Overview
Metastatic carcinoma to the nasopharynx, also known as nasopharyngeal carcinoma (NPC), is a malignancy originating in the nasopharyngeal epithelium. Treatment strategies are often guided by the stage of the disease, with definitive-intent chemoradiotherapy being a key approach for locally advanced stages.Diagnosis
Diagnosis is typically based on clinical presentation, imaging (e.g., MRI, CT, PET-CT), and histopathological confirmation via biopsy 1.Management
Definitive-intent chemoradiotherapy is recommended for stage II-IVA nasopharyngeal carcinoma 1.
Treatment considerations include the sequence of chemotherapy and radiotherapy, as well as the use of concurrent, induction, or adjuvant chemotherapy 1.Key Recommendations
Chemotherapy in combination with radiotherapy is recommended for the definitive-intent treatment of stage II to IVA nasopharyngeal carcinoma 1. (Evidence: Strong)
Evidence-based recommendations address aspects of care related to chemotherapy in combination with RT for the definitive-intent treatment of stage II to IVA NPC, including radiotherapy, chemotherapy sequence, and concurrent, induction, and adjuvant chemotherapy options 1. (Evidence: Strong)References
1 Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH et al.. Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2021. link