Overview
Papillary eccrine adenoma is a rare, benign sweat gland tumor characterized by dilated ducts filled with eosinophilic secretion and intraluminal papillations 1. It was first described by Rulon and Helwig in 1977, with subsequent case reports reinforcing its benign nature 1.Diagnosis
Morphological Features: Dilated ducts with eosinophilic secretion and intraluminal papillations 1.
Immunohistochemical Markers: Positive for cytokeratins, S100 protein, and carcinoembryonic antigen 1.
Histopathological Examination: Essential for definitive diagnosis 1.Management
Surgical Excision: Recommended for definitive treatment and to rule out malignancy 1.
Follow-Up: Post-surgical monitoring to ensure no recurrence 1.Special Populations
No Specific Guidelines: Limited data on management in pregnancy, pediatrics, elderly, or with comorbidities 1.Key Recommendations
Confirm diagnosis through histopathological examination with immunohistochemical staining for cytokeratins, S100 protein, and carcinoembryonic antigen (Evidence: Moderate) 1.
Perform complete surgical excision as the primary treatment approach (Evidence: Expert opinion) 1.
Implement regular follow-up post-surgery to monitor for recurrence (Evidence: Expert opinion) 1.References
1 Urmacher C, Lieberman PH. Papillary eccrine adenoma. Light-microscopic, histochemical, and immunohistochemical studies. The American Journal of dermatopathology 1987. link