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Psychostimulant dependence in remission

Last edited: 4/15/2026

Overview

Psychostimulant dependence in remission refers to the state where an individual has ceased active substance use but remains at risk for relapse and may experience withdrawal symptoms or psychological cravings 1.

Diagnosis

  • Clinical history of chronic psychostimulant use
  • Absence of active substance use confirmed through toxicology screens 1
  • Presence of withdrawal symptoms or heightened sensitivity to stress 1
  • Psychological assessment for cravings and mood disturbances 1
  • Management

  • Cognitive-behavioral therapy (CBT) as first-line psychological intervention 1
  • Adjunctive pharmacotherapy with selective serotonin reuptake inhibitors (SSRIs) for co-occurring depression or anxiety 1
  • Monitoring and support groups to reduce relapse risk 1
  • Special Populations

  • No specific evidence provided for pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1
  • Key Recommendations

  • Utilize cognitive-behavioral therapy for managing psychostimulant dependence in remission (Evidence: Moderate) 1
  • Consider selective serotonin reuptake inhibitors for co-morbid mood disorders (Evidence: Moderate) 1
  • Implement structured support programs to enhance long-term recovery outcomes (Evidence: Expert opinion) 1
  • References

    1 Amendt HL, Siedenburg JS, Steffensen N, Söbbeler FJ, Schütter A, Tünsmeyer J et al.. Transcranial magnetic stimulation with acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide in healthy Beagle dogs. Veterinary journal (London, England : 1997) 2016. link

    Original source

    1. [1]
      Transcranial magnetic stimulation with acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide in healthy Beagle dogs.Amendt HL, Siedenburg JS, Steffensen N, Söbbeler FJ, Schütter A, Tünsmeyer J et al. Veterinary journal (London, England : 1997) (2016)

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