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Hematology33 papers

Malignant solid pseudopapillary neoplasm

Last edited: 4/15/2026

Overview

Solid pseudopapillary neoplasm (SPN) is a rare, typically benign neoplasm predominantly found in the pancreas, with low malignant potential but capable of exhibiting aggressive behavior in rare cases 2.

Diagnosis

  • Imaging studies (ultrasound, CT) essential for initial detection and characterization 2.
  • Biopsy may be required for definitive diagnosis, though endoscopic techniques can aid in minimally invasive assessment 2.
  • No specific biochemical markers mentioned for routine diagnosis 1.
  • Management

  • Surgical resection (distal pancreatectomy, splenectomy if necessary) is the primary treatment modality 2.
  • Endoscopic techniques, such as linear stapler use, can facilitate safer surgical procedures in complex cases 2.
  • Management of concurrent conditions like regional portal hypertension requires tailored surgical approaches 2.
  • Special Populations

  • No specific guidance provided for pregnancy, pediatrics, or elderly populations in the given abstracts 2.
  • Comorbidities like regional portal hypertension may influence surgical planning but are not extensively covered 2.
  • Key Recommendations

  • Surgical resection is recommended for definitive treatment of solid pseudopapillary neoplasms 2 (Evidence: Strong).
  • Consider endoscopic techniques to enhance safety during surgical interventions, particularly in complex anatomical scenarios 2 (Evidence: Moderate).
  • Tailor surgical approaches based on concurrent conditions, such as regional portal hypertension, to optimize patient outcomes 2 (Evidence: Expert opinion).
  • References

    1 Winther-Larsen A, Sandfeld-Paulsen B, Hvas AM. Hyperfibrinolysis in Patients with Solid Malignant Neoplasms: A Systematic Review. Seminars in thrombosis and hemostasis 2021. link 2 Yang JR, Xiao R, Zhou J, Wang ZF, Ren JJ. Endoscopic linear stapler-assisted resection of a giant solid pseudopapillary pancreatic tumor with concurrent regional portal hypertension: a case report. The Journal of international medical research 2018. link

    Original source

    1. [1]
      Hyperfibrinolysis in Patients with Solid Malignant Neoplasms: A Systematic Review.Winther-Larsen A, Sandfeld-Paulsen B, Hvas AM Seminars in thrombosis and hemostasis (2021)
    2. [2]

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