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Palliative Care425 papers

Advanced cirrhosis

Last edited: 4/17/2026

Overview

Advanced cirrhosis represents a severe stage of liver disease characterized by significant liver dysfunction, portal hypertension, and increased risk of complications such as variceal bleeding, ascites, encephalopathy, and hepatorenal syndrome. Effective management focuses on symptom control, prevention of complications, and addressing quality of life.

Diagnosis

Clinical features: Jaundice, ascites, spider angiomas, palmar erythema, and signs of portal hypertension.

Laboratory tests: Elevated INR, low albumin, elevated bilirubin, and prolonged prothrombin time.

Imaging: Ultrasound or CT scan to assess liver morphology and portal vein patency.

Diagnostic procedures: Paracentesis for ascites analysis, endoscopy for varices detection 1 2 3 4.

Management

Symptom Control:

- Pain management: Opioids (e.g., morphine) titrated to effect; consider non-opioid adjuncts like gabapentin 5 6. - Ascites: Diuretics (e.g., spironolactone, furosemide) to manage fluid retention 7. - Hepatic encephalopathy: Lactulose, rifaximin for ammonia reduction 8.

Complication Prevention:

- Variceal bleeding prophylaxis: Non-selective beta-blockers (e.g., propranolol) 9. - Infection prevention: Regular monitoring and prompt antibiotic therapy for suspected infections 10.

Deprescribing: Evaluate and taper unnecessary medications to reduce polypharmacy risks 22 29 30.

Special Populations

Elderly: Increased risk of polypharmacy and adverse drug events; prioritize deprescribing and symptom-focused care 22 30.

Comorbidities: Manage comorbidities like cardiovascular disease cautiously, considering drug interactions and organ function 2 4 10.

Key Recommendations

Prioritize comprehensive symptom management, including opioid therapy for pain and non-pharmacological approaches for distress 5 6.

Implement deprescribing strategies to minimize medication burden and reduce adverse events in patients with limited life expectancy 22 29.

Early integration of palliative care to address psychological, social, and spiritual needs alongside medical management 1 19 31.

Regularly assess and manage complications such as ascites and variceal bleeding to improve quality of life 7 9.

Engage in goals-of-care discussions early to align treatment with patient preferences and values 11 51.

(Evidence: Moderate)

References

Showing 100 most recent of 145 indexed papers.

1 Hamza Habib M, Zheng J, Kozlov E, Peng-Keller S, Ciurea A, Schildmann J et al.. Top Ten Tips Palliative Care Clinicians Should Know About Total Pain. Journal of palliative medicine 2026. link 2 Correa-Morales JE, Johansson T, Curtis T, Murtagh FEM, Davies JM, Sleeman KE. Financial status and pain in the last week of life: Insights from a nationally representative mortality follow-back survey in England and Wales. The journal of pain 2026. link 3 Chan MC, Lin CF, Wu JJ, Wang CL, Lai SY, Hsu WT et al.. Pain and Fatigue Interrelations in Terminally Ill Inpatients: A PCOC-Based Analysis. Journal of pain and symptom management 2026. link 4 Xu L, Xie RX, Cai SS, Yang DF, Wu CG, Wang CH. Adverse events associated with the use of nivolumab in the middle-aged and older population (>45 years): A pharmacovigilance analysis based on the FAERS database. Medicine 2026. link 5 Boland JW, Boland EG. How to distinguish opioid toxicity from natural dying in patients with advanced illness and how to manage opioid toxicity?. Clinical medicine (London, England) 2025. link 6 Bergman J, Filippou P, Suskind AM, Johnson K, Calvert E, Fero K et al.. Primary Palliative Care in Urology: Quality Improvement Summit 2021-2022. Urology practice 2024. link 7 Caplan H, Santos J, Bershad M, Spritzer K, Liantonio J. Assessment of Feelings Towards Advanced Care Planning in the Latino Community. The American journal of hospice & palliative care 2024. link 8 Duffy E, O'Mahony F, Burke C, Conneely A, O'Connell H, Twomey F. Red cell transfusion benefits in oncology, haematology and palliative medicine populations: a narrative review. BMJ supportive & palliative care 2023. link 9 Shrestha S, Poudel A, Forough AS, Steadman KJ, Nissen LM. A systematic review on methods for developing and validating deprescribing tools for older adults with limited life expectancy. The International journal of pharmacy practice 2023. link 10 Alshammari F, Sim J, Mcerlean G, Lapkin S. Registered Nurses' beliefs about end-of-life care: A mixed method study. Nursing open 2023. link 11 Abdelaal M, Avery J, Chow R, Saleem N, Fazelzad R, Mosher P et al.. Palliative care for adolescents and young adults with advanced illness: A scoping review. Palliative medicine 2023. link 12 Martí-García C, Fernández-Férez A, Fernández-Sola C, Pérez-Rodríguez R, Esteban-Burgos AA, Hernández-Padilla JM et al.. Patients' experiences and perceptions of dignity in end-of-life care in emergency departments: A qualitative study. Journal of advanced nursing 2023. link 13 Osakwe ZT, Oni-Eseleh O, Rosati RJ, Stefancic A. "The Crossover to Hospice": Perspectives of Home Healthcare Nurses and Social Workers. The American journal of hospice & palliative care 2023. link 14 Islam Z, Pollock K, Patterson A, Hanjari M, Wallace L, Mururajani I et al.. Thinking ahead about medical treatments in advanced illness: a qualitative study of barriers and enablers in end-of-life care planning with patients and families from ethnically diverse backgrounds. Health and social care delivery research 2023. link 15 Clarke G, Crooks J, Bennett MI, Mirza Z, Obe RB, Nazar W et al.. Experiences of pain and pain management in advanced disease and serious illness for people from South Asian communities in Leeds and Bradford: a qualitative interview study. BMC palliative care 2023. link 16 Brickey J, Flannery M, Cuthel A, Cho J, Grudzen CR. Barriers to recruitment into emergency department-initiated palliative care: a sub-study of a multi-site, randomized controlled trial. BMC palliative care 2022. link 17 Brandl A, Lundon D, Lorenzon L, Schrage Y, Caballero C, Holmberg CJ et al.. Standards in surgical training in advanced pelvic malignancy across Europe and beyond - A Snapshot analysis. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2022. link 18 McGraw C. Involving older people in decisions about deprescribing in end of life care. Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2022. link 19 Quinn BG. Providing palliative and end of life care for people with advanced disease. Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2022. link 20 Guo P, Pinto C, Edwards B, Pask S, Firth A, O'Brien S et al.. Experiences of transitioning between settings of care from the perspectives of patients with advanced illness receiving specialist palliative care and their family caregivers: A qualitative interview study. Palliative medicine 2022. link 21 Walsh A. Palliative Wound Care: Case Studies. Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association 2022. link 22 Clarke G, Chapman E, Crooks J, Koffman J, Ahmed S, Bennett MI. Does ethnicity affect pain management for people with advanced disease? A mixed methods cross-national systematic review of 'very high' Human Development Index English-speaking countries. BMC palliative care 2022. link 23 Donati CM, Macchia G, Siepe G, Zamagni A, Benini A, Cellini F et al.. Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project). Scientific reports 2022. link 24 Woods E, Baker L, Hindmarsh J. Norepinephrine pressor infusion withdrawal in a National Health Service hospice. BMJ supportive & palliative care 2022. link 25 Haider S, Descallar J, Moylan E, Chua W. Polypharmacy and the use of low or limited value medications in advanced cancer. Internal medicine journal 2021. link 26 Taber JM, Stacey CL, Sheehan DK. Understanding Hospice Patients' Beliefs About Their Life Expectancy: A Qualitative Interview Study. The American journal of hospice & palliative care 2021. link 27 Meyer-Junco L. Time to Deprescribe: A Time-Centric Model for Deprescribing at End of Life. Journal of palliative medicine 2021. link 28 Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano S et al.. Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology. International journal of clinical oncology 2020. link 29 Vázquez-García D, De-la-Rica-Escuín M, Germán-Bes C, Caballero-Navarro AL. Deaths in hospital emergency departments in Aragon: patient characteristics and association with comorbidity. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias 2020. link 30 Cardona M, Williamson M, Jones M, Ní Chróinín D, Gullotta J, Hillman K et al.. It is feasible to flag 'near end-of-life' status in older patients from routine general practice data. Australian journal of general practice 2020. link 31 Pesut B, Duggleby W, Warner G, Kervin E, Bruce P, Antifeau E et al.. Implementing volunteer-navigation for older persons with advanced chronic illness (Nav-CARE): a knowledge to action study. BMC palliative care 2020. link 32 Talebreza S, McPherson ML. Recognizing and Managing Polypharmacy in Advanced Illness. The Medical clinics of North America 2020. link 33 Akgün KM, Krishnan S, Feder SL, Tate J, Kutner JS, Crothers K. Polypharmacy Increases Risk of Dyspnea Among Adults With Serious, Life-Limiting Diseases. The American journal of hospice & palliative care 2020. link 34 Jennings N, Chambaere K, Chamely S, Macpherson CC, Deliens L, Cohen J. Palliative and End-of-Life Care in a Small Caribbean Country: A Mortality Follow-back Study of Home Deaths. Journal of pain and symptom management 2020. link 35 Intrator O, Li J, Gillespie SM, Levy C, Davis D, Edes T et al.. Benchmarking Site of Death and Hospice Use: A Case Study of Veterans Cared by Department of Veterans Affairs Home-based Primary Care. Medical care 2020. link 36 Torke AM, Fitchett G, Maiko S, Burke ES, Slaven JE, Watson BN et al.. The Association of Surrogate Decision Makers' Religious and Spiritual Beliefs With End-of-Life Decisions. Journal of pain and symptom management 2020. link 37 Fu J, Zeng Y, Tan Y, Fu B, Qiu H. Effects of hospice care on quality of life and negative emotions in patients with advanced tumor: A protocol for systematic review and meta-analysis. Medicine 2020. link 38 Chou CZ, Hopkins TJ, Badiola I, Gazelka HM, Gohil S, Kitt A et al.. Top Ten Tips Palliative Care Clinicians Should Know About Interventional Pain and Procedures. Journal of palliative medicine 2020. link 39 Fedorowsky R, Bachner YG, Borer A, Ciobotaro P, Kushnir T. Use of antibiotics among end-of-life hospitalized patients with advanced directives: Status examination and association with infectious disease consultation and physician burnout. Infection control and hospital epidemiology 2019. link 40 Dunn SH, Rogal SS, Maier MM, Chartier M, Morgan TR, Beste LA. Access to Comprehensive Services for Advanced Liver Disease in the Veterans Health Administration. Digestive diseases and sciences 2019. link 41 Mogul AS, Cline DM, Gabbard J, Bryant C. Missed Opportunities: Integrating Palliative Care into the Emergency Department for Older Adults Presenting as Level I Triage Priority from Long-Term Care Facilities. The Journal of emergency medicine 2019. link 42 Parekh N, Schenker Y, Good CB, Neilson L, Shrank WH. Deprescribing in Advanced Illness: Aligning Patient, Clinician, and Health Plan Goals. Journal of general internal medicine 2019. link 43 Pasina L, Brignolo Ottolini B, Cortesi L, Tettamanti M, Franchi C, Marengoni A et al.. Need for Deprescribing in Hospital Elderly Patients Discharged with a Limited Life Expectancy: The REPOSI Study. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2019. link 44 Schlick CJR, Bentrem DJ. Timing of palliative care: When to call for a palliative care consult. Journal of surgical oncology 2019. link 45 Duncan I, Ahmed T, Dove H, Maxwell TL. Medicare Cost at End of Life. The American journal of hospice & palliative care 2019. link 46 Dhingra L, Lipson K, Dieckmann NF, Chen J, Bookbinder M, Portenoy R. Institutional Special Needs Plans and Hospice Enrollment in Nursing Homes: A National Analysis. Journal of the American Geriatrics Society 2019. link 47 Riggs A, Breuer B, Patel V, Harounian J, Chen J, Dhingra L et al.. Pain-related distress among patients referred to a community-based palliative care program. Palliative & supportive care 2019. link 48 Edwards H, Bennett M. Access to Opioids for Patients with Advanced Disease. Current pharmaceutical design 2019. link 49 Huynh MA, Spektor A. Translational and basic science opportunities in palliative care and radiation oncology. Annals of palliative medicine 2019. link 50 Kohutek F, Katrlik J, Bystricky B. Hypotension as a symptom of autonomic neuropathy in patients with advanced malignancies. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2019. link 51 Liberman T, Kozikowski A, Kwon N, Emmert B, Akerman M, Pekmezaris R. Identifying Advanced Illness Patients in the Emergency Department and Having Goals-of-Care Discussions to Assist with Early Hospice Referral. The Journal of emergency medicine 2018. link 52 Curlin FA. Palliative sedation: clinical context and ethical questions. Theoretical medicine and bioethics 2018. link 53 Sevilla-Sánchez D, Molist-Brunet N, González-Bueno J, Solà-Bonada N, Espaulella-Panicot J, Codina-Jané C. Prevalence, risk factors and adverse outcomes of anticholinergic burden in patients with advanced chronic conditions at hospital admission. Geriatrics & gerontology international 2018. link 54 Fine PG. Hospice Underutilization in the U.S.: The Misalignment of Regulatory Policy and Clinical Reality. Journal of pain and symptom management 2018. link 55 Phongtankuel V, Meador L, Adelman RD, Roberts J, Henderson CR, Mehta SS et al.. Multicomponent Palliative Care Interventions in Advanced Chronic Diseases: A Systematic Review. The American journal of hospice & palliative care 2018. link 56 Richter C. Implementation of a Clinical Pharmacist Service in the Hospice Setting: Financial and Clinical Impacts. Journal of pain & palliative care pharmacotherapy 2018. link 57 Fitzpatrick J, Mavissakalian M, Luciani T, Xu Y, Mazurek A. Economic Impact of Early Inpatient Palliative Care Intervention in a Community Hospital Setting. Journal of palliative medicine 2018. link 58 Romero-Brufau S, Whitford D, Whitford KJ, Manning DM, Huddleston JM. Identifying patients at risk of inhospital death or hospice transfer for early goals of care discussions in a US referral center: the HELPS model derived from retrospective data. BMJ open 2018. link 59 Allsop MJ, Ziegler LE, Mulvey MR, Russell S, Taylor R, Bennett MI. Duration and determinants of hospice-based specialist palliative care: A national retrospective cohort study. Palliative medicine 2018. link 60 Frush BW, Brauer SG, Yoon JD, Curlin FA. Physician Decision-Making in the Setting of Advanced Illness: An Examination of Patient Disposition and Physician Religiousness. Journal of pain and symptom management 2018. link 61 Sagha Zadeh R, Capezuti E, Eshelman P, Woody N, Tiffany J, Krieger AC. Non-pharmacological solutions to sleep and circadian rhythm disruption: voiced bedside experiences of hospice and end-of-life staff caregivers. BMC palliative care 2018. link 62 Masman AD, van Dijk M, van Rosmalen J, Baar FPM, Tibboel D, Boerlage AA. The Rotterdam Elderly Pain Observation Scale (REPOS) is reliable and valid for non-communicative end-of-life patients. BMC palliative care 2018. link 63 Sevilla-Sanchez D, Molist-Brunet N, Amblàs-Novellas J, Roura-Poch P, Espaulella-Panicot J, Codina-Jané C. Adverse drug events in patients with advanced chronic conditions who have a prognosis of limited life expectancy at hospital admission. European journal of clinical pharmacology 2017. link 64 Sevilla-Sánchez D, Molist-Brunet N, Amblàs-Novellas J, Espaulella-Panicot J, Codina-Jané C. Potentially inappropriate medication at hospital admission in patients with palliative care needs. International journal of clinical pharmacy 2017. link 65 Eastman P, Dowd A, Goonan J, Farrell H, Pitson G. Palliative radiotherapy utilization within a regional Australian palliative care unit. Annals of palliative medicine 2017. link 66 Temkin-Greener H, Ladwig S, Ye Z, Norton SA, Mukamel DB. Improving palliative care through teamwork (IMPACTT) in nursing homes: Study design and baseline findings. Contemporary clinical trials 2017. link 67 Burns J, Jackson K, Sheehy KA, Finkel JC, Quezado ZM. The Use of Dexmedetomidine in Pediatric Palliative Care: A Preliminary Study. Journal of palliative medicine 2017. link 68 Bern-Klug M. Considering the CPR Decision Through the Lens of Prospect Theory in the Context of Advanced Chronic Illness. The Gerontologist 2017. link 69 Abrashkin KA, Washko J, Zhang J, Poku A, Kim H, Smith KL. Providing Acute Care at Home: Community Paramedics Enhance an Advanced Illness Management Program-Preliminary Data. Journal of the American Geriatrics Society 2016. link 70 Golden AG, Antoni C, Gammonley D. A Home-Based Palliative Care Consult Service for Veterans. The American journal of hospice & palliative care 2016. link 71 McNeil MJ, Kamal AH, Kutner JS, Ritchie CS, Abernethy AP. The Burden of Polypharmacy in Patients Near the End of Life. Journal of pain and symptom management 2016. link 72 Boucher NA, Nix H. The benefits of expanded physician assistant practice in hospice and palliative medicine. JAAPA : official journal of the American Academy of Physician Assistants 2016. link 73 Harrison KL, Connor SR. First Medicare Demonstration of Concurrent Provision of Curative and Hospice Services for End-of-Life Care. American journal of public health 2016. link 74 Washington KT, Oliver DP, Gage LA, Albright DL, Demiris G. A multimethod analysis of shared decision-making in hospice interdisciplinary team meetings including family caregivers. Palliative medicine 2016. link 75 Gustin AN, Aslakson RA. Palliative Care for the Geriatric Anesthesiologist. Anesthesiology clinics 2015. link 76 Black K, Csikai EL. Dying in the age of choice. Journal of social work in end-of-life & palliative care 2015. link 77 Davis MS, Harrison KL, Rice JF, Logan A, Hess B, Fine PG et al.. A Model for Effective and Efficient Hospice Care: Proactive Telephone-Based Enhancement of Life Through Excellent Caring, "TeleCaring" in Advanced Illness. Journal of pain and symptom management 2015. link 78 Washington KT, Pike KC, Demiris G, Parker Oliver D, Albright DL, Lewis AM. Gender Differences in Caregiving at End of Life: Implications for Hospice Teams. Journal of palliative medicine 2015. link 79 Rajagopal MR, Ito K. Pain in Bali. Journal of pain & palliative care pharmacotherapy 2015. link 80 Chen TW, Razak AR, Bedard PL, Siu LL, Hansen AR. A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors. Annals of oncology : official journal of the European Society for Medical Oncology 2015. link 81 Ashworth E. Utilizing participation in meaningful occupation as an intervention approach to support the acute model of inpatient palliative care. Palliative & supportive care 2014. link 82 Scheffey C, Kestenbaum MG, Wachterman MW, Connor SR, Fine PG, Davis MS et al.. Clinic-based outpatient palliative care before hospice is associated with longer hospice length of service. Journal of pain and symptom management 2014. link 83 Paris J, Morrison RS. Evaluating the effects of inpatient palliative care consultations on subsequent hospice use and place of death in patients with advanced GI cancers. Journal of oncology practice 2014. link 84 Harris DG. Management of pain in advanced disease. British medical bulletin 2014. link 85 Bendell JC, Gordon MS, Hurwitz HI, Jones SF, Mendelson DS, Blobe GC et al.. Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 2014. link 86 Cohen RB, Aamdal S, Nyakas M, Cavallin M, Green D, Learoyd M et al.. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. European journal of cancer (Oxford, England : 1990) 2013. link 87 Combs S, Kluger BM, Kutner JS. Research priorities in geriatric palliative care: nonpain symptoms. Journal of palliative medicine 2013. link 88 . Report of the Geriatrics-Hospice and Palliative Medicine Work Group: American Geriatrics Society and American Academy of Hospice and Palliative Medicine leadership collaboration. Journal of the American Geriatrics Society 2012. link 89 Cruz-Jentoft AJ, Boland B, Rexach L. Drug therapy optimization at the end of life. Drugs & aging 2012. link 90 Boelk AZ, Kramer BJ. Advancing theory of family conflict at the end of life: a hospice case study. Journal of pain and symptom management 2012. link 91 Kerr CW, Drake J, Milch RA, Brazeau DA, Skretny JA, Brazeau GA et al.. Effects of methylphenidate on fatigue and depression: a randomized, double-blind, placebo-controlled trial. Journal of pain and symptom management 2012. link 92 Wong SY, Lo SH, Chan CH, Chui HS, Sze WK, Tung Y. Is it feasible to discuss an advance directive with a Chinese patient with advanced malignancy? A prospective cohort study. Hong Kong medical journal = Xianggang yi xue za zhi 2012. link 93 Aragon K, Covinsky K, Miao Y, Boscardin WJ, Flint L, Smith AK. Use of the Medicare posthospitalization skilled nursing benefit in the last 6 months of life. Archives of internal medicine 2012. link 94 Speranza G, Gutierrez ME, Kummar S, Strong JM, Parker RJ, Collins J et al.. Phase I study of the synthetic triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), in advanced solid tumors. Cancer chemotherapy and pharmacology 2012. link 95 Youngwerth JM, Bartley JB, Yamashita TE, Kutner JS. Characteristics associated with higher cost per day or longer length of stay in hospitalized patients who died during the hospitalization or were discharged to hospice. Journal of hospital medicine 2011. link 96 Dy SM, Roy J, Ott GE, McHale M, Kennedy C, Kutner JS et al.. Tell Us™: a Web-based tool for improving communication among patients, families, and providers in hospice and palliative care through systematic data specification, collection, and use. Journal of pain and symptom management 2011. link 97 Abrahm JL. Advances in palliative medicine and end-of-life care. Annual review of medicine 2011. link 98 Mercadante S, Villari P, Ferrera P. Refractory death rattle: deep aspiration facilitates the effects of antisecretory agents. Journal of pain and symptom management 2011. link 99 Barnes D. Breathlessness in advanced disease. 1: Definitions, epidemiology and pathophysiology. Nursing times 2010. link 100 Kellum A, Jagiello-Gruszfeld A, Bondarenko IN, Patwardhan R, Messam C, Mostafa Kamel Y. A randomized, double-blind, placebo-controlled, dose ranging study to assess the efficacy and safety of eltrombopag in patients receiving carboplatin/paclitaxel for advanced solid tumors. Current medical research and opinion 2010. link

Original source

[1]
Top Ten Tips Palliative Care Clinicians Should Know About Total Pain. — Hamza Habib M, Zheng J, Kozlov E, Peng-Keller S, Ciurea A, Schildmann J et al. Journal of palliative medicine (2026)
[2]
Financial status and pain in the last week of life: Insights from a nationally representative mortality follow-back survey in England and Wales. — Correa-Morales JE, Johansson T, Curtis T, Murtagh FEM, Davies JM, Sleeman KE The journal of pain (2026)
[3]
Pain and Fatigue Interrelations in Terminally Ill Inpatients: A PCOC-Based Analysis. — Chan MC, Lin CF, Wu JJ, Wang CL, Lai SY, Hsu WT et al. Journal of pain and symptom management (2026)
[4]
Adverse events associated with the use of nivolumab in the middle-aged and older population (>45 years): A pharmacovigilance analysis based on the FAERS database. — Xu L, Xie RX, Cai SS, Yang DF, Wu CG, Wang CH Medicine (2026)
[5]
How to distinguish opioid toxicity from natural dying in patients with advanced illness and how to manage opioid toxicity? — Boland JW, Boland EG Clinical medicine (London, England) (2025)
[6]
Primary Palliative Care in Urology: Quality Improvement Summit 2021-2022. — Bergman J, Filippou P, Suskind AM, Johnson K, Calvert E, Fero K et al. Urology practice (2024)
[7]
Assessment of Feelings Towards Advanced Care Planning in the Latino Community. — Caplan H, Santos J, Bershad M, Spritzer K, Liantonio J The American journal of hospice & palliative care (2024)
[8]
Red cell transfusion benefits in oncology, haematology and palliative medicine populations: a narrative review. — Duffy E, O'Mahony F, Burke C, Conneely A, O'Connell H, Twomey F BMJ supportive & palliative care (2023)
[9]
A systematic review on methods for developing and validating deprescribing tools for older adults with limited life expectancy. — Shrestha S, Poudel A, Forough AS, Steadman KJ, Nissen LM The International journal of pharmacy practice (2023)
[10]
Registered Nurses' beliefs about end-of-life care: A mixed method study. — Alshammari F, Sim J, Mcerlean G, Lapkin S Nursing open (2023)
[11]
Palliative care for adolescents and young adults with advanced illness: A scoping review. — Abdelaal M, Avery J, Chow R, Saleem N, Fazelzad R, Mosher P et al. Palliative medicine (2023)
[12]
Patients' experiences and perceptions of dignity in end-of-life care in emergency departments: A qualitative study. — Martí-García C, Fernández-Férez A, Fernández-Sola C, Pérez-Rodríguez R, Esteban-Burgos AA, Hernández-Padilla JM et al. Journal of advanced nursing (2023)
[13]
"The Crossover to Hospice": Perspectives of Home Healthcare Nurses and Social Workers. — Osakwe ZT, Oni-Eseleh O, Rosati RJ, Stefancic A The American journal of hospice & palliative care (2023)
[14]
Thinking ahead about medical treatments in advanced illness: a qualitative study of barriers and enablers in end-of-life care planning with patients and families from ethnically diverse backgrounds. — Islam Z, Pollock K, Patterson A, Hanjari M, Wallace L, Mururajani I et al. Health and social care delivery research (2023)
[15]
Experiences of pain and pain management in advanced disease and serious illness for people from South Asian communities in Leeds and Bradford: a qualitative interview study. — Clarke G, Crooks J, Bennett MI, Mirza Z, Obe RB, Nazar W et al. BMC palliative care (2023)
[16]
Barriers to recruitment into emergency department-initiated palliative care: a sub-study of a multi-site, randomized controlled trial. — Brickey J, Flannery M, Cuthel A, Cho J, Grudzen CR BMC palliative care (2022)
[17]
Standards in surgical training in advanced pelvic malignancy across Europe and beyond - A Snapshot analysis. — Brandl A, Lundon D, Lorenzon L, Schrage Y, Caballero C, Holmberg CJ et al. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2022)
[18]
Involving older people in decisions about deprescribing in end of life care. — McGraw C Nursing standard (Royal College of Nursing (Great Britain) : 1987) (2022)
[19]
Providing palliative and end of life care for people with advanced disease. — Quinn BG Nursing standard (Royal College of Nursing (Great Britain) : 1987) (2022)
[20]
Experiences of transitioning between settings of care from the perspectives of patients with advanced illness receiving specialist palliative care and their family caregivers: A qualitative interview study. — Guo P, Pinto C, Edwards B, Pask S, Firth A, O'Brien S et al. Palliative medicine (2022)
[21]
Palliative Wound Care: Case Studies. — Walsh A Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association (2022)
[22]
Does ethnicity affect pain management for people with advanced disease? A mixed methods cross-national systematic review of 'very high' Human Development Index English-speaking countries. — Clarke G, Chapman E, Crooks J, Koffman J, Ahmed S, Bennett MI BMC palliative care (2022)
[23]
Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project). — Donati CM, Macchia G, Siepe G, Zamagni A, Benini A, Cellini F et al. Scientific reports (2022)
[24]
Norepinephrine pressor infusion withdrawal in a National Health Service hospice. — Woods E, Baker L, Hindmarsh J BMJ supportive & palliative care (2022)
[25]
Polypharmacy and the use of low or limited value medications in advanced cancer. — Haider S, Descallar J, Moylan E, Chua W Internal medicine journal (2021)
[26]
Understanding Hospice Patients' Beliefs About Their Life Expectancy: A Qualitative Interview Study. — Taber JM, Stacey CL, Sheehan DK The American journal of hospice & palliative care (2021)
[27]
Time to Deprescribe: A Time-Centric Model for Deprescribing at End of Life. — Meyer-Junco L Journal of palliative medicine (2021)
[28]
Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology. — Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano S et al. International journal of clinical oncology (2020)
[29]
Deaths in hospital emergency departments in Aragon: patient characteristics and association with comorbidity. — Vázquez-García D, De-la-Rica-Escuín M, Germán-Bes C, Caballero-Navarro AL Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias (2020)
[30]
It is feasible to flag 'near end-of-life' status in older patients from routine general practice data. — Cardona M, Williamson M, Jones M, Ní Chróinín D, Gullotta J, Hillman K et al. Australian journal of general practice (2020)
[31]
Implementing volunteer-navigation for older persons with advanced chronic illness (Nav-CARE): a knowledge to action study. — Pesut B, Duggleby W, Warner G, Kervin E, Bruce P, Antifeau E et al. BMC palliative care (2020)
[32]
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