Overview
Oligometastatic malignant neoplasms refer to a limited number of metastatic sites, often treated with a combination of local therapy (e.g., radiotherapy) and systemic treatment to potentially extend survival without compromising quality of life 1.Diagnosis
Pretreatment Workup: Comprehensive imaging (CT, MRI, PET) to identify and localize oligometastatic lesions 1.
Lesion Characteristics: Focus on size and number of metastatic sites, particularly relevant in lung oligometastases 1.Management
First-Line Treatment: Systemic therapy including targeted agents and immunotherapy, tailored to primary tumor type 1.
Adjunctive Treatment: Local radiotherapy regimens tailored to lesion localization and size, aiming to control oligometastatic disease 1.
Combination Therapy: Synergistic use of radiotherapy with systemic treatments to enhance outcomes 1.Special Populations
No Specific Guidance Provided: Abstracts do not cover special populations such as pregnancy, pediatrics, elderly, or comorbidities 1.Key Recommendations
Incorporate local radiotherapy for lung oligometastases in conjunction with systemic therapy to potentially prolong survival (Evidence: Moderate) 1.
Tailor radiotherapy regimens based on the size and location of metastatic lesions (Evidence: Expert opinion) 1.
Consider synergistic effects when combining radiotherapy with targeted therapies or immunotherapies (Evidence: Expert opinion) 1.References
1 Bourbonne V, Lévy A, Khalifa J, Antoni D, Blais E, Darréon J et al.. Radiotherapy in the management of lung oligometastases. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 2024. link