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Autoimmune male infertility

Last edited: 4/10/2026

Overview

Autoimmune male infertility is a condition where the immune system produces antibodies that target sperm, impairing fertility 12. This can affect sperm motility, binding, and penetration of the egg 1.

Diagnosis

  • Evaluation includes a thorough history and physical examination 1.
  • Diagnostic testing may be indicated based on initial assessment 1.
  • Specific diagnostic criteria and grading are not detailed in the provided abstracts.
  • Management

  • Management strategies include medical therapies, surgical techniques, and assisted reproductive technologies such as intrauterine insemination (IUI), in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI) 2.
  • Specific drug classes or doses for medical therapies are not mentioned in the abstracts.
  • Key Recommendations

  • The evaluation of the infertile male should include an appropriate history and physical exam, as well as diagnostic testing where indicated 1. (Evidence: Moderate)
  • Management of male infertility may involve medical therapies, surgical techniques, and assisted reproductive technologies like IUI, IVF, and ICSI 2. (Evidence: Moderate)
  • The detection of male infertility increases the risk of subsequent development of health problems for men 1. (Evidence: Moderate)
  • References

    1 Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ et al.. Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline Part I. The Journal of urology 2021. link 2 Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ et al.. Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline PART II. The Journal of urology 2021. link

    Original source

    1. [1]
      Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline Part I.Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ et al. The Journal of urology (2021)
    2. [2]
      Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline PART II.Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ et al. The Journal of urology (2021)

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