Overview
Isolated agenesis of the cerebellar vermis refers to a congenital condition characterized by the absence or underdevelopment of the cerebellar vermis, a midline structure of the cerebellum. Cerebellar vermis alterations, including volumetric changes, have been documented in psychotic disorders 1.Diagnosis
Association between cerebellar vermis hypoplasia and psychotic disorders, particularly schizophrenia, has been suggested 1.
Studies on schizophrenia and subjects at psychotic risk suggest gray matter volume reduction and increased white matter volumes in the cerebellar vermis compared to controls 1.
Findings in bipolar disorder patients are more heterogeneous, with evidence of reduced, unchanged, or increased cerebellar vermis volume 1.Management
No management strategies for isolated agenesis of the cerebellar vermis are discussed in the provided abstracts.Special Populations
No information on special populations is available in the provided abstracts.Key Recommendations
Consider a possible correlation between cerebellar vermis hypoplasia and psychotic disorders, especially schizophrenia 1. (Evidence: Moderate)
Recognize that findings in bipolar disorder patients regarding cerebellar vermis volume are heterogeneous 1. (Evidence: Moderate)
Hypothesize psychotic disorders as neurodevelopmental disorders, potentially supported by cerebellar vermis alterations 1. (Evidence: Weak)References
1 Dusi N, Esposito CM, Delvecchio G, Prunas C, Brambilla P. Case report and systematic review of cerebellar vermis alterations in psychosis. International clinical psychopharmacology 2024. link