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Triglyceride deposit cardiomyovasculopathy — Clinical Guidelines

Overview

Triglyceride deposit cardiomyovasculopathy is a condition associated with elevated triglyceride levels, which can contribute to cardiovascular disease 8. The triglyceride-glucose (TyG) index, a marker of insulin resistance, has been linked to increased cardiovascular risk, including heart failure, arterial stiffness, and coronary artery calcification 3 4.

Diagnosis

Hypertriglyceridemia (HTG) is defined as triglyceride levels ≥1.7 mmol/L 6.

The triglyceride-glucose (TyG) index is proposed as a surrogate marker for insulin resistance 3.

Management

Soluble fiber supplementation has been shown to reduce triglyceride levels 5.

Volanesorsen is an antisense oligonucleotide that significantly reduces triglyceride levels in patients with severe hypertriglyceridemia 7.

Obicetrapib, a CETP inhibitor, has shown potential in modifying lipid parameters, though it did not significantly alter triglyceride levels in one meta-analysis 2.

Key Recommendations

Elevated TyG index is associated with an increased risk of arterial stiffness and coronary artery calcification 4. (Evidence: Moderate)

An elevated TyG index is associated with a significantly increased risk of heart failure 3. (Evidence: Moderate)

Soluble fiber supplementation significantly reduces triglyceride levels 5. (Evidence: Strong)

Volanesorsen is associated with a significant reduction in triglycerides in patients with severe hypertriglyceridemia 7. (Evidence: Strong)

References

1 Ballena-Caicedo J, Zuzunaga-Montoya FE, Loayza-Castro JA, Vásquez-Romero LEM, Tapia-Limonchi R, De Carrillo CIG et al.. Global prevalence of dyslipidemias in the general adult population: a systematic review and meta-analysis. Journal of health, population, and nutrition 2025. link 2 Bhatti MI, Safiullah M, Farhan K, Ali A, Abdullah S, Ali A et al.. Obicetrapib and its impact on lipid parameters: A comprehensive meta-analysis of the latest evidence. Journal of clinical lipidology 2025. link 3 Khalaji A, Behnoush AH, Khanmohammadi S, Ghanbari Mardasi K, Sharifkashani S, Sahebkar A et al.. Triglyceride-glucose index and heart failure: a systematic review and meta-analysis. Cardiovascular diabetology 2023. link 4 Liu F, Ling Q, Xie S, Xu Y, Liu M, Hu Q et al.. Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis. Cardiovascular diabetology 2023. link 5 Ghavami A, Ziaei R, Talebi S, Barghchi H, Nattagh-Eshtivani E, Moradi S et al.. Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Advances in nutrition (Bethesda, Md.) 2023. link 6 Tan HLE, Hure A, Peel R, Hancock S, Attia J. Prevalence and clinical risk prediction of hypertriglyceridaemia in a community cohort. Internal medicine journal 2023. link 7 Calcaterra I, Lupoli R, Di Minno A, Di Minno MND. Volanesorsen to treat severe hypertriglyceridaemia: A pooled analysis of randomized controlled trials. European journal of clinical investigation 2022. link 8 Brotons C, Moral I, González J, Fernández D, Puig M, Vilella MT. Epidemiology of hypertriglyceridaemia. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2021. link

Triglyceride deposit cardiomyovasculopathy

Overview

Diagnosis

Management

Key Recommendations

References

Original source