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Sickle cell nephropathy

Last edited: 4/10/2026

Overview

Sickle cell nephropathy is a complication of sickle cell disease that affects the kidneys. Early detection and intervention are crucial for improving patient outcomes 1.

Diagnosis

  • Assessment of glomerular filtration rate (GFR) 1.
  • Evaluation for tubular dysfunction 1.
  • Measurement of proteinuria 1.

    • Management

  • Preventing or slowing the progression of nephropathy 1.

    • Key Recommendations

  • Utilize improved measures of glomerular filtration rate, tubular dysfunction, and proteinuria to detect and monitor sickle cell nephropathy 1. (Evidence: Expert opinion)
  • Implement strategies to prevent or slow the development of sickle cell nephropathy to improve outcomes 1. (Evidence: Expert opinion)

    • References

    1 Scheinman JI. Tools to detect and modify sickle cell nephropathy. Kidney international 2006. link

    Original source

    1. [1]
      Tools to detect and modify sickle cell nephropathy. — Scheinman JI Kidney international (2006)
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