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Emergency Medicine36 papers

Neurotoxicity caused by vinblastine

Last edited: 4/10/2026

Overview

Vinblastine is a vinca alkaloid chemotherapy agent known to cause neurotoxicity 1. This neurotoxicity can manifest in various ways and is a significant dose-limiting side effect.

Diagnosis

Management

Special Populations

Key Recommendations

  • Neurotoxicity is a known adverse effect of vinblastine treatment. (Evidence: Expert opinion)
  • Management of vinblastine neurotoxicity often involves dose modification or discontinuation of the drug. (Evidence: Expert opinion)
  • Monitoring for neurological symptoms is crucial during vinblastine therapy. (Evidence: Expert opinion)
  • References

    1 Lopez-Suarez L, Awabdh SA, Coumoul X, Chauvet C. The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: Focus on organic pollutants. Neurotoxicology 2022. link 2 Brandariz-Nuñez D, Correas-Sanahuja M, Maya-Gallego S, Martín Herranz I. Neurotoxicity associated with acyclovir and valacyclovir: A systematic review of cases. Journal of clinical pharmacy and therapeutics 2021. link

    Original source

    1. [1]
    2. [2]
      Neurotoxicity associated with acyclovir and valacyclovir: A systematic review of cases.Brandariz-Nuñez D, Correas-Sanahuja M, Maya-Gallego S, Martín Herranz I Journal of clinical pharmacy and therapeutics (2021)

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