Overview
Drug-induced insulin coma in nondiabetic patients occurs when certain medications interfere with glucose metabolism, leading to severe hypoglycemia and altered mental status, resembling an insulin coma 1.Diagnosis
Clinical presentation includes profound hypoglycemia, altered mental status, and often seizures 1.
Laboratory tests should confirm low blood glucose levels and evaluate for ketosis 1.
Electrolyte imbalances and liver function tests may also be relevant 1.Management
Immediate treatment involves rapid correction of hypoglycemia with intravenous dextrose 1.
Supportive care includes airway management and monitoring for complications 1.
Monitoring for drug-specific toxicities and adjusting treatment accordingly is essential 1.Special Populations
No specific data provided regarding pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1.Key Recommendations
Rapidly administer intravenous dextrose to correct hypoglycemia (Evidence: Expert opinion) 1.
Closely monitor electrolyte levels and liver function during treatment (Evidence: Expert opinion) 1.
Consider drug-specific toxicities and adjust management strategies accordingly (Evidence: Expert opinion) 1.References
1 Zhu Z, Gao P, Hu Y, Wang J, Wang H, Yang J et al.. PEGylated versus non-PEGylated drugs: A cross-sectional analysis of adverse events in the FDA Adverse Event Reporting System (FAERS) Database
. International journal of clinical pharmacology and therapeutics 2020. link