Overview
Primary malignant germ cell neoplasms of the testis are a group of cancers arising from germ cells within the testicle. These include both seminomas and nonseminomas, requiring a multidisciplinary approach for diagnosis, treatment, and follow-up 1.Diagnosis
Diagnostic workup includes imaging and tumor markers 1.
Histologic classification into seminoma or nonseminoma is crucial for treatment planning 1.Management
Treatment recommendations are based on the specific type of germ cell tumor (seminoma or nonseminoma) 1.
Management involves a multidisciplinary approach 1.Key Recommendations
The NCCN Guidelines for Testicular Cancer provide recommendations for the multidisciplinary approach to the diagnostic workup, treatment, and follow-up for testicular germ cell tumors 1.
Current treatment recommendations and supporting clinical data for seminomas are presented in the NCCN Guidelines for Testicular Cancer, Version 2.2025 1.
The guidelines cover both seminoma and nonseminoma subtypes 1.References
1 Gilligan T, Lin DW, Adra N, Bagrodia A, Feldman DR, Yamoah K et al.. NCCN Guidelines® Insights: Testicular Cancer, Version 2.2025. Journal of the National Comprehensive Cancer Network : JNCCN 2025. link