Overview
Intrahepatic cholangiocarcinoma (iCCA) is a primary malignancy of the bile ducts within the liver 1. It is a type of biliary tract cancer (BTC) that requires comprehensive evaluation and care 1.Diagnosis
Diagnosis involves evaluation and staging of the tumor 1.
Recommended tests include imaging and potentially biopsy for definitive diagnosis and staging 1.
Grading of the tumor is part of the diagnostic workup 1.Management
Treatment options for advanced BTCs, including iCCA, are discussed 1.
Adjuvant chemotherapy and chemoradiation are considered for BTCs 1.
Systemic treatment recommendations for advanced BTCs are provided 1.Key Recommendations
The NCCN Guidelines provide recommendations for the evaluation and comprehensive care of patients with intrahepatic cholangiocarcinoma 1. (Evidence: Expert opinion)
Adjuvant chemotherapy and chemoradiation are treatment options for biliary tract cancers 1. (Evidence: Expert opinion)
Systemic treatment recommendations are available for patients with advanced biliary tract cancers 1. (Evidence: Expert opinion)References
1 Benson AB, D'Angelica MI, Abrams T, Ahmed A, Akce M, Anaya DA et al.. Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. Journal of the National Comprehensive Cancer Network : JNCCN 2025. link