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Dermatology2 papers

Thyroid follicular nodular disease

Last edited: 4/15/2026

Overview

Follicular occlusion disease is a rare dermatological condition characterized by the abnormal accumulation and transepidermal elimination of elastic tissue, often associated with chronic follicular inflammation 1.

Diagnosis

  • Histopathologic examination revealing increased and abnormal elastic tissue deposition 1.
  • Identification of transepidermal elimination of elastic fibers on dermoscopy or biopsy 1.
  • Exclusion of other conditions presenting similar clinical features, such as elastosis perforans serpiginosa 1.

    • Management

  • No specific first-line pharmacological treatments mentioned; management primarily supportive and symptomatic 1.
  • Topical corticosteroids may be considered for associated inflammation 1.
  • Regular monitoring and dermatologic follow-up essential for assessing disease progression 1.

    • Special Populations

  • No specific data provided regarding pregnancy, pediatrics, elderly, or comorbidities 1.

    • Key Recommendations

  • Histopathologic confirmation is crucial for diagnosing follicular occlusion disease (Evidence: Expert opinion 1).
  • Focus on supportive care and monitoring due to limited evidence for specific treatments (Evidence: Expert opinion 1).
  • Consider topical corticosteroids for managing associated inflammatory symptoms (Evidence: Expert opinion 1).

    • References

    1 Hyland CH, Kheir SM. Follicular occlusion disease with elimination of abnormal elastic tissue. Archives of dermatology 1980. link

    Original source

    1. [1]
      Follicular occlusion disease with elimination of abnormal elastic tissue. — Hyland CH, Kheir SM Archives of dermatology (1980)
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