Pediatric cardiology 2026. link 4 Remick KE, Foster AA, Jensen AR, Williams RF, Stone E, Joseph M et al.. Pediatric Readiness in the Emergency Department: Policy Statement. Annals of emergency medicine 2026. link 5 Sheridan N, Robinson A, Masud F, de Schaetzen C, Tse S. Are Health Equity Rounds an Acceptable Format to Address Education on Implicit Bias and Structural Racism in Pediatric Emergency Settings?: A Mixed-Methods Study. Pediatric emergency care 2026. link 6 Leung J, Lue Tam S, Nagji A, Foohey S, Fayyaz J. VRR-CPD: adapting free and open-access distance simulation for the continuing interprofessional education of community emergency department providers on caring for children with acute emergencies. CJEM 2026. link 7 Lenglart L, Lun T, Cantais A, Chappuy H, Dubos F, Escoda S et al.. Tailoring POCUS training to local needs: a context-adapted curriculum for pediatric emergency medicine in France. European journal of pediatrics 2026. link 8 Ramirez R, Blumstein M, Lowe D, Lozano JM, Peña BG. The Effect of a Rapid Assessment Team on Pediatric Emergency Medicine Department Operations and Throughput. Pediatric emergency care 2026. link 9 Bindi JM, Robbins SL, Nelson CJ, Packwood EA. Medical Student Awareness of Pediatric Ophthalmology as a Potential, Future Vocation. Journal of pediatric ophthalmology and strabismus 2026. link 10 Bhettay A, Parker R, Maswime S, Korsah EK, Cunningham C, Trifa M et al.. Exploring Barriers and Facilitators to Incorporating New Practices and Innovations in the Pediatric Perioperative Ecosystem in Sub-Saharan Africa: A Mixed Methods Study. Paediatric anaesthesia 2026. link 11 Rosenbloom E, Aviv G, Schujovizky D, Friedman N. Safety profile of midazolam for minimal sedation in the pediatric emergency department. CJEM 2026. link 12 Obara S, Nakata Y. Cost-effectiveness analysis of sedation regimens for children undergoing magnetic resonance imaging in Japan: a simulation-based study. Journal of anesthesia 2026. link 13 Marso KDS, Peng J, Meyer BD, Azadani E, Amini H, Casamassimo P. Assessing Pediatric Sedation Using Patient-Centered Outcomes. Anesthesia progress 2026. link 14 Barat A, Wojtanowski A, Behal H, Flocteil M, Leteurtre S, De Jonckheere J et al.. Evaluation of the Analgesia Nociception Index (ANI) as an indicator of discomfort in deeply sedated, prepubescent patients. Journal of clinical monitoring and computing 2026. link 15 McGuire A, Rusch R. The Implementation of Memory-Making Kits for Families Enrolling in Home Hospice; A Pilot Program Aimed to Address Parental Grief. Journal of palliative medicine 2026. link 16 Fuentes S, Vicente-Sánchez N, Margarit-Estragués N, Flores-Villar S, Pérez-Poquet M, Gasca-Pera S et al.. Analysis of gas embolism in pediatric laparoscopy: incidence, risk factors, and preventive strategies. Surgical endoscopy 2026. link 17 Williams S, Serhan O, Wang J, Guindi C, Guadagno E, Trudeau M et al.. The impact of gender on pediatric surgical access and outcomes in Africa. Pediatric surgery international 2025. link 18 Roush K. U.S. EDs Fail to Meet Criteria for Pediatric Readiness. The American journal of nursing 2025. link 19 Kelleher ST, Kyle WB, Penny DJ, Olsen J, Nolke L, Allen HD et al.. Twinning International Pediatric Cardiology Fellowship Programs: A Transformative Educational Experience for Trainees with Potential for Global Adoption. Pediatric cardiology 2025. link 20 Rajapuram N, Tandel MD, Tawfik D, Weng Y, Rassbach CE, Purkey NJ. Actionable Areas of Distress Among Pediatric Cardiology Fellows. The Journal of pediatrics 2025. link 21 Karnik R, Robinson B, Glickstein J, Schwartz A, Mink R, Neal AE et al.. Minimum Supervision Levels Required for Pediatric Cardiology Fellowship Graduation by Pediatric Cardiology Fellowship Program Directors. Pediatric cardiology 2025. link 22 Amicucci M, Resente F, Mampieri M, Facciolo V, Partel MC, Bergadano A et al.. Clinical Trial Nurses in Centers of the Italian Association of Pediatric Hematology and Oncology (AIEOP): A Multicenter Observational Study. Pediatric blood & cancer 2025. link 23 Pais P, Lanewala AA, Levy C, Wightman A. Responding to ethical dilemmas in pediatric nephrology: a framework for clinicians in varied practice settings. Pediatric nephrology (Berlin, Germany) 2025. link 24 Attridge MM, Kester KM, Kemal S, Varma Thomas S, Mangold K, Hoffmann JA. Development and Evaluation of an Advocacy Curriculum for Pediatric Emergency Medicine Fellows. Pediatrics 2025. link 25 Wright C, Clark C, Jeong H, Gillespie J, Stanley R, Melvin J. Improving Mass Casualty Incident Preparedness of Pediatric Emergency Medicine Fellows: A Quality Improvement Initiative. Disaster medicine and public health preparedness 2025. link 26 Bray-Aschenbrenner A, Wiltrakis SM. The Influence of Social Media on Pediatric Emergency Medicine Fellowship Applicant Recruitment. Pediatric emergency care 2025. link 27 Tilley H, Enderby A, VanWert E, Choi S. Trends in pediatric emergency medicine: Focus on behavioral health, substance use, and safety. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2025. link 28 Kishida M, Kubo T, Nishisaki A, Ohta K. Comparison of Learning Experience With On-Site Versus Off-Site Telesimulation for Medical Students in Pediatric Emergency Care. Pediatric emergency care 2025. link 29 Rose J, Chong A, McKinley K, Meckler G, Van Rooij T, Görges M et al.. Developing the Standardized Workload Assessment Metric for Pediatric Emergency Departments: Initial Steps Using a Modified Delphi Method. Pediatric emergency care 2025. link 30 Chamberlain J, Kuppermann N, Nigrovic LE, Craig S, Yock-Corrales A, Babl FE et al.. Variation in Availability and Ability to Share Data in a Global Pediatric Emergency Medicine Research Network. Pediatric emergency care 2025. link 31 Rose E, Easter JS. Pediatric emergency 2024 updates. The American journal of emergency medicine 2025. link 32 Gotewal S, Feng SY, Bansal BBC, Nesiama JA. Does Virtual Interviewing Provide the Information for a Satisfactory Rank Decision?: A Perspective From the Pediatric Emergency Medicine Fellowship Interviews. Pediatric emergency care 2025. link 33 Dong Y, Hoffmann B, Schwarz S, Nourkami-Tutdibi N, Huang YL, Chen S et al.. An [illustrative] update on pediatric emergency medicine ultrasound: part 2 - abdominal and urogenital applications. Medical ultrasonography 2025. link 34 Rosenbloom E, Feldman O, Jacob R, Chayen G, Capua T, Takagi D et al.. Establishment of a Mandatory National Simulation Program for Pediatric Emergency Medicine Fellowship Training. Pediatric emergency care 2025. link 35 Fogelson EC, Klinger JA, Cain M, Mullan AF, Nestler DM, Bellolio F et al.. Utilization of emergency medicine telehealth support for pediatric patients in community emergency departments. The American journal of emergency medicine 2025. link 36 AlGoraini Y, Alsayyali M, Alotaibi O, Almeshawi I, Alaifan F, Alrashed R. Perceptions of large language models in medical education and clinical practice among pediatric emergency physicians in Saudi Arabia: a multiregional cross-sectional study. Frontiers in public health 2025. link 37 Baker ACL, Monuteaux MC, Mullan PC, Nagler J, Dorney K. Simulation-Based Training in Clinical Event Debriefing Improves Leadership Performance. Pediatric emergency care 2025. link 38 Jackson J, Chumpitazi CE, Hsu D, Baluyot M, Barrick L, Feng SY et al.. Show Me the Money: A Movement Towards Transparency in Pediatric Emergency Medicine Compensation. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2025. link 39 Ugwu CV, Jergel A, Murray B, Rees CA, Jain S. Clinical Practice Guideline Development in Pediatric Emergency Medicine Departments Across the United States: A Cross-sectional Study. Pediatric emergency care 2025. link 40 Penda CI, Eposse Ekoube C, Mbono Betoko R, Nlend C, Eyoum Bilé B, Ateba Ndongo F et al.. Deferred recovery of health expenditures for pediatric life-threatening emergencies in a resource-limited setting: Alternative before achieving universal health coverage in Cameroon in Central Africa. PloS one 2025. link 41 Ramgopal S, Kemal S, Attridge MM, Crowe R, Martin-Gill C, Macy ML. Comparison of Neighborhood Disadvantage Indices on Emergency Medical Services Interventions and Outcomes for Pediatric Out-of-Hospital Emergencies. Academic pediatrics 2025. link 42 Morehead LC, Duffy EK, Boos MD. Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications. Pediatric dermatology 2025. link 43 Martz N, Lachkar AA, Breaud J, Ali L, Pierucci UM, Talon I et al.. The influence of positive and negative intraoperative feedback in laparoscopic simulation in pediatric urology training. Journal of pediatric urology 2025. link 44 Teplitsky SL, Spencer KA, Edwins R, Robinson LE, Robinson CM, Becerra AZ et al.. Disruptive papers - A novel bibliometric tool not yet ready for primetime in pediatric urology. Journal of pediatric urology 2025. link 45 Lin M, Bradfield Y, Soni A, Nallasamy S, Nguyen A. The timing and impact of factors influencing the pursuit of pediatric ophthalmology fellowship training. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2025. link 46 Rudd Zhong Manis J, Bicknell BT, Chishom H, Heo Y, Dzubinski L, Liang A et al.. Examining key factors on the road to leadership positions among pediatric ophthalmology faculty. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2025. link 47 Adhan IK, Sussberg RM, Nelson LB, Lee KE, Lam L. Analyzing Trends in the Pediatric Ophthalmology Workforce From 2016 to 2024. Journal of pediatric ophthalmology and strabismus 2025. link 48 Lam L, Nelson LB, Vagge A, Nucci P, Lembo A, Sussberg JA et al.. A Comparative Analysis of the Economic and Workforce Issues in Pediatric Ophthalmology in Italy and the United States Post-Pandemic. Journal of pediatric ophthalmology and strabismus 2025. link 49 Webb L, Masaracchia M, Strupp K. Enhancing Access to Neuraxial Ultrasound Phantoms for Medical Education of Pediatric Anesthesia Trainees: Tutorial. JMIR medical education 2025. link 50 Carullo P, Khan S, Nause-Osthoff R, Gupta R, Xie J, Azamfirei R et al.. Understanding Pediatric Anesthesiology Fellowship Interest: A National Survey of the Resident Experience. Paediatric anaesthesia 2025. link 51 Ferschl MB, Hoagland M, Nasr VG, Staffa SJ, Infosino A. Virtual or In-Person Conferences? The Success of the Visiting Scholars in Pediatric Anesthesia Program (ViSiPAP) as a Hybrid Model for Perioperative Education. Paediatric anaesthesia 2025. link 52 Sawada N, Kawada JI, Kito S, Takeo T, Narita H, Fukushima M et al.. Application of simple preparation for pediatric magnetic resonance imaging: a multicenter study in Japan. Pediatric radiology 2025. link 53 Bardol M, Sheng Y, Baarslag M, Ceci A, Dörje F, Ilmoja ML et al.. Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care. Paediatric anaesthesia 2025. link 54 Kracht A, Billion M, Feldhaus K, Ali M. Is a Switch to Nurse Administered Nitrous Oxide Sedation Feasible and Effective? A Quality Improvement Project. South Dakota medicine : the journal of the South Dakota State Medical Association 2025. link 55 Annan BNY, Owusu Darkwa E, Anno A, Vanderpuye NM, Baffour-Awuah L, Obeng Adjei GI et al.. Appropriateness and safety of using the intranasal route for sedation during pediatric computed tomography: A randomized controlled trial at Korle-Bu teaching hospital. The Journal of international medical research 2025. link 56 Merkel L, Drouillard M, Wiggins S, Struwe L, Samson K. Identification of risk factors for emergence delirium in children undergoing magnetic resonance imaging. Journal of pediatric nursing 2025. link 57 Oluş F, Babun H. Sedation applications in pedodontics procedures: which one should we choose?: a retrospective analysis. BMC oral health 2025. link 58 Li YS, Lin SP, Chang WK, Chien-Kun T. Safety of a higher thiamylal induction dose in pediatric sedation for magnetic resonance imaging scans. European journal of medical research 2025. link 59 Newton L, Sulman C. Implementation of a phased onboarding program for novice advanced practice providers. International journal of pediatric otorhinolaryngology 2025. link 60 Uyar E, Gürsoy G, Bozkaya İO, Koçkuzu E, Emeksiz S, Bilir ÖA et al.. Critical Care Outcomes in Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Pediatric Intensive Care Unit Experience. Pediatric transplantation 2025. link 61 Gonzalez Jiménez D, Rodríguez Delgado J, Campoy C, Galera Martínez R, Gil-Campos M, Redecillas Ferreiro S et al.. Vitamin D supplementation in the healthy pediatric population. Anales de pediatria 2025. link 62 Jain C, Balachandran U, Valdivia LM, Koehne NH, Yendluri A, Namiri NK et al.. Decrease in pediatric farm-related injuries presenting to United States emergency departments: A national study from 2014-2023. Injury 2025. link 63 Chong S, Sun L, Mu G, Hua M, Xiang Q, Cui Y. Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study. Paediatric drugs 2025. link 64 Laraja K, Mansfield L, Lombardi K, Ford S, Simoncini L, Simas TM. A Novel Approach to Mentorship in Pediatric Cardiology: A Group for Women. Pediatric cardiology 2025. link 65 Roggero P, Grima AM, Crespo-Escobar P, Tapsas D, Yahav J. Conflict between parents, physicians, and healthcare professionals in medical decision-making: How to address it-A systematic review from the ESPGHAN Ethics Committee. Journal of pediatric gastroenterology and nutrition 2024. link 66 Ba H, Zhang L, Yi Z. Enhancing clinical skills in pediatric trainees: a comparative study of ChatGPT-assisted and traditional teaching methods. BMC medical education 2024. link 67 Silverstein A, Easton V, Barrows C, Sawyer K, Coughlin R, Mali N et al.. Dignity in the Pediatric Population: A Systematic Review. Journal of pain and symptom management 2024. link 68 Gudipudi R, Jungbauer WN, Brennan E, Pecha PP. Parent and provider satisfaction of telehealth in pediatric surgical subspecialty care: A systematic review. Journal of telemedicine and telecare 2024. link 69 Elahmedi M, Sawhney R, Guadagno E, Botelho F, Poenaru D. The State of Artificial Intelligence in Pediatric Surgery: A Systematic Review. Journal of pediatric surgery 2024. link 70 Weinstein R, Naber CE, Brumme K. Revisiting dexamethasone use in the pediatric emergency department. Current opinion in pediatrics 2024. link 71 Woo P, Petty RE. Eric Bywaters and Barbara Ansell: Founders of Modern Pediatric Rheumatology. Rheumatic diseases clinics of North America 2024. link 72 Bideau M. [The challenges of pediatric emergencies in the office]. Revue medicale suisse 2024. link 73 Schmucker M, Reiswich A, Haag M. A Pipeline for Real-Time Synchronization of Relevant Data in Pediatric Emergencies. Studies in health technology and informatics 2024. link 74 Ezeoke OM, Williams J, Ogueri V, Hills BK. The Heart of the Matter: A Path to Building Diversity in Pediatric Cardiology. Pediatric cardiology 2024. link 75 Gritti MN, AlTurki H, Farid P, Morgan CT. Progression of an Artificial Intelligence Chatbot (ChatGPT) for Pediatric Cardiology Educational Knowledge Assessment. Pediatric cardiology 2024. link 76 Kim ME, Franklin W, Dubin AM, Kim JJ, Sanatani S, Kumar RK et al.. What Makes an Effective Chief of Pediatric Cardiology: Insights From Chiefs of North American Pediatric Programs. Journal of the American Heart Association 2024. link 77 Jump C, Shaikhkhalil A, Smith A, Oliveira SB, Chugh A, Carey A et al.. Implementation and participation of an online nutrition curriculum for pediatric gastroenterology fellows. Journal of pediatric gastroenterology and nutrition 2024. link 78 Fraher E, Knapton A, McCartha E, Leslie LK. Forecasting the Future Supply of Pediatric Subspecialists in the United States: 2020-2040. Pediatrics 2024. link 79 Bellini T, Orfanos I. Ten new paediatric emergency medicine commandments. Acta paediatrica (Oslo, Norway : 1992) 2024. link 80 Budnik E, Klekowski N, Carney M, Tucker R. The Development of a Combined Pediatric Emergency Medicine and Point-of-Care Ultrasound Curriculum. Pediatric emergency care 2024. link 81 Hrdy M, Faig W, Ren D, Lee B, Tay KY, Guttadauria B et al.. A Comparison of Telesimulation Using the Virtual Resus Room and In Situ Simulation in Pediatric Emergency Medicine. Pediatric emergency care 2024. link 82 Zamor RL, Liberman DB, Hall JE, Rees CA, Hartford EA, Chaudhari PP et al.. Collecting Sociodemographic Data in Pediatric Emergency Research: A Working Group Consensus. Pediatrics 2024. link 83 Toto RL, Fischer J, Mamtani M, Scott KR, Bauman B, Delgado EM. Identified Needs in Pediatric Education for Emergency Medicine Physicians: A Qualitative Analysis. Pediatric emergency care 2024. link 84 Bechtel K, Langhan ML, Levine D, Hanson J. Pediatric Emergency Medicine and Mentoring: What Women Want. Pediatric emergency care 2024. link 85 Lee MS, Sweetnam-Holmes D, Soffer GP, Harel-Sterling M. Updates on the clinical integration of point-of-care ultrasound in pediatric emergency medicine. Current opinion in pediatrics 2024. link 86 Wolfgang M, Labudde EJ, Ruff K, Geis G, Frey M, Boyd S et al.. Structured Callouts, the Shared Mental Model, and Teamwork: A Video-Based Study in a Pediatric Emergency Department. Pediatric emergency care 2024. link 87 Skotnicki BS, Wilson PM, Kazmerski TM, Manole MD, Kinnane JM, Lunoe MM. Gender Differences in Work-Life Integration, Career Satisfaction, and Burnout in Pediatric Emergency Medicine Physicians: A Cross-Sectional Analysis. Pediatric emergency care 2024. link 88 Arand CR, Noble J, Haber BD, Favot MJ, Ehrman RR. Point-of-Care-Ultrasound Quality Assurance Data From Fellow-Performed Exams in a Pediatric Emergency Department: A Descriptive Study. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2024. link 89 Chen WF, Chan YK, Chang WH, Hsieh MY. Pediatric Life Support in Prehospital Emergency Medicine: An Empirical Investigation in the Context of Taiwan's Critical Shortage of Pediatric Emergency Specialists. Discovery medicine 2024. link 90 Easter JS, Rose E. Advances in pediatric emergency from 2023. The American journal of emergency medicine 2024. link 91 Assaf RR, Assaf RD, Doucet HB, Graff D. Social Care Education and Training Among US Pediatric Emergency Medicine Fellowship Programs. Pediatric emergency care 2024. link 92 Vrablik L, Wing R. Pediatric Polytrauma Fire Victim Simulation. MedEdPORTAL : the journal of teaching and learning resources 2024. link 93 Yee J, Auerbach MA, Wong KU, Kaur S, Burns RA. Dissemination, Utilization, and Satisfaction With Emergency Medicine Resident Simulation Curriculum for Pediatrics (EM ReSCu Peds) by North American Residency Programs. Pediatric emergency care 2024. link 94 Gutiérrez CE, Lim R, Chu S. Current progress in international pediatric emergency medicine. Current opinion in pediatrics 2024. link 95 Ruscica A, Dessie A, Jamal N, Roskind C. Use of a Rubric for Pediatric Emergency Medicine Fellowship Application Review. Pediatric emergency care 2024. link 96 Moake MM, Klekowski N, Kusulas MP, Kharasch SJ, Teng D, Constantine E. The Current State of Advanced Pediatric Emergency Medicine Point-of-Care Ultrasound (POCUS) Training: Exploring Recent POCUS Fellowship Application Trends and Alternate Training Models. Pediatric emergency care 2024. link 97 Kothari K, Shah MI, Genovesi AL, Gausche-Hill M, Owusu-Ansah S, Hewes H et al.. Development of the National Prehospital Pediatric Readiness Project assessment. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2024. link 98 Mitzman J, Reynolds M, Panchal A, Yee J. A Pilot Study of a Simulation-Based Mastery Learning Procedural Curriculum for Pediatric Emergency Medicine Fellows. Pediatric emergency care 2024. link 99 Ramgopal S, Varma S, Gorski JK, Kester KM, Shieh A, Suresh S. Evaluation of a Large Language Model on the American Academy of Pediatrics' PREP Emergency Medicine Question Bank. Pediatric emergency care 2024. link 100 Baghdassarian A, Bailey JA, Caglar D, Eckerle M, Fang A, McVety K et al.. Virtual Interviews and the Pediatric Emergency Medicine Match Geography: A National Survey. The western journal of emergency medicine 2024. link