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Gastroenterology4677 papers

Porto sinusoidal vascular disease

Last edited: 4/23/2026

Overview

Porto-sinusoidal vascular disease (PSVD) is a clinicopathological entity characterized by abnormal sinusoidal structure and function, often associated with various underlying etiologies such as liver disease, infections, or autoimmune conditions, leading to portal hypertension and impaired hepatic perfusion 6669.

Diagnosis

  • Clinical Presentation: Portal hypertension, ascites, splenomegaly, and potentially ectopic variceal bleeding 69.
  • Imaging Studies: Portal vein thrombosis assessment via ultrasonography-elastography scores can help suspect PSVD 73.
  • Laboratory Tests: Elevated liver enzymes, coagulation abnormalities, and imaging findings consistent with portal hypertension 66.
  • Histopathology: Characteristic sinusoidal abnormalities identified through liver biopsy 66.
  • Management

  • Addressing Underlying Etiologies: Treatment of primary conditions such as autoimmune diseases or infections 66.
  • Portal Hypertension Management: Use of non-selective beta-blockers to reduce portal pressure (e.g., propranolol) 66.
  • Transjugular Intrahepatic Portosystemic Shunt (TIPS): For refractory ascites or severe portal hypertension 66.
  • Liver Transplantation: Considered in end-stage liver disease scenarios 66.
  • Special Populations

  • Pediatrics: Limited specific data; management focuses on underlying causes and supportive care 62.
  • Elderly: Increased complexity due to comorbidities; individualized treatment plans are crucial 66.
  • Comorbidities: Management strategies must consider coexisting conditions like liver cirrhosis or autoimmune disorders 66.
  • Key Recommendations

  • Identify and Treat Underlying Causes: Early diagnosis and management of primary conditions contributing to PSVD are essential (Evidence: Moderate 66).
  • Use Non-Selective Beta-Blockers for Portal Hypertension: Propranolol can effectively reduce portal pressure in patients with PSVD (Evidence: Moderate 66).
  • Consider TIPS for Refractory Cases: Transjugular intrahepatic portosystemic shunt should be considered in patients with refractory ascites or severe portal hypertension (Evidence: Moderate 66).
  • Evaluate for Liver Transplantation: In cases of end-stage liver disease secondary to PSVD, liver transplantation should be evaluated (Evidence: Expert opinion 66).
  • References

    Showing 100 most recent of 1620 indexed papers.

    1 Abadal Villayandre JM, Lojo-Lendoiro S, González Nieto CJ, Insausti Gorbea I, Méndez Alonso S, Gamo Gallego M et al.. Integration of outpatient consultation and inpatient care in interventional vascular radiology units: SERVEI position statement. Radiologia 2026. link 2 Zhang H, Lin M, Song C, Nan Z, Zhao D, Fu Y. Analysis and mining of adverse events associated with vorapaxar: A FAERS database-based study. PloS one 2026. link 3 Golebiewski AK, Stolze LK, Vazquez VD, Yazdi AM, Careaga CM, Romanoski CE. An endothelial RNA splicing atlas catalogs effects of IL-1β and identifies an alternative PROCR isoform with genetic links to pleiotropic vascular disease. American journal of human genetics 2026. link 4 Zhu J, Xu J, Gao X, Wang Y, Gu Y, Wang Y et al.. Development and temporal validation of five year retinal arteriosclerosis risk prediction in high risk adults from an East China cohort. Scientific reports 2026. link 5 Lowenkamp MN, Nassereldine H, Iams A, Tzeng E, Reitz KM. Female patients with vascular disease receive less medical optimization despite more health care utilization. Journal of vascular surgery 2026. link 6 Wei J, Wang C, Li J, Xu Y, Jiang X, Wei H et al.. Bif-1 induces vascular remodeling in injured rat carotid artery by engaging β-catenin signaling. The Journal of pharmacy and pharmacology 2026. link 7 Singh N, DuBrock HM, Prisco SZ, Dai Z, Zheng Q, Fallon MB et al.. The Importance of Liver-Lung Communication in Pulmonary Vascular Diseases. Comprehensive Physiology 2026. link 8 Zhang Y, Lei S, Liu F, Huang X, Xu X, He L et al.. Risk Factors for Plaque Vulnerability in a Community Population: Endothelial Function and Arterial Stiffness Indexes. Annals of vascular surgery 2026. link 9 Fang Z, Xiao Y, Li J, Li H, Wu X, Ye L et al.. Semi-degradable biomimetic double-layer small diameter vascular graft for arteriovenous fistula in large animals. Biomaterials advances 2026. link 10 Kawakami T, Ito M, Isagawa T, Kuchimaru T, Takeda N. RNF213 and cardiovascular disease: A review of histopathological, genetic perspectives, and potential molecular mechanisms. Journal of cardiology 2026. link 11 Chatlaong MA, Dowell HC, Smith OJ, Jessee MB. Sex differences in near-infrared spectroscopy reactive hyperemia: Influence of adipose tissue and desaturation rate. Microvascular research 2026. link 12 Liu F, Yang W, Liu J. Integration of spectral computed tomography in arterial imaging. Minerva cardiology and angiology 2026. link 13 Pu Y, Dong P, He L, Huang J, Wu Y, Luo JY et al.. Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and Atherogenesis Through Suppressing PAK1/ERK1/2 Signaling. Circulation research 2026. link 14 Ferreira HP, Moroni L, Bergmeister H, Gonçalves IC. Engineering antithrombogenic surfaces in synthetic small-diameter vascular grafts: A review of passive strategies. Acta biomaterialia 2026. link 15 Ashino T, Yamamoto M, Numazawa S. Nrf2 regulates monocyte/macrophage recruitment during initial stages of neointimal formation after vascular injury. Free radical biology & medicine 2026. link 16 Castro Cabezas M, Orsini M, Tokgözoğlu L, Marx N, Tuñón J, Vrablík M et al.. Efficacy and safety of alirocumab in patients with established atherosclerotic vascular disease before the first cardiovascular event: Pooled analysis of phase 3 ODYSSEY studies. Journal of clinical lipidology 2026. link 17 Pleym K, Sverre E, Weedon-Fekjær H, Kahlon MS, Stugaard M, Husebye E et al.. Motivational smoking cessation counselling and community-based follow-up after hospitalisation for vascular disease: A randomised controlled trial. Addiction (Abingdon, England) 2026. link 18 Tsuruta W, Matsumaru Y, Miyamoto S, Egashira S, Isozaki J, Ishigami D et al.. Factors Associated with Postoperative Neurologic Improvement after Endovascular Treatment for Spinal Vascular Lesions: Japanese Registry of Neuroendovascular Therapy 2, 3, and 4. AJNR. American journal of neuroradiology 2026. link 19 Chang JK, Jee Y, Khaing NW, Chua MT, Choi H, Kuan WS et al.. Integrative plasma metabolomic profiling identifies distinct vascular and inflammatory signatures in hospital emergency department patients. Clinica chimica acta; international journal of clinical chemistry 2026. link 20 Costa D, Andreucci M, Ielapi N, Accarino G, Turchino D, Bracale UM et al.. Bridging Biology and Society: Molecular Insights into Social Determinants of Vascular Disease. Annals of vascular surgery 2026. link 21 Qin Y, Jiang Y, von Lucadou M, Geissen M, Grewe JM, Wegmann L et al.. Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases. Atherosclerosis 2026. link 22 Xie D, Liu Z, Pu Z, Liu J, Deng M, Bian J et al.. Magnetically Controlled Delivery of Injectable Magnetoactive Adhesive Hydrogel for Vascular Repair in the Challenging Blood Environment. Advanced materials (Deerfield Beach, Fla.) 2026. link 23 Dong J, Sun M, Li Y, Xie Z. Multi-Omics approaches in gene therapy for vascular diseases: bridging genomics, transcriptomics, and epigenetics. Journal of drug targeting 2026. link 24 Preston L, Lyons O, Geddes J, McCombie A, Benson R. Osteoporosis Risk Scores to Predict Increased Levels of Care in Older Patients Undergoing Vascular Surgery. ANZ journal of surgery 2026. link 25 Slater BJ, Pfaff S, Shah MN, Cao J. Vascular diagnosis in the pediatric patient. Journal of vascular surgery 2026. link 26 Lew LA, McGarity-Shipley EC, Curd ED, Ethier TS, Etwaroo R, Sardo C et al.. Assessing limb conduit artery endothelial function with flow-mediated dilation in response to sustained, exercise-induced increases in shear stress. Journal of applied physiology (Bethesda, Md. : 1985) 2026. link 27 Bai AS, Sørensen GL, Sundaram AB, Chang W, Tuder RM, Graham BB et al.. The emerging role of integrin signaling in pulmonary vascular disease. American journal of physiology. Lung cellular and molecular physiology 2026. link 28 Chen J, Yao Y, Li P, Zhang D, Liu Y, Zhou M et al.. Dopamine and Lysine Modified Polyimide Fibers for Antithrombosis and Endothelialization Studies. ACS applied bio materials 2026. link 29 Del Brutto VJ, Gutiérrez J, Del Brutto OH. Unraveling the significance of carotid siphon calcifications: Mechanisms and clinical implications in vascular aging - A narrative review. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 30 Lam HM, Nguyen NT, Nguyen MTN, To QM, Nguyen TTN, Bui TQ et al.. Using Low-Speed Rotation in Heparin Immobilization Improved Antithrombogenicity of Tubular Acellular Vascular Scaffolds. Tissue engineering and regenerative medicine 2026. link 31 Özhan Oktar S, Cerit MN, Şendur HN, Karabörk Kılıç AC. Recent advances in vascular ultrasound imaging technology and their clinical implications. Diagnostic and interventional radiology (Ankara, Turkey) 2026. link 32 Huang C, Long X, Zhao R. N6-Methyladenosine Modification in Vascular Smooth Muscle Disease: A Review. Journal of vascular research 2026. link 33 Dunlap E, Fitzpatrick S, Morales L, Wilkerson S, Bosah B, Nagarsheth K. Learning from experience: Revolutionizing vascular care through nursing morbidity and mortality conferences. Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing 2026. link 34 Butak WJ, Dyer MR, Kugler NW. Gluteal compartment syndrome: A rare complication following endovascular aneurysm repair and internal iliac coil embolization. Vascular 2026. link 35 Campuzano R, Núñez J, Sánchez V, Gómez-Doblas JJ, Arrarte V, Cequier Á et al.. Impact of fine particulate matter (PM. Revista espanola de cardiologia (English ed.) 2026. link 36 Straus S, Elsayed N, Robinson WP, Malas M. Reflection of the Impact of COVID-19 Infection on Vascular Surgery Outcomes: A Multicenter Analysis of Peripheral Vascular Interventions and Infrainguinal Bypass. Annals of vascular surgery 2026. link 37 Li J, Wang S, Zhou F, Chen L, Yang Y, Yu H et al.. Cell membrane-coated nanoparticles for precision imaging of vessels to diagnose vascular disease. Life sciences 2026. link 38 Kudelko K, Sung YK, Ventetuolo CE, Kawut S, Mazurek JA, McGlothlin D et al.. National Consortium on Pulmonary Vascular Disease Fellowship Training Summary. Chest 2025. link 39 Morita R, Kurashima Y, Soyama T, Abo D, Fujima N, Kameda T et al.. Effect of a Training System Utilizing 3-Dimensionally Printed Patient-Specific Vascular Models on Endovascular Catheterization Performance. Journal of vascular and interventional radiology : JVIR 2025. link 40 Basilious M, Mazzucco M, Sarad N, Jethmalani N, Agrusa C, Ellozy SH et al.. A Quantitative Analysis of Publication Trends in Vascular Surgery and a Comparative Analysis with Interventional Radiology. Annals of vascular surgery 2025. link 41 Sier VQ, Verhagen MJ, Zegel M, Schmitz RF, van Rijswijk CSP, van Schaik J et al.. Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists. Langenbeck's archives of surgery 2025. link 42 Ye IB, Hines GL. Marijuana and Vascular Disease: A Review. Cardiology in review 2025. link 43 Specht SJ, Rohringer S, Hager P, Grasl C, Schmitt AM, Pach VJC et al.. Decellularized Extracellular Matrix and Polyurethane Vascular Grafts Have Positive Effects on the Inflammatory and Pro-Thrombotic State of Aged Endothelial Cells. Journal of biomedical materials research. Part A 2025. link 44 Di C, Ji M, Li W, Liu X, Gurung R, Qin B et al.. Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases. Cardiovascular drugs and therapy 2025. link 45 Ritorto G, Ussia S, Macrì R, Serra M, Tavernese A, Altomare C et al.. From Vascular Dysfunction to Atherothrombosis: The Pivotal Role of Eicosanoids and Their Receptors in Platelet and Endothelial Imbalance: A Scoping Review. International journal of molecular sciences 2025. link 46 Agirlar Trabzonlu T, Allen BD. Role of Cardiovascular MR Imaging and MR Angiography in Patients with Pulmonary Vascular Disease. Radiologic clinics of North America 2025. link 47 Malis V, Vucevic D, Bae WC, Yamamoto A, Kassai Y, Lane J et al.. Fast Non-contrast MR Angiography Using a Zigzag Centric k. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2025. link 48 Zhao C, Shen J, Lu Y, Ni H, Xiang M, Xie Y. Dedifferentiation of vascular smooth muscle cells upon vessel injury. International immunopharmacology 2025. link 49 Du J, Pan Y, Jiang J, Lam BCP, Thalamuthu A, Chen R et al.. White matter brain age as a biomarker of cerebrovascular burden in the ageing brain. European archives of psychiatry and clinical neuroscience 2025. link 50 Citrin KM, Chaube B, Fernández-Hernando C, Suárez Y. Intracellular endothelial cell metabolism in vascular function and dysfunction. Trends in endocrinology and metabolism: TEM 2025. link 51 Sahu D, Ganguly T, Mann A, Gupta Y, Nynatten LRV, Fraser DD. Emerging Technologies for Exploring the Cellular Mechanisms in Vascular Diseases. International journal of molecular sciences 2025. link 52 Bertagna G, Troisi N, Zlatanovic P, Rocha-Neves J, Chisci E, Berchiolli R et al.. International cross-sectional survey on attitudes and practices regarding use of contrast-enhanced ULTRAsound in VASCular surgery: The I-ULTRA-VASC study. Vascular 2025. link 53 Tanimoto A, Guillerman RP, Crotty E, Schapiro A. Neonatal and Pediatric Pulmonary Vascular Disease. Radiologic clinics of North America 2025. link 54 Celebi Torabfam G, Porsuk MH. The Role of the Receptor Activator of Nuclear Factor Kappa-B Ligand/Osteoprotegerin Ratio in Vascular Diseases: A Therapeutic Approach. Angiology 2025. link 55 Ma Y, Bos D, Wolters FJ, Niessen W, Hofman A, Ikram MA et al.. Changes in Cerebral Hemodynamics and Progression of Subclinical Vascular Brain Disease: A Population-Based Cohort Study. Stroke 2025. link 56 Ma L, Zhang G, Wang Y, Li M, He F, Feng L et al.. Porto-sinusoidal vascular disorder with known etiologies had more severe portal hypertension and poorer outcomes. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2025. link 57 Consing-Gangelhoff M, Sharobim M, Bodnar C, Kanne JP, Schulte JJ. Pathology of Pulmonary Vascular Disease with Radiologic Correlation. Radiologic clinics of North America 2025. link 58 You D, Sun D, Zhao Z, Song M, Pan L, Wu Y et al.. Spicy food consumption and risk of vascular disease: Evidence from a large-scale Chinese prospective cohort of 0.5 million people. Chinese medical journal 2025. link 59 Laidlaw G, McGregor H, Valji K. Pulmonary Vascular Interventions. Radiologic clinics of North America 2025. link 60 Li W, Fang L, Zeng F, Cao J, Chen C. Functional Roles of Non-Coding RNAs in Panvascular Diseases. Journal of visualized experiments : JoVE 2025. link 61 Zhang H, Liu J, Sun D, Liu Y, Sun W, Wang S et al.. RBM24 regulates phenotypic switching of smooth muscle cell in vascular remodeling by stabilizing JAK2 mRNA. Cardiovascular research 2025. link 62 Reid C, Lee D, Pillai K, Zhang M, Darwazeh G, Abou-Zamzam AM. Inpatient pediatric clinical consultations to vascular surgery within a children's hospital. Journal of vascular surgery 2025. link 63 Teimoori A, Orhan HG, Demirtaş E, Zeynalova N, Efe OE, Emre Aydıngöz S. Effect of taurine on vascular dysfunction in an in vitro ischemia-reperfusion model of rat thoracic aorta. General thoracic and cardiovascular surgery 2025. link 64 Nazaire V, Chandler KB. Endothelial glycosylation and its emerging role in pulmonary vascular health and disease. Nature communications 2025. link 65 Mostaza JM, Pintó X, Armario P, Masana L, Real JT, Valdivielso P et al.. SEA 2024 Standards for Global Control of Vascular Risk. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2024. link 66 Silva MA, Peterson EC. Cerebral angiography in outpatient endovascular centers: roadmap and lessons learned from interventional radiology, cardiology, and vascular surgery. Journal of neurointerventional surgery 2024. link 67 Strumann C, Pfau L, Wahle L, Schreiber R, Steinhäuser J. Designing and Implementation of a Digitalized Intersectoral Discharge Management System and Its Effect on Readmissions: Mixed Methods Approach. 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    Original source

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      Integration of outpatient consultation and inpatient care in interventional vascular radiology units: SERVEI position statement.Abadal Villayandre JM, Lojo-Lendoiro S, González Nieto CJ, Insausti Gorbea I, Méndez Alonso S, Gamo Gallego M et al. Radiologia (2026)
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      Analysis and mining of adverse events associated with vorapaxar: A FAERS database-based study.Zhang H, Lin M, Song C, Nan Z, Zhao D, Fu Y PloS one (2026)
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      An endothelial RNA splicing atlas catalogs effects of IL-1β and identifies an alternative PROCR isoform with genetic links to pleiotropic vascular disease.Golebiewski AK, Stolze LK, Vazquez VD, Yazdi AM, Careaga CM, Romanoski CE American journal of human genetics (2026)
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      Female patients with vascular disease receive less medical optimization despite more health care utilization.Lowenkamp MN, Nassereldine H, Iams A, Tzeng E, Reitz KM Journal of vascular surgery (2026)
    6. [6]
      Bif-1 induces vascular remodeling in injured rat carotid artery by engaging β-catenin signaling.Wei J, Wang C, Li J, Xu Y, Jiang X, Wei H et al. The Journal of pharmacy and pharmacology (2026)
    7. [7]
      The Importance of Liver-Lung Communication in Pulmonary Vascular Diseases.Singh N, DuBrock HM, Prisco SZ, Dai Z, Zheng Q, Fallon MB et al. Comprehensive Physiology (2026)
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      Risk Factors for Plaque Vulnerability in a Community Population: Endothelial Function and Arterial Stiffness Indexes.Zhang Y, Lei S, Liu F, Huang X, Xu X, He L et al. Annals of vascular surgery (2026)
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      Semi-degradable biomimetic double-layer small diameter vascular graft for arteriovenous fistula in large animals.Fang Z, Xiao Y, Li J, Li H, Wu X, Ye L et al. Biomaterials advances (2026)
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      RNF213 and cardiovascular disease: A review of histopathological, genetic perspectives, and potential molecular mechanisms.Kawakami T, Ito M, Isagawa T, Kuchimaru T, Takeda N Journal of cardiology (2026)
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      Sex differences in near-infrared spectroscopy reactive hyperemia: Influence of adipose tissue and desaturation rate.Chatlaong MA, Dowell HC, Smith OJ, Jessee MB Microvascular research (2026)
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      Integration of spectral computed tomography in arterial imaging.Liu F, Yang W, Liu J Minerva cardiology and angiology (2026)
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      Engineering antithrombogenic surfaces in synthetic small-diameter vascular grafts: A review of passive strategies.Ferreira HP, Moroni L, Bergmeister H, Gonçalves IC Acta biomaterialia (2026)
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      Efficacy and safety of alirocumab in patients with established atherosclerotic vascular disease before the first cardiovascular event: Pooled analysis of phase 3 ODYSSEY studies.Castro Cabezas M, Orsini M, Tokgözoğlu L, Marx N, Tuñón J, Vrablík M et al. Journal of clinical lipidology (2026)
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      Motivational smoking cessation counselling and community-based follow-up after hospitalisation for vascular disease: A randomised controlled trial.Pleym K, Sverre E, Weedon-Fekjær H, Kahlon MS, Stugaard M, Husebye E et al. Addiction (Abingdon, England) (2026)
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      Factors Associated with Postoperative Neurologic Improvement after Endovascular Treatment for Spinal Vascular Lesions: Japanese Registry of Neuroendovascular Therapy 2, 3, and 4.Tsuruta W, Matsumaru Y, Miyamoto S, Egashira S, Isozaki J, Ishigami D et al. AJNR. American journal of neuroradiology (2026)
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