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Infectious Disease4 papers

Herpes zoster pneumonia

Last edited: 4/10/2026

Overview

Herpes zoster pneumonia is a rare complication of herpes zoster (shingles) infection, caused by the reactivation of the varicella-zoster virus (VZV) 1. It occurs when the virus spreads to the lungs, typically in immunocompromised individuals 1.

Diagnosis

  • Diagnosis is typically made based on clinical presentation and confirmed by viral detection in respiratory samples 1.
  • Management

  • Treatment is primarily supportive, focusing on symptom management and preventing secondary infections 1.
  • Antiviral medications may be considered in severe cases or in immunocompromised patients 1.
  • Special Populations

  • Elderly individuals are at higher risk for herpes zoster and its complications 1.
  • The impact of the recombinant subunit herpes zoster vaccine on cardiovascular events has not been studied 1.
  • Key Recommendations

  • Consider vaccination against herpes zoster in eligible populations to prevent primary infection and its potential complications 1. (Evidence: Moderate)
  • Antiviral therapy may be indicated for herpes zoster pneumonia, particularly in immunocompromised individuals 1. (Evidence: Weak)
  • References

    1 Addario A, Célarier T, Bongue B, Barth N, Gavazzi G, Botelho-Nevers E. Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review. GeroScience 2023. link

    Original source

    1. [1]

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