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Allergy & Immunology245 papers

ALPI-related inflammatory bowel disease

Last edited: 4/15/2026

Overview

ALPI (alkaline phosphatase isoenzyme)-related inflammatory bowel disease is not directly addressed in the provided abstracts. The abstracts focus on the biochemical and purification aspects of alkaline phosphatase rather than its clinical implications in inflammatory bowel disease.

Diagnosis

  • No specific diagnostic criteria or tests for ALPI-related inflammatory bowel disease are mentioned in the abstracts 123.

    • Management

  • No first-line or adjunctive treatments for ALPI-related inflammatory bowel disease are detailed in the provided abstracts 123.

    • Special Populations

  • No information regarding pregnancy, pediatrics, elderly, or comorbidities in relation to ALPI-related inflammatory bowel disease is provided 123.

    • Key Recommendations

  • Utilize advanced biochemical techniques for isolating and purifying alkaline phosphatase for research purposes in understanding potential disease mechanisms (Evidence: Expert opinion) 123
  • Further clinical studies are required to establish diagnostic and therapeutic approaches for ALPI-related inflammatory bowel disease (Evidence: Expert opinion) 123
  • Investigate the secretion pathways of alkaline phosphatase in pathogenic contexts to uncover potential therapeutic targets (Evidence: Expert opinion) 3

    • References

    1 Tuan RS, Fitzpatrick DF. Alkaline phosphatase conjugated protein A as a sensitive reagent to immunoscreen an expression cDNA plasmid library: isolation of cDNA to the calcium-binding protein of the chick embryonic chorioallantoic membrane. Analytical biochemistry 1986. link90350-7) 2 Oida S, Sone M, Sasaki S. Purification of swine kidney alkaline phosphatase by immunoaffinity chromatography. Analytical biochemistry 1984. link90141-6) 3 Schlesinger MJ. Secretion of alkaline phosphatase subunits by spheroplasts of Escherichia coli. Journal of bacteriology 1968. link

    Original source

    1. [1]
      Alkaline phosphatase conjugated protein A as a sensitive reagent to immunoscreen an expression cDNA plasmid library: isolation of cDNA to the calcium-binding protein of the chick embryonic chorioallantoic membrane. — Tuan RS, Fitzpatrick DF Analytical biochemistry (1986)
    2. [2]
      Purification of swine kidney alkaline phosphatase by immunoaffinity chromatography. — Oida S, Sone M, Sasaki S Analytical biochemistry (1984)
    3. [3]
      Secretion of alkaline phosphatase subunits by spheroplasts of Escherichia coli. — Schlesinger MJ Journal of bacteriology (1968)
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