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Emergency Medicine155 papers

Gender dysphoria in adolescence and adulthood

Last edited: 4/15/2026

Overview

Gender dysphoria involves significant distress related to a mismatch between a person's sex assigned at birth and their experienced gender identity, affecting individuals across adolescence and adulthood 1.

Diagnosis

  • Presence of persistent discomfort with one's assigned gender
  • Strong identification with another gender
  • Desire for changing primary and/or secondary sex characteristics 1
  • No specific recommended diagnostic tests; clinical assessment is key 1
  • Management

  • Psychotherapeutic support, including gender-affirming psychotherapy 1
  • Hormonal therapy:
  • - For adolescents: GnRH analogues followed by gender-affirming hormones (e.g., testosterone for transgender males, estrogen for transgender females) 1 - For adults: Initiation of gender-affirming hormones based on individual assessment 1
  • Surgical interventions considered for those who desire and are appropriate candidates 1
  • Special Populations

  • Pediatrics: Early intervention with multidisciplinary support crucial; hormonal therapy typically initiated under strict medical supervision post-pubertal suppression 1
  • Comorbidities: Addressing mental health conditions like depression and anxiety concurrently is essential 1
  • Key Recommendations

  • Incorporate education on sexual and gender minorities into postgraduate medical training to improve competency and reduce health disparities (Evidence: Expert opinion) 1
  • Provide culturally competent care through comprehensive training, recognizing that positive attitudes alone are insufficient without adequate knowledge (Evidence: Expert opinion) 1
  • Offer multidisciplinary support including psychological counseling and gender-affirming medical interventions tailored to individual needs (Evidence: Expert opinion) 1
  • References

    1 Burcheri A, Coutin A, Bigham BL, Kruse MI, Lien K, Lim R et al.. Exploring a case for education about sexual and gender minorities in postgraduate emergency medicine training: forming recommendations for change. Postgraduate medicine 2023. link

    Original source

    1. [1]

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