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Dermatology4 papers

Metastatic Merkel cell carcinoma to skin

Last edited: 4/10/2026

Overview

Merkel cell carcinoma (MCC) is a rare, highly malignant skin cancer with a high propensity for recurrence and metastasis 1. Its incidence has been increasing in recent years 1. MCC is considered a highly immunogenic tumor 1.

Diagnosis

No information on diagnosis was provided in the abstracts.

Management

No information on management was provided in the abstracts.

Special Populations

No information on special populations was provided in the abstracts.

Key Recommendations

  • Resection margins for the primary tumor should be considered 1. (Evidence: Expert opinion)
  • Sentinel lymph node biopsy is a consideration 1. (Evidence: Expert opinion)
  • Postoperative radiotherapy should be considered 1. (Evidence: Expert opinion)
  • Chemotherapy is indicated for advanced disease 1. (Evidence: Expert opinion)
  • References

    1 Nakamura M, Nagase K, Kato J, Yasuda M, Tomita N, Kobayashi T et al.. Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025. The Journal of dermatology 2025. link

    Original source

    1. [1]
      Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025.Nakamura M, Nagase K, Kato J, Yasuda M, Tomita N, Kobayashi T et al. The Journal of dermatology (2025)

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