Overview
Mitral annular disjunction (MAD) is a condition characterized by a separation between the mitral annulus and the left ventricular myocardium 1. It frequently co-occurs with mitral valve prolapse (MVP) 1. MAD is associated with an increased risk of complex ventricular arrhythmias (VA) and sudden cardiac death (SCD) 1.Diagnosis
Complex ventricular arrhythmias are significantly higher in patients with MAD compared to those without MAD 1.
The composite outcome of complex VA and SCD is also higher in patients with MAD 1.Management
Management strategies for ventricular arrhythmias in the context of MAD are not detailed in the provided abstracts.Key Recommendations
The presence of mitral annular disjunction (MAD) is significantly associated with the development of complex ventricular arrhythmias 1. (Evidence: Moderate)
Mitral annular disjunction (MAD) is significantly associated with an increased risk of the composite outcome of complex ventricular arrhythmias and sudden cardiac death 1. (Evidence: Moderate)References
1 Gonçalves LS, Tanus LMA, Queiroz LA, Dall'Acqua JC, Campello CA, Nogueira PC. Complex Ventricular Arrhythmias in Patients with Mitral Annular Disjunction: A Systematic Review and Meta-Analysis. Echocardiography (Mount Kisco, N.Y.) 2025. link