Overview
Stable tachyarrhythmias are abnormal heart rhythms characterized by a rapid heart rate that persists over time. These rhythms arise from complex electrical activity in the heart, involving the coordinated function of numerous ion channels 1.Diagnosis
Management
Co-expression of calcium (CACNA1C) and hERG potassium (KCNH2) channels may reduce the incidence of proarrhythmic events 1.
In silico modeling suggests that co-expression of CACNA1C and KCNH2 can limit action potential duration variability and reduce susceptibility to early afterdepolarizations 1.Special Populations
Key Recommendations
Co-expression of CACNA1C and KCNH2 channels is associated with reduced proarrhythmia 1. (Evidence: Moderate)
Co-expression of CACNA1C and KCNH2 channels may limit action potential duration variability 1. (Evidence: Moderate)
Co-expression of CACNA1C and KCNH2 channels may reduce susceptibility to early afterdepolarizations 1. (Evidence: Moderate)References
1 Ballouz S, Mangala MM, Perry MD, Heitmann S, Gillis JA, Hill AP et al.. Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events. Cardiovascular research 2021. link