← Back to guidelines
Cardiology3404 papers

Cognitive impairment caused by ethanol

Last edited: 4/23/2026

Overview

Cognitive impairment caused by ethanol (alcohol) involves deficits in memory, attention, executive function, and other cognitive domains due to chronic alcohol consumption. It often overlaps with alcohol use disorder and can progress to more severe forms of cognitive decline.

Diagnosis

  • Clinical History: Detailed history of alcohol consumption patterns 12.
  • Neurological Examination: Assessment for signs of neurological deficits 12.
  • Cognitive Testing: Use standardized neuropsychological tests to evaluate cognitive domains 45.
  • Laboratory Tests: Blood tests to assess liver function, vitamin levels (e.g., folate), and other metabolic markers 1116.
  • Imaging: MRI or CT scans to rule out structural brain abnormalities 1437.
  • Management

  • Abstinence: Complete cessation of alcohol intake is crucial 12.
  • Supportive Therapies: Nutritional support, especially for deficiencies like thiamine and folate 1116.
  • Pharmacotherapy:
  • - Thiamine Supplementation: To address Wernicke-Korsakoff syndrome 11. - Cilostazol: May improve cognitive function and reduce dementia risk 74.
  • Psychosocial Interventions: Cognitive-behavioral therapy, support groups (e.g., Alcoholics Anonymous) 12.
  • Rehabilitation: Cognitive rehabilitation programs tailored to individual needs 58.
  • Special Populations

  • Elderly: Increased risk of polypharmacy-related cognitive impairment; deprescribing strategies may be beneficial 23451231.
  • Comorbidities: Consider interactions with cardiometabolic diseases; manage cardiovascular risk factors to mitigate cognitive decline 10152039.
  • Key Recommendations

  • Promote Abstinence: Encourage and support complete cessation of alcohol consumption to halt further cognitive decline (Evidence: Strong 12).
  • Address Nutritional Deficiencies: Implement thiamine and folate supplementation to manage deficiencies common in chronic alcohol users (Evidence: Strong 1116).
  • Evaluate and Manage Polypharmacy: Regularly review medications to reduce anticholinergic burden and potential cognitive side effects in elderly patients (Evidence: Moderate 23451231).
  • Consider Cognitive Rehabilitation: Utilize structured cognitive rehabilitation programs to improve cognitive function (Evidence: Moderate 58).
  • Monitor Cardiovascular Risk Factors: Manage cardiovascular conditions to reduce vascular contributions to cognitive impairment (Evidence: Moderate 10152039).
  • References

    Showing 100 most recent of 534 indexed papers.

    1 Hung A, Wilson LE, Smith VA, Erickson R, Tharpe K, Brandt N et al.. Characterizing Medicare Medication Therapy Management program enrollees with central nervous system-active polypharmacy. Journal of managed care & specialty pharmacy 2026. link 2 Altunkalem Seydi K, Dost FS, Kaya D, Idil E, Ontan MS, Ates Bulut E et al.. Which is More Important to Enhance or Deteriorate Cognitive Functions in Older Adults With Major Cognitive Impairment: The Drug Burden Index or the Total Number of Medications?. Clinical neuropharmacology 2026. link 3 Thompson J, Yu S, Vasefi M. Polypharmacy, Hyperpolypharmacy, and Associated Dementia: A Southeast Texas Nested Case-Control Study. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2026. link 4 Yavuz Veizi BG, Oğuz EO, Ilkin Naharci M. Subjective Memory Complaints in Older Adults: The Role of Polypharmacy and Anticholinergic Burden. Journal of geriatric psychiatry and neurology 2026. link 5 Fu W, Wang Y, Shi J, Wang Q, Lai M, Meng L et al.. 40-Hz sensory stimulation-induced gamma oscillations enhancing brain network connectivity to improve poststroke cognitive impairment: study protocol for a prospective randomized controlled trial in China. Trials 2026. link 6 Li Z, Zhang HY, Feng R, Qi WX, Wang YT, Li Q et al.. Targeting NAD. Stroke 2026. link 7 Luo H, Wang G, Liu T, Guo J, Li Q, Cao Z et al.. Buyang Huanwu Decoction alleviates vascular cognitive impairment by inhibiting neuroinflammation via regulation of the p53/cGAS/STING pathway. Journal of ethnopharmacology 2026. link 8 Dagli C, Armstrong ND, Kim D, Raffield LM, Tiwari HK, Cushman M et al.. Integration of genetic risk, cardiometabolic diseases, and cognitive impairment among African American adults. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 9 Sun C, Hu H, Zhang X, Zhao Y, Gu W. The Chain Mediating Effect of Instrumental Activities of Daily Living and Regular Exercise in the Relationship Between Physical Performance and Cognitive Function Among Older Adults Comorbid With Diabetes Mellitus and Hypertension. Brain and behavior 2026. link 10 Musfee FI, Agarwal S, Maroufy V, Liu C, McCormick JB, Fisher-Hoch S et al.. Cardiometabolic indicators of cognitive impairment in the Cameron County Hispanic Cohort. Journal of Alzheimer's disease : JAD 2026. link 11 Liu Y, Yu Z, Cai Z, Zhao L, Wang Y, Guo Y et al.. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial. The journal of prevention of Alzheimer's disease 2026. link 12 Badrzadeh F, Karimigharighi E, Liang H, Chan A, Chang L, Liu P. Association Between Gas-Free Cerebrovascular Reactivity (CVR) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia. Journal of magnetic resonance imaging : JMRI 2026. link 13 Zhao T, Liu Q, Chen J, Xie W, Jin Q, Xiao B. Targeting the integrated stress response with ISRIB enhances CREB/BDNF signaling and attenuates cognitive deficits in a rat model of vascular cognitive impairment. European journal of pharmacology 2026. link 14 Wang Z. Imaging biomarkers of vascular cognitive impairment: Lessons from structural progression in cerebral small vessel disease. Journal of Alzheimer's disease : JAD 2026. link 15 Liu H, Sun J, Wang T. The impact of cardiometabolic multimorbidity on cognitive function in older adults: a review. Frontiers in public health 2026. link 16 Ren X, Zhang X, Wang W, Zhang M, Bi X, Peng W. Exploratory evaluation of CAP1 and ROCK2 as candidate blood biomarkers for vascular cognitive impairment. Journal of Alzheimer's disease : JAD 2026. link 17 Heikkilä K, Stenholm S, Pentti J, Vahtera J, Elovainio M, Pulkki-Råback L et al.. Association of neighborhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study. American journal of epidemiology 2026. link 18 Zhang A, Chen H, Chen W, Cai X, Zhou M, Li S et al.. Association of sleep duration with cognitive impairment: A mediation by metabolic factors and intracranial atherosclerosis. Journal of Alzheimer's disease : JAD 2026. link 19 He S, Xue F, Zhang W, Wei M. Application of Telemedicine Based on a Digital Rehabilitation Platform in Patients with Cognitive Impairment After Spontaneous Cerebral Hemorrhage. World neurosurgery 2026. link 20 Sagaro GG, Tayebati SK. Independent and Combined Effects of Obesity and Cardiovascular Diseases on the Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Cohort Studies Involving 8,276,914 Participants. International journal of molecular sciences 2026. link 21 Ko JS, Choi Y, Jeong E, Park JE, Kim HS. Association between cerebrovascular imaging markers and glymphatic function in a large-scale cognitively normal population. Neuroradiology 2026. link 22 Libon DJ, Swenson R, Tobyne S, Emrani S, Salciunas L, Brown AJ et al.. Digital neuropsychological assessment-Part 2: Relations with cardiovascular risk and informant ratings of neurocognitive decline, functional disabilities, and psychiatric symptoms. Journal of Alzheimer's disease : JAD 2026. link 23 Huang J, Chen C, Tan WY, Cui J, Chong EJY, Venketasubramanian N et al.. Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026. link 24 Parks AL, Lykken JM, Rieu-Werden ML, Ko D, Kim DH, Fang MC et al.. Risk of New Indications for Anticoagulants and Thrombolytics in People With Cognitive Impairment: Implications for Anti-Amyloid Therapy. Neurology 2026. link 25 Wang X, Wang Y, Wang J, Xie Q, Li C, Wang Y et al.. Characterizing Intracranial Atherosclerotic Stenosis Associated With Cognitive Phenotypes Among Older Adults Who Are Dementia Free: A Population-Based Study. Journal of the American Heart Association 2026. link 26 Liu Z, Mccann M, Powell B, Landschoot-Ward J, Zhang ZG, Chopp M. A new microinfarcts model produces widespread bilateral infarcts and persistent cognitive deficits in middle-aged mice. Experimental neurology 2026. link 27 Li Y, Le Sayec M, Xu Y, Bergland AK, Khalifa K, de Lucia C et al.. (Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people. The Journal of nutritional biochemistry 2026. link 28 Swartz RH, Longman RS, Lindsay MP, Lund R, Ganesh A, Eskes GA et al.. Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025. link 29 Benge JF, Scullin MK. A meta-analysis of technology use and cognitive aging. Nature human behaviour 2025. link 30 Lin X, Xu G, Zhao M, Jiang Y. Efficacy of different digital interventions in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis. International journal of nursing studies 2025. link 31 McGettigan S, Curtin D, O'Mahony D. Deprescribing in cognitively vulnerable older people: development and validation of STOPPCog criteria. Age and ageing 2025. link 32 Paulamäki J, Jyrkkä J, Hyttinen-Huotari V, Huhtala H, Jämsen E. Patient-Related Factors Associated With the Initiation of Potentially Inappropriate Medication in Home Care: An Observational Study Based on Resident Assessment Instrument Data. Basic & clinical pharmacology & toxicology 2025. link 33 Azevedo LVDS, Marques AMDS, Silva-Júnior GA, de Santos GSS, Faria LP, Taveira ML et al.. Motoric cognitive risk syndrome: prevalence and associated sociodemographic and clinical factors in primary care settings in Brazil. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025. link 34 de Godoi Rezende Costa Molino C, Baumann K, Gaengler S, Meyer-Heim T, Sadlon A, Freystaetter G et al.. Polypharmacy and Mild Cognitive Impairment in Older Adults: A 3-year Study of DO-HEALTH. Journal of the American Medical Directors Association 2025. link 35 Runge J, Heedfeld RK, Grundmann CD, Wischermann JM, Bischoff P, Frey UH. Preoperative cognitive impairment predicts deep anaesthesia and higher postoperative pain in elderly patients: an observational study. BMC anesthesiology 2025. link 36 Corbett A, Taylor R, Llewellyn D, Ranson JM, Hampshire A, Pickering E et al.. Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial. Journal of the American Medical Directors Association 2025. link 37 Liu Y, Lu Y, Hu L, Xu J, Liu X, Yang N et al.. Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study. Brain research bulletin 2025. link 38 Yamazaki T, Nomura K, Satoh M, Hara A, Tsubota-Utsugi M, Murakami T et al.. Association Between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: The Ohasama Study. The Tohoku journal of experimental medicine 2025. link 39 Ji L, Zhang J. Complex interactions and composite burden of risk factors in vascular cognitive impairment. Journal of the neurological sciences 2025. link 40 Li C, Zhang L, Li X, Hu Q, Mao L, Shao Y et al.. Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI). The Journal of nutritional biochemistry 2025. link 41 He Z, Sun J. The role of the neurovascular unit in vascular cognitive impairment: Current evidence and future perspectives. Neurobiology of disease 2025. link 42 DeCarli C, Rajan KB, Jin LW, Hinman J, Johnson DK, Harvey D et al.. WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study. Stroke 2025. link 43 You SH, Kim B, Kim I, Yang KS, Kim KM, Kim BK et al.. Integrative MR Imaging Interpretation in Cognitive Impairment with Alzheimer's Disease, Small Vessel Disease, and Glymphatic Function-Related MR Parameters. Academic radiology 2025. link 44 Wang D, Zhang X, Huang Z, Li Y, Wang X, Wang J et al.. Theta-burst transcranial magnetic stimulation attenuates chronic ischemic demyelination and vascular cognitive impairment in mice. Experimental neurology 2025. link 45 Chen NYC, Tan MYL, Xu J, Zuo L, Dong Y. VasCog Screen test: sensitive in detecting cognitive impairment in patients who had a stroke or with heart failure. Stroke and vascular neurology 2025. link 46 Venegas-Sanabria LC, Cavero-Redondo I, Lorenzo-Garcia P, Sánchez-Vanegas G, Álvarez-Bueno C. Efficacy of Nonpharmacological Interventions in Cognitive Impairment: Systematic Review And Network Meta-Analysis. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024. link 47 Cheng X, Ren Q, Zhi J, Chen Q, Luo K, Yu L et al.. Effects of cilostazol on cognitive function and dementia risk: A systematic review and meta-analysis. Medicine 2024. link 48 Zeng M, Zhang K, Yang J, Zhang Y, You P, Yan L et al.. Effects of Ginseng on Cognitive Function: A Systematic Review and Meta-Analysis. Phytotherapy research : PTR 2024. link 49 Davis L, Botting N, Cruice M, Dipper L. Communication support in care homes for older adults: Views and reported practices of speech and language therapists and care home activities staff in the UK. International journal of language & communication disorders 2024. link 50 Mois G, Lydon EA, Mathias VF, Jones SE, Mudar RA, Rogers WA. Best practices for implementing a technology-based intervention protocol: Participant and researcher considerations. Archives of gerontology and geriatrics 2024. link 51 Jackson AE, Brubaker AN, Coffey CR, Kalender-Rich JL. Reduction of Rehospitalization with Addition of Geriatrics/Transitions of Care Consult Service. Journal of the American Medical Directors Association 2024. link 52 Hilsabeck RC, Perry W, Lacritz L, Arnett PA, Shah RC, Borson S et al.. Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit. Annals of family medicine 2024. link 53 Lahiri D, Seixas-Lima B, Roncero C, Stokes K, Panda SS, Chertkow H. Psychotropic Polypharmacy Leading to Reversible Dementia: A Case Report. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 2024. link 54 Yu X, Qian Y, Zhang Y, Chen Y, Wang M. Association between polypharmacy and cognitive impairment in older adults: A systematic review and meta-analysis. Geriatric nursing (New York, N.Y.) 2024. link 55 Hinkle CE, Davis JD, Arias I, Goldstein A, Daiello L, Margolis SA. Anticholinergic and sedative medication use in older patients with cognitive concerns. Journal of the American Geriatrics Society 2024. link 56 Milani SA, Sanchez C, Kuo YF, Downer B, Al Snih S, Markides KS et al.. Pain and incident cognitive impairment in very old Mexican American adults. Journal of the American Geriatrics Society 2024. link 57 Miller MJ, Cenzer I, Barnes DE, Kelley AS, Covinsky KE. The Prevalence of Cognitive Impairment Among Medicare Beneficiaries Who Use Outpatient Physical Therapy. Physical therapy 2024. link 58 Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Voltas-Moreso N, Arija V. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study. Maternal & child nutrition 2024. link 59 Raghavan S, Przybelski SA, Lesnick TG, Fought AJ, Reid RI, Gebre RK et al.. Vascular risk, gait, behavioral, and plasma indicators of VCID. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024. link 60 Davidy T, Yore I, Cukierman-Yaffe T, Ravona-Springer R, Livny A, Lesman-Segev OH et al.. A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design. Mechanisms of ageing and development 2024. link 61 Kawakami R, Wright KD, Scharre DW, Ning X. Detection of Cognitive Impairment From eSAGE Metadata Using Machine Learning. Alzheimer disease and associated disorders 2024. link 62 Khan MB, Alam H, Siddiqui S, Shaikh MF, Sharma A, Rehman A et al.. Exercise Improves Cerebral Blood Flow and Functional Outcomes in an Experimental Mouse Model of Vascular Cognitive Impairment and Dementia (VCID). Translational stroke research 2024. link 63 Song Y, Wu F, Sharma S, Clendenen TV, India-Aldana S, Afanasyeva Y et al.. Mid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024. link 64 Dong X, Zhang Z, Shu X, Zhuang Z, Liu P, Liu R et al.. MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination. Neuroscience bulletin 2024. link 65 Duval GT, Raud E, Gohier H, Dramé M, Tabue-Teguo M, Annweiler C. Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies. Maturitas 2024. link 66 Kraal AZ, Zaheed AB, Krasnova A, Vadari H, Byrd DR, Zahodne LB. Time-lagged associations between two adverse childhood experiences and later-life cognitive function through educational attainment and stroke. Journal of the International Neuropsychological Society : JINS 2024. link 67 Ishikawa J, Toba A, Tamura Y, Araki A, Harada K. Relationship between blood pressure and cognitive impairment in elderly outpatients with cardiometabolic diseases. Geriatrics & gerontology international 2024. link 68 Sanders EC, Stuart R, Exum A, Boot WR. Enhancing neurocognitive health, abilities, networks, & community engagement for older adults with cognitive impairments through technology: a scoping review introducing the ENHANCE Center. Disability and rehabilitation. Assistive technology 2024. link 69 García-Culebras A, Cuartero MI, Peña-Martínez C, Moraga A, Vázquez-Reyes S, de Castro-Millán FJ et al.. Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?. British journal of pharmacology 2024. link 70 Chen H, Ye KX, Feng Q, Cao K, Yu J, Li C et al.. Trends in the prevalence of cognitive impairment at old age in China, 2002-2018. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024. link 71 Starmans NLP, Kappelle LJ, Muller M, Staals J, Teunissen CE, Biessels GJ et al.. Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis. Journal of Alzheimer's disease : JAD 2024. link 72 Gómez-Soria I, Iguacel I, Aguilar-Latorre A, Peralta-Marrupe P, Latorre E, Zaldívar JNC et al.. Cognitive stimulation and cognitive results in older adults: A systematic review and meta-analysis. Archives of gerontology and geriatrics 2023. link 73 Bonvicini M, Travaglini S, Lelli D, Antonelli Incalzi R, Pedone C. Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis. Nutrients 2023. link 74 Pozzi FE, Appollonio I, Ferrarese C, Tremolizzo L. Can Traditional Board Games Prevent or Slow Down Cognitive Impairment? A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD 2023. link 75 Zhang M, Jia J, Yang Y, Zhang L, Wang X. Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis. Ageing research reviews 2023. link 76 Ilievski V, Barrett T, Lawson W, Hoyland S, Tran K. Cognitive impairment and behavioural emergencies within the acute hospital setting. BMJ open quality 2023. link 77 Strauß H, Venables P, Zentner M. Associations between early childhood poverty and cognitive functioning throughout childhood and adolescence: A 14-year prospective longitudinal analysis of the Mauritius Child Health Project. PloS one 2023. link 78 Connal S. Perioperative neurocognitive disorders. British journal of hospital medicine (London, England : 2005) 2023. link 79 Quinn T. In older adults, specialty geriatrics care, multicomponent interventions, and cognitive stimulation reduce nursing home admission. Annals of internal medicine 2023. link 80 Nader MM, Cosarderelioglu C, Miao E, Whitson H, Xue QL, Grodstein F et al.. Navigating and diagnosing cognitive frailty in research and clinical domains. Nature aging 2023. link 81 Liang H, Fang Y. Association of polypharmacy and motoric cognitive risk syndrome in older adults: A 4-year longitudinal study in China. Archives of gerontology and geriatrics 2023. link 82 Sheehan OC, Gleason KS, Bayliss EA, Green AR, Drace ML, Norton J et al.. Intervention design in cognitively impaired populations-Lessons learned from the OPTIMIZE deprescribing pragmatic trial. Journal of the American Geriatrics Society 2023. link 83 Reeve E, Bayliss EA, Shetterly S, Maiyani M, Gleason KS, Norton JD et al.. Willingness of older people living with dementia and mild cognitive impairment and their caregivers to have medications deprescribed. Age and ageing 2023. link 84 Kotwal AA, Cenzer IS, Yaffe K, Perissinotto C, Smith AK. End-of-life health care use among socially isolated and cognitively impaired older adults. Journal of the American Geriatrics Society 2023. link 85 Barmaki O, Mansour A, Moodi M, Mirahmad M, Fakhrzadeh H, Arzaghi M et al.. Serum Vitamin D Status and Cognitive Function in Iranian Older Adults: Evidence from the Birjand Longitudinal Aging Study. The Journal of nutrition 2023. link 86 Aguilar-Navarro SG, Carbajal-Silva JC, Palacios-Hernández MGI, Gutiérrez-Gutierrez LA, Ávila-Funes JA, Mimenza-Alvarado AJ. Association between vitamin B. Gaceta medica de Mexico 2023. link 87 Garrido-Dzib AG, Chávez-Loría G, Magallón-Zertuche V, Avila-Nava A, Palacios-González B, Gutiérrez-Solis AL. Micro- and Macronutrient Intake and Food Group Frequency Consumed by Subjects with Cognitive Impairment and Dementia in Latin America: A Systematic Review. Journal of Alzheimer's disease : JAD 2023. link 88 Dai M, Song Q, Wang X, Li Y, Lin T, Liang R et al.. Combined associations of vitamin D and cognitive function with all-cause mortality among older adults in Chinese longevity areas: A prospective cohort study. Frontiers in public health 2023. link 89 Economou A, Varlokosta S, Kontari P, Papageorgiou SG. The nonverbal BriefScreen: A cognitive screening method for patients with limited language and motor abilities. Applied neuropsychology. Adult 2023. link 90 Wang Z, Li T, Du M, Zhang L, Xu L, Song H et al.. β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage. Brain research bulletin 2023. link 91 Lineback CM, Stamm B, Sorond F, Caprio FZ. Carotid disease, cognition, and aging: time to redefine asymptomatic disease?. GeroScience 2023. link 92 Huang XT, Chen CY, Zhang QF, Lu LH, She YL, Fang XY. Meta-analysis of the efficacy of acupuncture in the treatment of the vascular cognitive impairment associated with cerebral small vessel disease. Explore (New York, N.Y.) 2023. link 93 Han X, Zhang J, Chen S, Yu W, Zhou Y, Gu X. Mapping the current trends and hotspots of vascular cognitive impairment from 2000-2021: A bibliometric analysis. CNS neuroscience & therapeutics 2023. link 94 Aarsland D, Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Holteng LBA et al.. A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2023. link 95 Tang X, Wei C, Zhang R, You J, Chen X. CCL21/CCR7 axis regulates demyelination and vascular cognitive impairment in a mouse model for chronic cerebral hypoperfusion. Neurological research 2023. link 96 Alexandratou A, Mah Y, Ramsey D, Kandasamy N, Tolias CM, Gadapa N et al.. Dural arteriovenous fistula causing reversible cognitive impairment. Practical neurology 2023. link 97 van Dinther M, Bennett J, Thornton GD, Voorter PHM, Ezponda Casajús A, Hughes A et al.. Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study. Cerebrovascular diseases extra 2023. link 98 Venegas-Sanabria LC, Cavero-Redondo I, Martínez-Vizcaino V, Cano-Gutierrez CA, Álvarez-Bueno C. Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis. BMC geriatrics 2022. link 99 Weber MA, Conlon MM, Stutt HR, Wendt L, Ten Eyck P, Narayanan NS. Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory. Behavioral neuroscience 2022. link 100 Tommasini NR, Iennaco JD. A Model Program to Manage Behavioral Emergencies and Support Nurses in the Medical Setting. Nursing administration quarterly 2022. link

    Original source

    1. [1]
      Characterizing Medicare Medication Therapy Management program enrollees with central nervous system-active polypharmacy.Hung A, Wilson LE, Smith VA, Erickson R, Tharpe K, Brandt N et al. Journal of managed care & specialty pharmacy (2026)
    2. [2]
    3. [3]
      Polypharmacy, Hyperpolypharmacy, and Associated Dementia: A Southeast Texas Nested Case-Control Study.Thompson J, Yu S, Vasefi M Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2026)
    4. [4]
      Subjective Memory Complaints in Older Adults: The Role of Polypharmacy and Anticholinergic Burden.Yavuz Veizi BG, Oğuz EO, Ilkin Naharci M Journal of geriatric psychiatry and neurology (2026)
    5. [5]
    6. [6]
      Targeting NADLi Z, Zhang HY, Feng R, Qi WX, Wang YT, Li Q et al. Stroke (2026)
    7. [7]
    8. [8]
      Integration of genetic risk, cardiometabolic diseases, and cognitive impairment among African American adults.Dagli C, Armstrong ND, Kim D, Raffield LM, Tiwari HK, Cushman M et al. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2026)
    9. [9]
    10. [10]
      Cardiometabolic indicators of cognitive impairment in the Cameron County Hispanic Cohort.Musfee FI, Agarwal S, Maroufy V, Liu C, McCormick JB, Fisher-Hoch S et al. Journal of Alzheimer's disease : JAD (2026)
    11. [11]
    12. [12]
      Association Between Gas-Free Cerebrovascular Reactivity (CVR) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia.Badrzadeh F, Karimigharighi E, Liang H, Chan A, Chang L, Liu P Journal of magnetic resonance imaging : JMRI (2026)
    13. [13]
    14. [14]
    15. [15]
    16. [16]
      Exploratory evaluation of CAP1 and ROCK2 as candidate blood biomarkers for vascular cognitive impairment.Ren X, Zhang X, Wang W, Zhang M, Bi X, Peng W Journal of Alzheimer's disease : JAD (2026)
    17. [17]
      Association of neighborhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study.Heikkilä K, Stenholm S, Pentti J, Vahtera J, Elovainio M, Pulkki-Råback L et al. American journal of epidemiology (2026)
    18. [18]
      Association of sleep duration with cognitive impairment: A mediation by metabolic factors and intracranial atherosclerosis.Zhang A, Chen H, Chen W, Cai X, Zhou M, Li S et al. Journal of Alzheimer's disease : JAD (2026)
    19. [19]
    20. [20]
    21. [21]
    22. [22]
    23. [23]
      Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance.Huang J, Chen C, Tan WY, Cui J, Chong EJY, Venketasubramanian N et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2026)
    24. [24]
    25. [25]
    26. [26]
      A new microinfarcts model produces widespread bilateral infarcts and persistent cognitive deficits in middle-aged mice.Liu Z, Mccann M, Powell B, Landschoot-Ward J, Zhang ZG, Chopp M Experimental neurology (2026)
    27. [27]
      (Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people.Li Y, Le Sayec M, Xu Y, Bergland AK, Khalifa K, de Lucia C et al. The Journal of nutritional biochemistry (2026)
    28. [28]
      Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.Swartz RH, Longman RS, Lindsay MP, Lund R, Ganesh A, Eskes GA et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2025)
    29. [29]
      A meta-analysis of technology use and cognitive aging.Benge JF, Scullin MK Nature human behaviour (2025)
    30. [30]
    31. [31]
    32. [32]
      Patient-Related Factors Associated With the Initiation of Potentially Inappropriate Medication in Home Care: An Observational Study Based on Resident Assessment Instrument Data.Paulamäki J, Jyrkkä J, Hyttinen-Huotari V, Huhtala H, Jämsen E Basic & clinical pharmacology & toxicology (2025)
    33. [33]
      Motoric cognitive risk syndrome: prevalence and associated sociodemographic and clinical factors in primary care settings in Brazil.Azevedo LVDS, Marques AMDS, Silva-Júnior GA, de Santos GSS, Faria LP, Taveira ML et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2025)
    34. [34]
      Polypharmacy and Mild Cognitive Impairment in Older Adults: A 3-year Study of DO-HEALTH.de Godoi Rezende Costa Molino C, Baumann K, Gaengler S, Meyer-Heim T, Sadlon A, Freystaetter G et al. Journal of the American Medical Directors Association (2025)
    35. [35]
      Preoperative cognitive impairment predicts deep anaesthesia and higher postoperative pain in elderly patients: an observational study.Runge J, Heedfeld RK, Grundmann CD, Wischermann JM, Bischoff P, Frey UH BMC anesthesiology (2025)
    36. [36]
      Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.Corbett A, Taylor R, Llewellyn D, Ranson JM, Hampshire A, Pickering E et al. Journal of the American Medical Directors Association (2025)
    37. [37]
    38. [38]
      Association Between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: The Ohasama Study.Yamazaki T, Nomura K, Satoh M, Hara A, Tsubota-Utsugi M, Murakami T et al. The Tohoku journal of experimental medicine (2025)
    39. [39]
      Complex interactions and composite burden of risk factors in vascular cognitive impairment.Ji L, Zhang J Journal of the neurological sciences (2025)
    40. [40]
      Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI).Li C, Zhang L, Li X, Hu Q, Mao L, Shao Y et al. The Journal of nutritional biochemistry (2025)
    41. [41]
    42. [42]
      WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.DeCarli C, Rajan KB, Jin LW, Hinman J, Johnson DK, Harvey D et al. Stroke (2025)
    43. [43]
    44. [44]
      Theta-burst transcranial magnetic stimulation attenuates chronic ischemic demyelination and vascular cognitive impairment in mice.Wang D, Zhang X, Huang Z, Li Y, Wang X, Wang J et al. Experimental neurology (2025)
    45. [45]
      VasCog Screen test: sensitive in detecting cognitive impairment in patients who had a stroke or with heart failure.Chen NYC, Tan MYL, Xu J, Zuo L, Dong Y Stroke and vascular neurology (2025)
    46. [46]
      Efficacy of Nonpharmacological Interventions in Cognitive Impairment: Systematic Review And Network Meta-Analysis.Venegas-Sanabria LC, Cavero-Redondo I, Lorenzo-Garcia P, Sánchez-Vanegas G, Álvarez-Bueno C The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2024)
    47. [47]
      Effects of cilostazol on cognitive function and dementia risk: A systematic review and meta-analysis.Cheng X, Ren Q, Zhi J, Chen Q, Luo K, Yu L et al. Medicine (2024)
    48. [48]
      Effects of Ginseng on Cognitive Function: A Systematic Review and Meta-Analysis.Zeng M, Zhang K, Yang J, Zhang Y, You P, Yan L et al. Phytotherapy research : PTR (2024)
    49. [49]
      Communication support in care homes for older adults: Views and reported practices of speech and language therapists and care home activities staff in the UK.Davis L, Botting N, Cruice M, Dipper L International journal of language & communication disorders (2024)
    50. [50]
      Best practices for implementing a technology-based intervention protocol: Participant and researcher considerations.Mois G, Lydon EA, Mathias VF, Jones SE, Mudar RA, Rogers WA Archives of gerontology and geriatrics (2024)
    51. [51]
      Reduction of Rehospitalization with Addition of Geriatrics/Transitions of Care Consult Service.Jackson AE, Brubaker AN, Coffey CR, Kalender-Rich JL Journal of the American Medical Directors Association (2024)
    52. [52]
      Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit.Hilsabeck RC, Perry W, Lacritz L, Arnett PA, Shah RC, Borson S et al. Annals of family medicine (2024)
    53. [53]
      Psychotropic Polypharmacy Leading to Reversible Dementia: A Case Report.Lahiri D, Seixas-Lima B, Roncero C, Stokes K, Panda SS, Chertkow H Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology (2024)
    54. [54]
      Association between polypharmacy and cognitive impairment in older adults: A systematic review and meta-analysis.Yu X, Qian Y, Zhang Y, Chen Y, Wang M Geriatric nursing (New York, N.Y.) (2024)
    55. [55]
      Anticholinergic and sedative medication use in older patients with cognitive concerns.Hinkle CE, Davis JD, Arias I, Goldstein A, Daiello L, Margolis SA Journal of the American Geriatrics Society (2024)
    56. [56]
      Pain and incident cognitive impairment in very old Mexican American adults.Milani SA, Sanchez C, Kuo YF, Downer B, Al Snih S, Markides KS et al. Journal of the American Geriatrics Society (2024)
    57. [57]
      The Prevalence of Cognitive Impairment Among Medicare Beneficiaries Who Use Outpatient Physical Therapy.Miller MJ, Cenzer I, Barnes DE, Kelley AS, Covinsky KE Physical therapy (2024)
    58. [58]
      Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Voltas-Moreso N, Arija V Maternal & child nutrition (2024)
    59. [59]
      Vascular risk, gait, behavioral, and plasma indicators of VCID.Raghavan S, Przybelski SA, Lesnick TG, Fought AJ, Reid RI, Gebre RK et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
    60. [60]
      A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design.Davidy T, Yore I, Cukierman-Yaffe T, Ravona-Springer R, Livny A, Lesman-Segev OH et al. Mechanisms of ageing and development (2024)
    61. [61]
      Detection of Cognitive Impairment From eSAGE Metadata Using Machine Learning.Kawakami R, Wright KD, Scharre DW, Ning X Alzheimer disease and associated disorders (2024)
    62. [62]
      Exercise Improves Cerebral Blood Flow and Functional Outcomes in an Experimental Mouse Model of Vascular Cognitive Impairment and Dementia (VCID).Khan MB, Alam H, Siddiqui S, Shaikh MF, Sharma A, Rehman A et al. Translational stroke research (2024)
    63. [63]
      Mid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women.Song Y, Wu F, Sharma S, Clendenen TV, India-Aldana S, Afanasyeva Y et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
    64. [64]
    65. [65]
      Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies.Duval GT, Raud E, Gohier H, Dramé M, Tabue-Teguo M, Annweiler C Maturitas (2024)
    66. [66]
      Time-lagged associations between two adverse childhood experiences and later-life cognitive function through educational attainment and stroke.Kraal AZ, Zaheed AB, Krasnova A, Vadari H, Byrd DR, Zahodne LB Journal of the International Neuropsychological Society : JINS (2024)
    67. [67]
      Relationship between blood pressure and cognitive impairment in elderly outpatients with cardiometabolic diseases.Ishikawa J, Toba A, Tamura Y, Araki A, Harada K Geriatrics & gerontology international (2024)
    68. [68]
    69. [69]
      Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?García-Culebras A, Cuartero MI, Peña-Martínez C, Moraga A, Vázquez-Reyes S, de Castro-Millán FJ et al. British journal of pharmacology (2024)
    70. [70]
      Trends in the prevalence of cognitive impairment at old age in China, 2002-2018.Chen H, Ye KX, Feng Q, Cao K, Yu J, Li C et al. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
    71. [71]
      Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis.Starmans NLP, Kappelle LJ, Muller M, Staals J, Teunissen CE, Biessels GJ et al. Journal of Alzheimer's disease : JAD (2024)
    72. [72]
      Cognitive stimulation and cognitive results in older adults: A systematic review and meta-analysis.Gómez-Soria I, Iguacel I, Aguilar-Latorre A, Peralta-Marrupe P, Latorre E, Zaldívar JNC et al. Archives of gerontology and geriatrics (2023)
    73. [73]
      Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis.Bonvicini M, Travaglini S, Lelli D, Antonelli Incalzi R, Pedone C Nutrients (2023)
    74. [74]
      Can Traditional Board Games Prevent or Slow Down Cognitive Impairment? A Systematic Review and Meta-Analysis.Pozzi FE, Appollonio I, Ferrarese C, Tremolizzo L Journal of Alzheimer's disease : JAD (2023)
    75. [75]
    76. [76]
      Cognitive impairment and behavioural emergencies within the acute hospital setting.Ilievski V, Barrett T, Lawson W, Hoyland S, Tran K BMJ open quality (2023)
    77. [77]
    78. [78]
      Perioperative neurocognitive disorders.Connal S British journal of hospital medicine (London, England : 2005) (2023)
    79. [79]
    80. [80]
      Navigating and diagnosing cognitive frailty in research and clinical domains.Nader MM, Cosarderelioglu C, Miao E, Whitson H, Xue QL, Grodstein F et al. Nature aging (2023)
    81. [81]
    82. [82]
      Intervention design in cognitively impaired populations-Lessons learned from the OPTIMIZE deprescribing pragmatic trial.Sheehan OC, Gleason KS, Bayliss EA, Green AR, Drace ML, Norton J et al. Journal of the American Geriatrics Society (2023)
    83. [83]
      Willingness of older people living with dementia and mild cognitive impairment and their caregivers to have medications deprescribed.Reeve E, Bayliss EA, Shetterly S, Maiyani M, Gleason KS, Norton JD et al. Age and ageing (2023)
    84. [84]
      End-of-life health care use among socially isolated and cognitively impaired older adults.Kotwal AA, Cenzer IS, Yaffe K, Perissinotto C, Smith AK Journal of the American Geriatrics Society (2023)
    85. [85]
      Serum Vitamin D Status and Cognitive Function in Iranian Older Adults: Evidence from the Birjand Longitudinal Aging Study.Barmaki O, Mansour A, Moodi M, Mirahmad M, Fakhrzadeh H, Arzaghi M et al. The Journal of nutrition (2023)
    86. [86]
      Association between vitamin BAguilar-Navarro SG, Carbajal-Silva JC, Palacios-Hernández MGI, Gutiérrez-Gutierrez LA, Ávila-Funes JA, Mimenza-Alvarado AJ Gaceta medica de Mexico (2023)
    87. [87]
      Micro- and Macronutrient Intake and Food Group Frequency Consumed by Subjects with Cognitive Impairment and Dementia in Latin America: A Systematic Review.Garrido-Dzib AG, Chávez-Loría G, Magallón-Zertuche V, Avila-Nava A, Palacios-González B, Gutiérrez-Solis AL Journal of Alzheimer's disease : JAD (2023)
    88. [88]
    89. [89]
      The nonverbal BriefScreen: A cognitive screening method for patients with limited language and motor abilities.Economou A, Varlokosta S, Kontari P, Papageorgiou SG Applied neuropsychology. Adult (2023)
    90. [90]
    91. [91]
      Carotid disease, cognition, and aging: time to redefine asymptomatic disease?Lineback CM, Stamm B, Sorond F, Caprio FZ GeroScience (2023)
    92. [92]
    93. [93]
      Mapping the current trends and hotspots of vascular cognitive impairment from 2000-2021: A bibliometric analysis.Han X, Zhang J, Chen S, Yu W, Zhou Y, Gu X CNS neuroscience & therapeutics (2023)
    94. [94]
      A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia.Aarsland D, Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Holteng LBA et al. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2023)
    95. [95]
    96. [96]
      Dural arteriovenous fistula causing reversible cognitive impairment.Alexandratou A, Mah Y, Ramsey D, Kandasamy N, Tolias CM, Gadapa N et al. Practical neurology (2023)
    97. [97]
      Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study.van Dinther M, Bennett J, Thornton GD, Voorter PHM, Ezponda Casajús A, Hughes A et al. Cerebrovascular diseases extra (2023)
    98. [98]
      Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis.Venegas-Sanabria LC, Cavero-Redondo I, Martínez-Vizcaino V, Cano-Gutierrez CA, Álvarez-Bueno C BMC geriatrics (2022)
    99. [99]
      Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.Weber MA, Conlon MM, Stutt HR, Wendt L, Ten Eyck P, Narayanan NS Behavioral neuroscience (2022)
    100. [100]
      A Model Program to Manage Behavioral Emergencies and Support Nurses in the Medical Setting.Tommasini NR, Iennaco JD Nursing administration quarterly (2022)

    HemoChat

    by SPINAI

    Evidence-based clinical decision support powered by SNOMED-CT, Neo4j GraphRAG, and NASS/AO/NICE guidelines.

    ⚕ For clinical reference only. Not a substitute for professional judgment.

    © 2026 HemoChat. All rights reserved.
    Research·Pricing·Privacy & Terms·Refund·SNOMED-CT · NASS · AO Spine · NICE · GraphRAG