Overview
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by airflow limitation, often caused by long-term exposure to harmful particles or gases, primarily affecting individuals with a history of smoking. It significantly impacts respiratory function and is associated with substantial morbidity and mortality 127.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 1918 indexed papers.
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Tailored Exercise Prescription for People with COPD and Clinically Relevant Comorbidities: A Consensus Statement of the EXPERT Working Group and Experts in Pulmonary Rehabilitation. Sports medicine (Auckland, N.Z.) 2026. link 24 Biondi F, Ghelardoni S, Morrone D, De Caterina R, Madonna R. Exercise pulmonary hypertension in chronic thromboembolic pulmonary disease without resting pulmonary hypertension: A systematic review and meta-analysis. Vascular pharmacology 2026. link 25 Yang Y, Liu Q, Filippidis FT, Lu P, Guo Y. Association and biological pathways between lifetime occupational exposure to workplace hazards and incident chronic obstructive pulmonary disease and cardiovascular disease in middle-aged and older adults. Journal of hazardous materials 2026. link 26 Shomura T, Wada Y, Goto N, Suzuki Y, Kitaguchi Y, Ushiki A et al.. Impact of bendopnea on indicators of pulmonary hypertension, health-related quality of life, and pulmonary function in patients with chronic obstructive pulmonary disease. Respiratory investigation 2026. link 27 de Simón Gutiérrez R, Alcázar Navarrete B, Alonso Ortiz MB, Delgado Jiménez JF, Gómez Doblas JJ, Hurtado García R et al.. Integrated care for COPD and cardiovascular comorbidities: A multidisciplinary approach for the cardiopulmonary patient. Semergen 2026. link 28 de-Torres JP, Casanova C, Zagaceta J, Marín JM, Cabrera C, Ezponda A et al.. Cardiovascular Events in COPD: Complementary Role of Cardiac Risk and Coronary Artery Calcium Scores. Chest 2026. link 29 Wu Z, Wang D, Tang C. Comorbid management of chronic obstructive pulmonary disease and heart failure. Respiratory medicine 2026. link 30 Khan SA, Parikh T, Rao A, Agrawal A, Parikh A, Kazzaz F et al.. In-hospital Mortality Patterns and Readmissions in Patients With Chronic Obstructive Pulmonary Disease: An Analysis of the Role of Pulmonary Hypertension. COPD 2026. link 31 Wills W, Reyes P, Amon A, Lugo LD, Bizanti A, Bugajski A. Cardiovascular Disease as a Moderator Between Airflow Limitation and Health-Related Quality of Life Among Patients With Chronic Obstructive Pulmonary Disease. The Journal of cardiovascular nursing 2026. link 32 Kaşkal M, Bucci T, Wat D, Nazareth D, Lip GYH, Frost F. Outcomes of beta-blocker use in people living with chronic obstructive pulmonary disease and a co-existent beta-blocker indicated cardiovascular disease. Insights from a global federated network. BMC pulmonary medicine 2026. link 33 Martín de Miguel I, Jiménez López-Guarch C, Segura de La Cal T, Huertas Nieto S, Sarnago Cebada F, Velázquez Martín M et al.. Chronic Thromboembolic Pulmonary Disease With Exercise Pulmonary Hypertension: A Noninvasive Model to Predict Exercise Hemodynamics. 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International journal of chronic obstructive pulmonary disease 2026. link 42 Xu S, Zhou J, Xu X. Declining Prevalence and Disability Burden of Chronic Obstructive Pulmonary Disease Associated With Heart Failure. Geriatrics & gerontology international 2026. link 43 Singh D, Stockley R, Anzueto A, Agusti A, Bourbeau J, Celli BR et al.. GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD. The European respiratory journal 2025. link 44 Pitre T, Lupas D, Mah J, Stanbrook M, Blazer A, Zeraatkar D et al.. Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. COPD 2025. link 45 Xu Y, Zhang L, Chen C, Zou M, Wang K, Liu X et al.. Investigation of the efficacy and potential pharmacological mechanism of Yupingfeng in treating chronic obstructive pulmonary disease: A meta-analysis and in silico study. Journal of ethnopharmacology 2025. link 46 Yappalparvi A, Balaraman AK, Padmapriya G, Gaidhane S, Kaur I, Lal M et al.. Safety and efficacy of ensifentrine in COPD: A systemic review and meta-analysis. Respiratory medicine 2025. link 47 Fandos Vázquez P, Díez-Manglano J. Thyroid hormones in people with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Respiratory medicine 2025. link 48 Zhuang M, Hassan II, W Ahmad WMA, Abdul Kadir A, Liu X, Li F et al.. Effectiveness of Digital Health Interventions for Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis. Journal of medical Internet research 2025. link 49 Wu K, Lu L, Chen Y, Peng J, Wu X, Tang G et al.. Associations of anxiety and depression with prognosis in chronic obstructive pulmonary disease: A systematic review and meta-analysis. Pulmonology 2025. link 50 Song C, Hao X, Critselis E, Panagiotakos D. The impact of electronic cigarette use on chronic obstructive pulmonary disease: A systematic review and meta-analysis. Respiratory medicine 2025. link 51 Dou Y, Zhang L, Wang Y, Xu X, Wu B. Effectiveness of nursing care intervention on the management of patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis of randomized controlled trials. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2025. link 52 Hernandez P, Bossé Y, Bush P, Chapman KR, Maltais F, Penz ED et al.. Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Meta-Analysis and Clinical Practice Guideline. Chest 2025. link 53 Li Y, Li J, Yang H, Zhang Y. Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials. BMC pulmonary medicine 2025. link 54 Chen Y, Zhang Y, Long X, Tu H, Chen J. Effectiveness of Virtual Reality-Complemented Pulmonary Rehabilitation on Lung Function, Exercise Capacity, Dyspnea, and Health Status in Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis. Journal of medical Internet research 2025. link 55 Ding K, Song F, Sun W, Sun M, Xia R. Impact of exercise training on cognitive function in patients with COPD: a systematic review and meta-analysis of randomised controlled trials. European respiratory review : an official journal of the European Respiratory Society 2025. link 56 Huang Y, Wang J, Chen S, Dai Z, Chen X, Li X et al.. Red cell distribution width related to the severity of the disease in patients with AECOPD. Biomarkers in medicine 2025. link 57 Zeng Y, He T, Ma X, Guo Q, Zhang J. Comparative Efficacy of Nutritional Supplements in Modulating Lung Function and Exercise Capacity in COPD Patients: A Network Meta-Analysis. International journal of chronic obstructive pulmonary disease 2025. link 58 Kwok WC, Tsui CK, Leung SHI, Ngai SM, Lam DCL, Ip MSM et al.. Dose of Inhaled Corticosteroid in Chronic Obstructive Pulmonary Disease and Risks of Osteoporosis or Fracture-A Systematic Review and Meta-Analysis. The clinical respiratory journal 2025. link 59 Malvi A, Khatib MN, Ganesan S, Kaur M, Srivastava M, Barwal A et al.. Assessing the impact of electronic nicotine delivery systems on chronic obstructive pulmonary disease: A systematic review and meta-analysis. Respiratory medicine 2025. link 60 Zhang X, Xue J, Chang Y, Zhang R, Zhao J, Li X et al.. Non-pharmacological interventions for fatigue in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis. Respiratory medicine 2025. link 61 Li X, Wang S, Ma X, Tang Y. Prevalence and the Mutual Relationship Between Chronic Obstructive Pulmonary Disease and Arbovirus: A Comprehensive Systematic Review and Meta-Analysis of Current Evidence. Reviews in medical virology 2025. link 62 Qiao P, Sheng P, Liu H, Liang H. Chronic Obstructive Pulmonary Disease and Lung Cancer: A Meta-Analysis of Risk Association. International journal of chronic obstructive pulmonary disease 2025. link 63 Alenezy N, Gu Y, Saleh R, Sheriff L, Unger M. Pulmonology: What You May Have Missed in 2024. Annals of internal medicine 2025. link 64 O'Connor S. COPD diagnosed using a multidimensional algorithm was associated with some adverse clinical outcomes over 10 y. Annals of internal medicine 2025. link 65 Patrucco F, Fantin A, Di Marco Berardino A, Majori M, Piro R, Pinelli V et al.. Results of AIPO Italian survey on sustainability in Interventional Pulmonology. Panminerva medica 2025. link 66 Josan E, Pastis N, Peng J, Ma J, Mahmood K, Danckers M et al.. A Survey of Program Directors on Procedural Competence and Volume in the US Pulmonary and Critical Care Fellowships. Journal of bronchology & interventional pulmonology 2025. link 67 Alwakeel M, Patrawalla P, Carlin B, Addrizzo-Harris D, Mastronarde J, Reitzner J et al.. Impact of COVID-19 on Pulmonary Critical Care Fellows In-Training Exam Performance: A National Study. Chest 2025. link 68 Hu AW, Beckman TJ, LeMahieu AM, Keetley HM, Adamson R, Patel HH et al.. Grit and resilience among pulmonary and critical care physicians: A multi-institutional study. The American journal of the medical sciences 2025. link 69 Seam N, Green J, Price DW. Strengthening Continuing Professional Development through Active Collaboration. ATS scholar 2025. link 70 Hauschildt KE, Kumar AJ, Viglianti EM, Vranas KC, Bernstein T, Moroz L et al.. US Physicians' Perceived Impacts of Abortion Bans in Pulmonary and Critical Care Medicine. Chest 2025. link 71 Kuperstein H, Gada K, Alam W, Ahmad S. 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Sclerotherapy embolism: a novel etiology for chronic thromboembolic pulmonary disease. BMC pulmonary medicine 2025. link 76 Brown TM, Zhang Y, Bauldoff G, Garvey C, Howard G. The American Association of Cardiovascular and Pulmonary Rehabilitation National Pulmonary Rehabilitation Registry: Design and Participant Characteristics. Journal of cardiopulmonary rehabilitation and prevention 2025. link 77 Saja MF, Younis AS, Alzahrani LA, Alkhlassi IN, Aldakhil LS, Albayyat RM et al.. The Association Between Medication Adherence and Health-Related Quality of Life in Patients with COPD: A Cross-Sectional Study. International journal of chronic obstructive pulmonary disease 2025. link 78 Abdelaziz A, Gaber CE, Gupta P, Lee TA. High Throughput Pharmacovigilance Screening for Roflumilast Adverse Effects in Real-World Settings: A Sequence Symmetry Analysis. Basic & clinical pharmacology & toxicology 2025. link 79 Xu R, Peng H, Shu C, Liu M, Gao P. Real-world safety profile of roflumilast: a pharmacovigilance analysis using FDA adverse event reporting system and Canada vigilance database. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2025. link 80 Rui Y, Xin T, Chen Y, Xiang B, Chen C, Zhang L et al.. Adverse drug events associated with tiotropium: a real-world pharmacovigilance study of FDA adverse event reporting system database. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2025. link 81 Wang YD, Wang YT, Chen HH, Bao JK, Chen SM, Chen DX. Pharmacovigilance Study on Adverse Events of Nicotine Replacement Therapy, Bupropion, and Varenicline in Patients with Chronic Obstructive Pulmonary Disease. International journal of chronic obstructive pulmonary disease 2025. link 82 Shen Q, Yang S, Wang S. Pharmacovigilance of five commonly used antibiotics in acute exacerbations of COPD (AECOPD): Analysis of the FDA adverse event reporting system database. Pulmonary pharmacology & therapeutics 2025. link 83 Baldan GA, De Maria M, Luciani M, Matarese M, Vellone E, Ausili D. Self-Care of Older Patients Affected by at Least Two Chronic Conditions Between Heart Failure, Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: A Comparative Study. Journal of clinical nursing 2025. link 84 Díez-Manglano J, Díaz-Peromingo JA, Boixeda-Viu R. Circadian pattern of blood pressure in patients with stable COPD. Revista clinica espanola 2025. link 85 Farkouh C, Chaouat A, Guillaumot A, Baptista BR, Chabot F, Valentin S. Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Impact of lung hyperinflation on the response to pulmonary hypertension treatment. Respiratory medicine and research 2025. link 86 Mahajan AK, Collar N, Muldowney F, Gorka P, Duong DK, Patel PP et al.. Echocardiography Findings for Pulmonary Hypertension During Workup for Bronchoscopic Lung Volume Reduction. Journal of bronchology & interventional pulmonology 2025. link 87 Aliyar AA, Eldar AS, Sadig SA, Mubariz GT, Adil MN, Aydın AS. Advances in the Study of Bronchial and Vascular Architecture of Lungs in the Rat's Model: from Morphogenesis to Disease Modelling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2025. link 88 Sun J, Wang W, Yu A, Zhou L, Hua M, Chen Y et al.. Pulmonary Hemodynamic Parameters Derived from 4D Flow MR Imaging Can Provide Sensitive Markers for Chronic Obstructive Pulmonary Disease (COPD) Patients with Right Ventricular Dysfunction. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2025. link 89 Zeng J, Feng J, Luo Y, Wei H, Ge H, Liu H et al.. 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Impact of Frailty on Major Adverse Cardiovascular Events in Chronic Obstructive Pulmonary Disease. International journal of chronic obstructive pulmonary disease 2025. link 98 Pirera E, Di Raimondo D, D'Anna L, Tuttolomondo A. Risk trajectory of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. European journal of internal medicine 2025. link 99 Chen H, Hu X, He C, Wen Y, Ma C, Wang Y. Association of blood eosinophil counts with pulmonary and extrapulmonary comorbidities in patients with chronic obstructive pulmonary disease: data from NHANES 2013-2018. BMC pulmonary medicine 2025. link 100 Harvey BP, Barenfeld E, Fors A, Ekman I, Swedberg K, Gyllensten H. Economic evaluation of a person-centred care intervention with a digital platform and structured telephone support for people with chronic heart failure and/or chronic obstructive pulmonary disease: results from a randomised controlled trial in Sweden. 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