Overview
Borna disease virus 1 (BoDV-1) causes a severe, predominantly fatal encephalitis in humans 1. Borna disease has been recognized in horses and sheep for over two centuries 1.Diagnosis
The exact propagation mechanisms, entry portal, and viral spread within the central nervous system (CNS) are not entirely clear in humans 1.
Histopathological changes and immunological responses remain largely unexplored in humans 1.Management
No specific management strategies are mentioned in the provided abstract.Special Populations
No specific information regarding special populations is available in the provided abstract.Key Recommendations
Future research should focus on identifying potential entry sites and viral spread in dead-end hosts to clarify pathogenesis and lesion distribution in the CNS in humans 1. (Evidence: Expert opinion)
Further investigation is needed to understand transmission, pathogenesis, histopathological changes, and immunology of BoDV-1 in humans 1. (Evidence: Expert opinion)References
1 Jungbäck N, Vollmuth Y, Mögele T, Grochowski P, Schlegel J, Schaller T et al.. Neuropathology, pathomechanism, and transmission in zoonotic Borna disease virus 1 infection: a systematic review. The Lancet. Infectious diseases 2025. link00675-3)