Overview
Myelodysplastic neoplasms (MDS) are a heterogeneous group of distinct entities characterized by ineffective hematopoiesis 1. Recent classification systems further subcharacterize MDS into morphologically and genetically defined groups 1.Diagnosis
Accurate diagnosis and subclassification require a multistep, systemic, and multimodal approach 1.
Key diagnostic and subclassification frameworks include the 5th edition of the World Health Organization Classification of Haematolymphoid Tumours and the International Consensus Classification 1.Management
Management strategies are guided by the specific subtype of MDS 1.Key Recommendations
Accurate diagnosis and subclassification of MDS require a multistep, systemic, and multimodal approach 1. (Evidence: Expert opinion)
Contemporary classification systems, such as the 5th edition of the WHO Classification of Haematolymphoid Tumours and the International Consensus Classification, further subcharacterize MDS into morphologically and genetically defined groups 1. (Evidence: Expert opinion)References
1 Aakash F, Gisriel SD, Zeidan AM, Bennett JM, Bejar R, Bewersdorf JP et al.. Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes-Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS]). Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2024. link