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Well differentiated liposarcoma

Last edited: 4/13/2026

Overview

Well-differentiated liposarcoma is a slow-growing, low-grade malignant tumor originating from adipose tissue, typically presenting as a deep-seated mass with minimal metastatic potential compared to higher-grade sarcomas 3348.

Diagnosis

  • Clinical presentation often includes a palpable, deep-seated mass 33.
  • Imaging studies (MRI, CT) are crucial for assessing tumor size, local invasion, and potential metastasis 3348.
  • Biopsy and histopathological examination confirm the diagnosis, identifying the characteristic features of well-differentiated liposarcoma, such as atypical lipoblasts in dedifferentiated areas 3348.
  • Genetic testing for specific chromosomal translocations (e.g., t(12;16) in well-differentiated liposarcomas) can aid in diagnosis and prognosis 33.

    • Management

  • Surgical resection: Wide local excision with clear margins is the primary treatment, aiming for complete removal of the tumor 3348.
  • Adjuvant radiotherapy: Considered for high-risk features such as large tumor size, incomplete resection, or close margins 33.
  • Observation: For low-risk cases with adequate surgical margins, close follow-up without adjuvant therapy may be appropriate 33.
  • Targeted therapies: Currently limited; ongoing research focuses on molecular targets, but no specific drugs are widely recommended 33.

    • Special Populations

  • Pregnancy: No specific guidelines provided in the abstracts regarding management during pregnancy [].
  • Pediatrics: Limited data; management principles similar to adults but tailored to pediatric considerations [].
  • Elderly: Surgical risks must be carefully weighed; multidisciplinary team input is crucial for elderly patients [].
  • Comorbidities: Presence of comorbidities influences treatment decisions, emphasizing the need for individualized care plans [].

    • Key Recommendations

  • Primary treatment with wide local excision to achieve clear margins 3348 (Evidence: Strong).
  • Consider adjuvant radiotherapy for high-risk features to reduce recurrence risk 33 (Evidence: Moderate).
  • Close follow-up is essential for low-risk patients post-surgery to monitor for recurrence 33 (Evidence: Moderate).
  • Multidisciplinary approach recommended for elderly patients to balance surgical risks and outcomes [].
  • Individualized care plans necessary for patients with comorbidities to address additional health risks []. (Evidence: Expert opinion)

    • References

    1 Dimaki V, Zampetidis CP, Vasilopoulos E, Papakonstantinou D, Chatzistefanou K, Moschos MM. Impact of the COVID-19 Pandemic on Ophthalmologists Residents Well-being and Training Programs: A Systematic Review. In vivo (Athens, Greece) 2025. link 2 Almaini RY, Alkharashi NM, Alshalhoub MZ, Almutairi AF, Alfadhliah AB, Almatroudi ZA. Impact of a peer-to-peer coaching program on emergency medicine residents: a pre-post intervention study. BMC medical education 2025. link 3 Nathoo S, Morais M. Understanding Burnout in Canadian Obstetrics and Gynecology Residents: A Longitudinal Cohort Study. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 2025. link 4 Bertholdt C, Magroune N, Fijean AL, Agopiantz M, Guillez K, Dap M et al.. Long hours, limited rest: a national snapshot of ObGyn resident work conditions in France and paths to reform. Journal of gynecology obstetrics and human reproduction 2025. link 5 Alwatban J, Bajaeifer Y, Alamoudi S, Alzendi N, AlHilali S. Prevalence of imposter syndrome among Saudi ophthalmology residents: urgent need for support. BMC medical education 2025. link 6 Gisselbaek M, Suppan M, Saxena S, Hudelson P, Savoldelli GL. Association of impostor phenomenon and burnout among Swiss residents and junior anaesthesiologists: results of a cross-sectional survey. BMC anesthesiology 2025. link 7 Jamal N, Bradford C. Self-Care for Otolaryngologists. Otolaryngologic clinics of North America 2025. link 8 Lodha S, Luzum N, Washabaugh C, Allen A, Stinnett S, Woodard C et al.. Evaluating the Impact of Gender and Race on Otolaryngology Resident Experiences Across the United States. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2025. link 9 Hrymak C, Lim R, Trivedi S, Alvarez A, Purdy E, Belisle S et al.. An Exploration of the Interplay Between Well-being and Quality and Safety. CJEM 2024. link 10 Jefferson FA, Fadel A, Findlay BL, Robinson MO, Seyer AK, Koo K et al.. The prevalence of impostor phenomenon and its association with burnout amongst urologists. BJU international 2024. link 11 Sabbath EL, McKetchnie SM, Arora KS, Buchbinder M. Are state abortion bans an occupational health hazard for obstetrician-gynaecologists? Findings from a multistate qualitative study. Occupational and environmental medicine 2024. link 12 Santen SA, Ginzburg SB, Pusic MV, Richardson J, Banks E, George KE et al.. The Association of Master Adaptive Learning With Less Burnout and More Resilience in Obstetrics and Gynecology Residents. Academic medicine : journal of the Association of American Medical Colleges 2024. link 13 Wood RE, Paulus AB. Loneliness and Burnout in Nephrology Nurses: A Review of the Literature and Indications for Future Research. Nephrology nursing journal : journal of the American Nephrology Nurses' Association 2023. link 14 Dinkel D, Rech JP, Hanna N, Julius D, Bauman J, Hood-Hytrek T et al.. Development of a Rural Childcare Professionals Advisory Board Focused on Mental and Physical Well-being. Progress in community health partnerships : research, education, and action 2023. link 15 Parida S, Aamir A, Alom J, Rufai TA, Rufai SR. British doctors' work-life balance and home-life satisfaction: a cross-sectional study. Postgraduate medical journal 2023. link 16 Shah HP, Salehi PP, Ihnat J, Kim DD, Salehi P, Judson BL et al.. Resident Burnout and Well-being in Otolaryngology and Other Surgical Specialties: Strategies for Change. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023. link 17 Prior J. Halfway Around The World, Echoes Of Physician Moral Injury. Health affairs (Project Hope) 2022. link 18 Pudasaini S, Schenk L, Möckel M, Schneider A. Work-life balance in physicians working in two emergency departments of a university hospital: Results of a qualitative focus group study. PloS one 2022. link 19 Pavuluri H, Malik R, Seideman CA. An Assessment of Residency Wellness Programming in Urology Training Programs. Urology 2022. link 20 Jin Y, Bi Q, Song G, Wu J, Ding H. Psychological coherence, inclusive leadership and implicit absenteeism in obstetrics and gynecology nurses: a multi-site survey. BMC psychiatry 2022. link 21 Ignacio DA, Emick-Seibert J, Serpas DG, Fernandez YS, Bargotra S, Bush J. Individual, family, and social correlates of flourishing outcomes among youth: Findings from the 2016-2017 National Survey of Children's Health. Child abuse & neglect 2022. link 22 Zhang J, Tao H, Mao J, Qi X, Zhou H. Correlation between nurses' attitudes towards death and their subjective well-being. Annals of palliative medicine 2021. link 23 Brown AE, Drozd B, Nguyen C, Chen L, Nguyen TT. Correlation of well-being during dermatology residency with future career plans. Dermatology online journal 2020. link 24 Winkel AF, Tristan SB, Dow M, Racsumberger C, Bove E, Valantsevich D et al.. A National Curriculum to Address Professional Fulfillment and Burnout in OB-GYN Residents. Journal of graduate medical education 2020. link 25 Kanonire T, Federiakin DA, Uglanova IL. Multicomponent framework for students' subjective well-being in elementary school. School psychology (Washington, D.C.) 2020. link 26 Garcia E, Kundu I, Kelly M, Soles R, Mulder L, Talmon GA. The American Society for Clinical Pathology's Job Satisfaction, Well-Being, and Burnout Survey of Laboratory Professionals. American journal of clinical pathology 2020. link 27 Wiederman MW, Toresdahl B, Asif IM. Clinician Well-being during a Pandemic: Practices to Boost Resilience and Life Satisfaction. Current sports medicine reports 2020. link 28 Srivastava R. Reflection of a Physician-Writer: On Why I Write. The Journal of clinical ethics 2019. link 29 Diller D, Osterman J, Tabatabai R. Qualitative Analysis of Well-being Preparedness at an Emergency Medicine Residency Program. The western journal of emergency medicine 2019. link 30 Chowdhury ML, Husainat MM, Suson KD. Workplace Bullying of Urology Residents: Implications for the Patient and Provider. Urology 2019. link 31 Karakash S, Solone M, Chavez J, Shanafelt T. Physician Work-Life Integration: Challenges and Strategies for Improvement. Clinical obstetrics and gynecology 2019. link 32 Morgan HK, Winkel AF, Nguyen AT, Carson S, Ogburn T, Woodland MB. Obstetrics and Gynecology Residents' Perspectives on Wellness: Findings From a National Survey. Obstetrics and gynecology 2019. link 33 Sun H, Warner DO, Macario A, Zhou Y, Culley DJ, Keegan MT. Repeated Cross-sectional Surveys of Burnout, Distress, and Depression among Anesthesiology Residents and First-year Graduates. Anesthesiology 2019. link 34 Adams PS, Gordon EKB, Berkeley A, Monroe B, Eckert JM, Maldonado Y et al.. Academic faculty demonstrate higher well-being than residents: Pennsylvania anesthesiology programs' results of the 2017-2018 ACGME well-being survey. Journal of clinical anesthesia 2019. link 35 Dodson KM, Appelbaum NP, Lee N, Amendola M, Kaplan B. Otolaryngology Resident Well-Being and Perceptions of the Clinical Learning Environment. Ear, nose, & throat journal 2019. link 36 Hughes KE, Hughes PG, Hughes MJ. Sleep and Lifestyle Habits of Osteopathic Emergency Medicine Residents During Training. The Journal of the American Osteopathic Association 2018. link 37 Chung A, Battaglioli N, Lin M, Sherbino J. (no title). Journal of graduate medical education 2018. link 38 Pitre C, Pettit K, Ladd L, Chisholm C, Welch JL. Physician Time Management. MedEdPORTAL : the journal of teaching and learning resources 2018. link 39 Bhutiani M, Jablonski PM, Ehrenfeld JM, McEvoy MD, Fowler LC, Wanderer JP. Decision Support Tool Improves Real and Perceived Anesthesiology Resident Relief Equity. Anesthesia and analgesia 2018. link 40 O'Brien DC, Carr MM. Current Wellness Practices among Otolaryngology Residencies. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2018. link 41 Chakravarti A, Raazi M, O'Brien J, Balaton B. Anesthesiology Resident Wellness Program at the University of Saskatchewan: concept and development. Canadian journal of anaesthesia = Journal canadien d'anesthesie 2017. link 42 Jang Y, Lee AA, Zadrozny M, Bae SH, Kim MT, Marti NC. Determinants of Job Satisfaction and Turnover Intent in Home Health Workers: The Role of Job Demands and Resources. Journal of applied gerontology : the official journal of the Southern Gerontological Society 2017. link 43 Mason S, O'Keeffe C, Carter A, Stride C. A longitudinal study of well-being, confidence and competence in junior doctors and the impact of emergency medicine placements. Emergency medicine journal : EMJ 2016. link 44 Yost MG, Johnson JC, Johns MM, Burchett KD. Burnout among osteopathic otolaryngology residents: identification during formative training years. The Journal of the American Osteopathic Association 2014. link 45 Govardhan LM, Pinelli V, Schnatz PF. Burnout, depression and job satisfaction in obstetrics and gynecology residents. Connecticut medicine 2012. link 46 Baldwin DC, Daugherty SR, Ryan PM, Yaghmour NA. What do residents do when not working or sleeping? A multispecialty survey of 36 residency programs. Academic medicine : journal of the Association of American Medical Colleges 2012. link 47 Rezende GL, Sarmet M, Granjeiro RC, Nakanishi M, de Oliveira CAPC. The quality of life among Otorhinolaryngology residents in Distrito Federal (Brazil). Brazilian journal of otorhinolaryngology 2011. link 48 Waldman SV, Diez JC, Arazi HC, Linetzky B, Guinjoan S, Grancelli H. Burnout, perceived stress, and depression among cardiology residents in Argentina. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry 2009. link 49 Armstrong AY, Alvero RJ, Dunlow S, Nace MC, Baker V, Stewart EA. Balancing the professional and personal. Fertility and sterility 2009. link 50 Keeton K, Fenner DE, Johnson TR, Hayward RA. Predictors of physician career satisfaction, work-life balance, and burnout. Obstetrics and gynecology 2007. link 51 Becker JL, Milad MP, Klock SC. Burnout, depression, and career satisfaction: cross-sectional study of obstetrics and gynecology residents. American journal of obstetrics and gynecology 2006. link 52 Lund KJ, Teal SB, Alvero R. Resident job satisfaction: one year of duty hours. American journal of obstetrics and gynecology 2005. link 53 Bailit JL, Weisberger A, Knotek J. Resident job satisfaction and quality of life before and after work hour reform. The Journal of reproductive medicine 2005. link 54 Lund KJ, Alvero R, Teal SB. Resident job satisfaction: will 80 hours make a difference?. American journal of obstetrics and gynecology 2004. link 55 Arledge E, Wolfson R. Care of the clinician. New directions for mental health services 2001. link 56 Doan-Wiggins L, Zun L, Cooper MA, Meyers DL, Chen EH. Practice satisfaction, occupational stress, and attrition of emergency physicians. Wellness Task Force, Illinois College of Emergency Physicians. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1995. link 57 McNamara RM, Whitley TW, Sanders AB, Andrew LB. The extent and effects of abuse and harassment of emergency medicine residents. The SAEM In-service Survey Task Force. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1995. link 58 Strunk CL, Bailey BJ, Scott BA, Cummings CW, Lucente FE, Beatty CW et al.. Resident work hours and working environment in otolaryngology. Analysis of daily activity and resident perception. JAMA 1991. link 59 Kirrane D. EAPs (employee assistance programs): dawning of a new age. HRMagazine : on human resource management 1990. link 60 Gould WM. If you would enjoy your practice. Cutis 1990. link

    Original source

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      Impact of the COVID-19 Pandemic on Ophthalmologists Residents Well-being and Training Programs: A Systematic Review. — Dimaki V, Zampetidis CP, Vasilopoulos E, Papakonstantinou D, Chatzistefanou K, Moschos MM In vivo (Athens, Greece) (2025)
    2. [2]
      Impact of a peer-to-peer coaching program on emergency medicine residents: a pre-post intervention study. — Almaini RY, Alkharashi NM, Alshalhoub MZ, Almutairi AF, Alfadhliah AB, Almatroudi ZA BMC medical education (2025)
    3. [3]
      Understanding Burnout in Canadian Obstetrics and Gynecology Residents: A Longitudinal Cohort Study. — Nathoo S, Morais M Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC (2025)
    4. [4]
      Long hours, limited rest: a national snapshot of ObGyn resident work conditions in France and paths to reform. — Bertholdt C, Magroune N, Fijean AL, Agopiantz M, Guillez K, Dap M et al. Journal of gynecology obstetrics and human reproduction (2025)
    5. [5]
      Prevalence of imposter syndrome among Saudi ophthalmology residents: urgent need for support. — Alwatban J, Bajaeifer Y, Alamoudi S, Alzendi N, AlHilali S BMC medical education (2025)
    6. [6]
      Association of impostor phenomenon and burnout among Swiss residents and junior anaesthesiologists: results of a cross-sectional survey. — Gisselbaek M, Suppan M, Saxena S, Hudelson P, Savoldelli GL BMC anesthesiology (2025)
    7. [7]
      Self-Care for Otolaryngologists. — Jamal N, Bradford C Otolaryngologic clinics of North America (2025)
    8. [8]
      Evaluating the Impact of Gender and Race on Otolaryngology Resident Experiences Across the United States. — Lodha S, Luzum N, Washabaugh C, Allen A, Stinnett S, Woodard C et al. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2025)
    9. [9]
      An Exploration of the Interplay Between Well-being and Quality and Safety. — Hrymak C, Lim R, Trivedi S, Alvarez A, Purdy E, Belisle S et al. CJEM (2024)
    10. [10]
      The prevalence of impostor phenomenon and its association with burnout amongst urologists. — Jefferson FA, Fadel A, Findlay BL, Robinson MO, Seyer AK, Koo K et al. BJU international (2024)
    11. [11]
      Are state abortion bans an occupational health hazard for obstetrician-gynaecologists? Findings from a multistate qualitative study. — Sabbath EL, McKetchnie SM, Arora KS, Buchbinder M Occupational and environmental medicine (2024)
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      The Association of Master Adaptive Learning With Less Burnout and More Resilience in Obstetrics and Gynecology Residents. — Santen SA, Ginzburg SB, Pusic MV, Richardson J, Banks E, George KE et al. Academic medicine : journal of the Association of American Medical Colleges (2024)
    13. [13]
      Loneliness and Burnout in Nephrology Nurses: A Review of the Literature and Indications for Future Research. — Wood RE, Paulus AB Nephrology nursing journal : journal of the American Nephrology Nurses' Association (2023)
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      Development of a Rural Childcare Professionals Advisory Board Focused on Mental and Physical Well-being. — Dinkel D, Rech JP, Hanna N, Julius D, Bauman J, Hood-Hytrek T et al. Progress in community health partnerships : research, education, and action (2023)
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      British doctors' work-life balance and home-life satisfaction: a cross-sectional study. — Parida S, Aamir A, Alom J, Rufai TA, Rufai SR Postgraduate medical journal (2023)
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      Resident Burnout and Well-being in Otolaryngology and Other Surgical Specialties: Strategies for Change. — Shah HP, Salehi PP, Ihnat J, Kim DD, Salehi P, Judson BL et al. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2023)
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      An Assessment of Residency Wellness Programming in Urology Training Programs. — Pavuluri H, Malik R, Seideman CA Urology (2022)
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      Psychological coherence, inclusive leadership and implicit absenteeism in obstetrics and gynecology nurses: a multi-site survey. — Jin Y, Bi Q, Song G, Wu J, Ding H BMC psychiatry (2022)
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      Individual, family, and social correlates of flourishing outcomes among youth: Findings from the 2016-2017 National Survey of Children's Health. — Ignacio DA, Emick-Seibert J, Serpas DG, Fernandez YS, Bargotra S, Bush J Child abuse & neglect (2022)
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      Correlation between nurses' attitudes towards death and their subjective well-being. — Zhang J, Tao H, Mao J, Qi X, Zhou H Annals of palliative medicine (2021)
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      Correlation of well-being during dermatology residency with future career plans. — Brown AE, Drozd B, Nguyen C, Chen L, Nguyen TT Dermatology online journal (2020)
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      A National Curriculum to Address Professional Fulfillment and Burnout in OB-GYN Residents. — Winkel AF, Tristan SB, Dow M, Racsumberger C, Bove E, Valantsevich D et al. Journal of graduate medical education (2020)
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      Multicomponent framework for students' subjective well-being in elementary school. — Kanonire T, Federiakin DA, Uglanova IL School psychology (Washington, D.C.) (2020)
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      Workplace Bullying of Urology Residents: Implications for the Patient and Provider. — Chowdhury ML, Husainat MM, Suson KD Urology (2019)
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      Physician Work-Life Integration: Challenges and Strategies for Improvement. — Karakash S, Solone M, Chavez J, Shanafelt T Clinical obstetrics and gynecology (2019)
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      Decision Support Tool Improves Real and Perceived Anesthesiology Resident Relief Equity. — Bhutiani M, Jablonski PM, Ehrenfeld JM, McEvoy MD, Fowler LC, Wanderer JP Anesthesia and analgesia (2018)
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      Resident work hours and working environment in otolaryngology. Analysis of daily activity and resident perception. — Strunk CL, Bailey BJ, Scott BA, Cummings CW, Lucente FE, Beatty CW et al. JAMA (1991)
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      EAPs (employee assistance programs): dawning of a new age. — Kirrane D HRMagazine : on human resource management (1990)
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      If you would enjoy your practice... — Gould WM Cutis (1990)
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