Overview
Senile dementia, often encompassing Alzheimer's disease and other dementias, refers to cognitive decline associated with aging, characterized by memory loss, impaired thinking, and changes in behavior and social functioning. 56Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 575 indexed papers.
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How a geriatrician-led emergency department model works in practice: a realist evaluation. Age and ageing 2026. link 7 Thapa SK, Li J, Mach J, Hilmer SN, Kirkpatrick CMJ. Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review. Drugs & aging 2026. link 8 Liu F, Schrack JA, Walker KA, Walston J, Mathias RA, Griswold ME et al.. The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study. European journal of epidemiology 2026. link 9 Gengxin Y, Xuehan M, Xinyu W, Yali Y, Yiran X, Lishuang Z et al.. Association between sarcopenic obesity and risk of frailty in older adults: a systematic review and meta-analysis. Age and ageing 2025. link 10 Proaño-Zamudio JA, Arda Y, Perkins TM, Nzenwa IC, Argandykov D, Rafaqat W et al.. Frailty impacts outcomes for all older adult age groups in emergency laparotomy. American journal of surgery 2025. link 11 Price A, Pearce L, Griffiths J, Smith J, Tomkow L, Martin P. Estimating the effect of frailty on longer-term survival following emergency laparotomy: an observational study using National Emergency Laparotomy Audit data. Anaesthesia 2025. link 12 Umegaki H. Frailty, multimorbidity, and polypharmacy: Proposal of the new concept of the geriatric triangle. Geriatrics & gerontology international 2025. link 13 Cruz-Jentoft AJ, Bruyère O, Cherubini A, Clarfield AM, Gąsowski J, Haunton VJ et al.. Guidance on the production of EuGMS guidelines. European geriatric medicine 2025. link 14 Wee R. Human rights and the comprehensive geriatric assessment: Is the standard of care compatible with a human rights approach?. Australasian journal on ageing 2025. link 15 Kumlehn B, Brefka S, Kocar T, Verri FM, Wirth R, Denkinger M. Clinical Practice Guideline: Comprehensive Geriatric Assessment in the Hospital. Deutsches Arzteblatt international 2025. link 16 Mayan I, Yaffe K, Rose AJ, Allen IE, Yakov G, Katz G et al.. The return home model: design and implementation of a geriatric home-care model for long-term care eligible older adults. Israel journal of health policy research 2025. link 17 de Groot AJ, Wattel EM, van Balen R, Hertogh CMPM, van der Wouden JC. Referral to Geriatric Rehabilitation in the Netherlands, an Exploratory Study of Patient Characteristics. Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses 2025. link 18 Castagna A, Ruotolo G, Azzini M, Aprile PL, Vanacore N, Pilotto A et al.. Reflections on the implementation of the Italian guidelines on comprehensive geriatric assesment for the older persons. Aging clinical and experimental research 2025. link 19 Lo YT, Li SM, Hu CJ, Hsiao SH, Yang YC, Yang DC. What is HOME? Exploring learning themes in a home-visit educational program for postgraduate residents in Taiwan. European geriatric medicine 2025. link 20 Duque S, Piotrowicz K, Masud T, Wissendorff Ekdahl A, Herghelegiu AM, Pavic T et al.. Building a pan-European network to bridge gaps in geriatric medicine education: the PROGRAMMING COST Action 21,122-a call for endorsement. European geriatric medicine 2025. link 21 Singh N, Faye AS, Abidi MZ, Grant SJ, DuMontier C, Iyer AS et al.. Frailty integration in medical specialties: Current evidence and suggested strategies from the Clin-STAR frailty interest group. Journal of the American Geriatrics Society 2025. link 22 Andersen LH, Løfgren B, Skipper M, Krogh K, Jensen RD. Enhancing ward rounds for older patients with frailty: a modified Delphi process. BMC medical education 2025. link 23 Sasu GV, Ciubotaru BI, Goga N, Vasilățeanu A. Addressing Missing Data Challenges in Geriatric Health Monitoring: A Study of Statistical and Machine Learning Imputation Methods. Sensors (Basel, Switzerland) 2025. link 24 Guo R, Fan H, Xiao S, Zheng Z, Yang F, Xiao Y et al.. Development and usability testing of an integrated geriatric care model (SMART system) to promote integrated home-based geriatric care. BMC geriatrics 2025. link 25 Thompson MQ, Fatema NE, Tucker GR, Khalid A, Huang Y, Smyth CR et al.. Frailty in general medicine patients receiving geriatric medicine liaison services is predictive of adverse outcomes. Australasian journal on ageing 2025. link 26 Eagleton G, Güven R, Thorsteinsdóttir T, Mirkes E, van Oppen JD. Concordance with routine Clinical Frailty Scale screening in the frailty in European emergency departments (FEED) study. International emergency nursing 2025. link 27 Shin J, Choi J, Kweon HJ, Han Y, Lee M. Hospital frailty risk score using electronic medical records and geriatric syndromes in an acute-care hospital. Geriatric nursing (New York, N.Y.) 2025. link 28 Paraskevopoulos A, Wettermark B, Tsiligianni I. Factors Influencing General Practitioners' Deprescribing Decisions for Older Adults, with Insights into Frailty: a Qualitative Study in Greek Primary Care. Drugs & aging 2025. link 29 Fujita K, Mach J, Hilmer SN. Using Computational Video Analysis in Aging Mice to Evaluate the Effects of Chronic Monotherapy, Polypharmacy, and Deprescribing Over Time. The journals of gerontology. Series A, Biological sciences and medical sciences 2025. link 30 Radcliffe E, Saucedo AR, Howard C, Sheikh C, Bradbury K, Rutter P et al.. Development of a complex multidisciplinary medication review and deprescribing intervention in primary care for older people living with frailty and polypharmacy. PloS one 2025. link 31 Jankowska-Polańska B, Tomasiewicz A, Polański J, Tański W. Association between frailty, malnutrition, and chronic diseases in community-based patients in Poland. Nutrition (Burbank, Los Angeles County, Calif.) 2025. link 32 Mose K, Lundby C, Ernst MT, Ryg J, Pottegård A, Rasmussen L. Use of Potentially Inappropriate Medications Identified by STOPPFrail Among Danish Care Home Residents: A Nationwide Drug Utilisation Study. Basic & clinical pharmacology & toxicology 2025. link 33 Montalbo J, Dintsios CM, Abraham J, Drewelow E, Ritzke M, Mortsiefer A et al.. Cost-Effectiveness of Family Conferences to Reduce Polypharmacy in Frail Older Adults. Journal of the American Geriatrics Society 2025. link 34 De Luca V, Virgolesi M, Cuomo A, Lemmo D, Perillo M, Canfora F et al.. Digital interventions addressing the unmet needs of older adults with multimorbidity: a mixed-methods persona design approach. Frontiers in public health 2025. link 35 Lin LY, Hsiao FY, Huang ST, Lai HY, Loh CH, Chen LK. Multi-trajectories of polypharmacy composition and clinical outcomes by frailty status: a longitudinal cohort study. Age and ageing 2025. link 36 Malara A, Zucchelli A, Trevisan C, Borselli G, Incalzi RA, Onder G et al.. Polypharmacy appropriateness in Italian Long-Term Care Facilities: the nationwide prescription day point survey. Aging clinical and experimental research 2025. link 37 Liang JX, Thai L, Healy M, Idris AM, Chin JW, Grossman C. Deprescribing in Australian residential aged care facilities: A scoping review. Australasian journal on ageing 2025. link 38 Guellich A, Oubaya N, Cogneau J, Lacoin F, Clerc P, Audureau E et al.. Identifying patterns of multimorbidity, polypharmacy and frailty in the elderly: a clustering analysis of baseline data from a French, randomised, controlled trial in primary care. BMJ open 2025. link 39 Lin WL, Hsueh TP, Wang YC, Chiu JT, Yan SS, Wang YF et al.. Implications of comprehensive geriatric assessment and Traditional Chinese Medicine constitution types for integrative geriatric care. Archives of gerontology and geriatrics 2025. link 40 Papakitsou I, Papazachariou A, Filippatos T. Prevalence, associated factors, and impact of vitamin B12 deficiency in older medical inpatients. European geriatric medicine 2025. link 41 Harbi H, Lundby C, Jensen PB, Larsen SP, Rørbæk LG, Ravn-Nielsen LV et al.. Medication use patterns among older patients in temporary stays in Denmark. European geriatric medicine 2025. link 42 Daimaru K, Hatanaka S, Osuka Y, Kojima N, Maruo K, Sasai H. Association of potentially inappropriate medications with frailty and frailty components in community-dwelling older women in Japan: The Otassha Study. Geriatrics & gerontology international 2025. link 43 Thandi M, Gibb A, Price M, Baumbusch J, Wong ST. Development and testing of an electronic frailty index using Canadian electronic medical record data in primary care. BMC primary care 2025. link 44 Previdoli G, Simms-Ellis R, Silcock J, Alldred DP, Cheong VL, Tyndale-Biscoe S et al.. Supporting Older People Living With Frailty to Self-Manage Multiple Medicines: An Experience-Based Co-Design of a Complex Intervention Developed in UK Primary Care. Health expectations : an international journal of public participation in health care and health policy 2025. link 45 Alshatti D, Cox AR, Hirsch C, Cheng V, Aston J. Evaluation of deprescribing services in frail patients: a systematic review. The International journal of pharmacy practice 2025. link 46 Morisaki Y, Takashima M, Maeda-Minami A, Izumi S, Suzuki M, Funakoshi R et al.. Relationship Between Frailty and Drug Burden Index in Older Hospitalized Patients. In vivo (Athens, Greece) 2025. link 47 Serra-Prat M, Fortuny Borsot A, Burdoy E, Lavado Cuevas À, Muñoz Ortiz L, Cabré M. Frailty reversal and its main determinants: a population-based observational and longitudinal study. Family medicine and community health 2025. link 48 Ilkin Naharci M. Frail Older Adults with High Anticholinergic Burden are at Risk of Orthostatic Hypotension. Journal of the American Medical Directors Association 2025. link 49 Jung HW, Park SJ, Jhang H, Park K, Baek J, Lee M et al.. Impact of Potentially Inappropriate Medication on Disability and Mortality in Older Adults: Nationwide Population-Based Study in Korea. The journals of gerontology. Series A, Biological sciences and medical sciences 2025. link 50 Chen Y, Lin S, Yang S, Qi M, Ren Y, Tian C et al.. Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics. Journal of advanced research 2025. link 51 Ren Z, Liu G, Zhao J, Ma Q, Zou X, Li X et al.. Cross-sectional and longitudinal associations between Life's Essential 8 and frailty in community-dwelling older adults. Frontiers in public health 2025. link 52 Courish MK, O'Brien MW, Maxwell SP, Mekari S, Kimmerly DS, Theou O. Relationship between frailty and executive function by age and sex in the Canadian Longitudinal Study on Aging. GeroScience 2025. link 53 Xiong YJ, Meng XD, Xu HZ, Zhu XY. Association of frailty index with all-cause and cardiovascular mortality with different diabetic status: NHANES 1999-2018. Acta diabetologica 2025. link 54 Goh SSN, Zhao J, Drakeford PA, Chen Q, Lim WW, Li AL et al.. Assessing the impact of frailty in elderly patients undergoing emergency laparotomies in Singapore. Annals of the Academy of Medicine, Singapore 2024. link 55 Snitkjær C, Rehné Jensen L, Í Soylu L, Hauge C, Kvist M, Jensen TK et al.. Impact of clinical frailty on surgical and non-surgical complications after major emergency abdominal surgery. BJS open 2024. link 56 Patel SV, Rockwood K. Young Investigator Interview with CSCI Awardee, Dr. Kenneth Rockwood. Clinical and investigative medicine. Medecine clinique et experimentale 2024. link 57 Chao CT. Literacy for Frailty among Undergraduate Medical Education: An Under-Recognized Opportunity to Improve Geriatric Care. Aging and disease 2024. link 58 Villars H, Balardy L, Ghisolfi A, Blain H, Rolland Y. "Geriatric Team Health Care Pathways": An Organizational Innovation to Enhance Care Pathways of Long-Term Care Facilities' Residents in the French Region of Occitania. Journal of the American Medical Directors Association 2024. link 59 Nguyen TV, Tran GM, Nguyen TT, Le HT, Tran BL, Ngo TH et al.. Simplified clinical frailty scale design, validation, and adaptation in older patients. European review for medical and pharmacological sciences 2024. link 60 Shrestha S, Poudel A, Steadman KJ, Nissen LM. Deprescribing Tool for Older PeoPle with Limited-life Expectancy (De-TOPPLE) version 1: Development and validation using a modified Delphi technique. Basic & clinical pharmacology & toxicology 2024. link 61 Hammel IS, Chapman EN. Frailty training among healthcare professionals. The journal of nutrition, health & aging 2024. link 62 Li J, Hosoyama T, Shigemizu D, Yasuoka M, Kinoshita K, Maeda K et al.. Association between Circulating Levels of CXCL9 and CXCL10 and Physical Frailty in Older Adults. Gerontology 2024. link 63 Zainal N, Azizan A. Bibliometric Insights into Research on Frailty and Falls. Ethiopian journal of health sciences 2024. link 64 Polidori MC. Geroscience in the continuum from healthy longevity to frailty. Zeitschrift fur Gerontologie und Geriatrie 2024. link 65 Tanaka T, Hirano H, Ikebe K, Ueda T, Iwasaki M, Minakuchi S et al.. Consensus statement on "Oral frailty" from the Japan Geriatrics Society, the Japanese Society of Gerodontology, and the Japanese Association on Sarcopenia and Frailty. Geriatrics & gerontology international 2024. link 66 Lovett M, Koto P, Shetty N. Assessing clinical frailty scale scoring by junior medical learners on an inpatient geriatrics consultation service. Gerontology & geriatrics education 2024. link 67 Bari MD, Giordano A, Giannini I, Balzi D, Tonarelli F, Benvenuti E et al.. Effects of the implementation of the dynamic silver code in the emergency department. European journal of internal medicine 2024. link 68 Mahamud I, Haigh R, Shanghavi S. Perioperative geriatrics: A bibliometric analysis of the top 100 cited articles in an emerging specialty. Journal of perioperative practice 2024. link 69 Hilmer SN, Schwartz J, Petrovic M, Walker LE, Thürmann P, Le Couteur DG. Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee. Journal of the American Geriatrics Society 2024. link 70 Wang C, Wang J, Wan R, Kurihara H, Wang M. The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience. Frontiers in endocrinology 2024. link 71 Cheslock M, Nahas A, Orkaby AR, Schwartz AW. Teaching Frailty to Medical Residents: A Needs Assessment Among Geriatrics Faculty. The Journal of frailty & aging 2024. link 72 Azarias E, Thillainadesan J, Hanger C, Scott J, Boudville A, Moran C et al.. Hospital and out-of-hospital services provided by public geriatric medicine departments in Australia and New Zealand. Australasian journal on ageing 2024. link 73 Fernández-Montalbán P, Martínez-Flores S, Mir-Montero M, Arribas López JR, Bibiano-Guillén C, Brañas F. Impact of a geriatric intervention based on the Comprehensive Geriatrics Assessment on avoidable admissions in older patients at risk evaluated in the Emergency Department. Revista espanola de geriatria y gerontologia 2024. link 74 Wilson C, Seaton RA. Antimicrobial Stewardship in the Frail Elderly. British journal of hospital medicine (London, England : 2005) 2024. link 75 Huh Y, Kim YJ, Choi JY, Lee JE, Jung HW, Shin CM et al.. Comparison of anticholinergic burden with chronic polypharmacy on functional decline and mortality in Korean older people: a retrospective nationwide cohort study. BMC geriatrics 2024. link 76 Alamri SH, Mealif HM. Exploring the correlates of frailty among hospitalized older adults: A cross-sectional study in a Saudi teaching hospital. Medicine 2024. link 77 Duncan S, Bergler HU, Menclova A, Pickering JW, Nishtala PS, Ailabouni N et al.. The Drug Burden Index and Level of Frailty as Determinants of Healthcare Costs in a Cohort of Older Frail Adults in New Zealand. Value in health regional issues 2024. link 78 Yoshida Y, Ishizaki T, Masui Y, Miura Y, Matsumoto K, Nakagawa T et al.. Effects of multimorbidity and polypharmacy on physical function in community-dwelling older adults: A 3-year prospective cohort study from the SONIC. Archives of gerontology and geriatrics 2024. link 79 Daimaru K, Osuka Y, Kojima N, Mizukami K, Motokawa K, Iwasaki M et al.. Associations of polypharmacy with frailty severity and each frailty phenotype in community-dwelling older adults: Itabashi Longitudinal Study on Aging. Geriatrics & gerontology international 2024. link 80 Mearns A, Siu ATY, Birdling M, Geddes T, Kenealy H. Preoperative comprehensive geriatric assessment and multidisciplinary team input in older people undergoing elective orthopaedic surgery: A feasibility trial. Australasian journal on ageing 2024. link 81 Woodcock T, Lovett D, Ihenetu G, Novov V, Beaney T, Armani K et al.. Polypharmacy in primary care: A population-based retrospective cohort study of electronic health records. PloS one 2024. link 82 Njoku CM, Barnett F, Fiatarone Singh MA, Valenzuela T, Inskip M. Multifaceted Interventions Inclusive of Medication Optimization for Frailty in Aged Care: A Systematic Review. Journal of the American Medical Directors Association 2024. link 83 Quek HW, Page A, Lee K, Lee G, Hawthorne D, Clifford R et al.. The effect of deprescribing interventions on mortality and health outcomes in older people: An updated systematic review and meta-analysis. British journal of clinical pharmacology 2024. link 84 Previdoli G, Alldred DP, Silcock J, Tyndale-Biscoe S, Okeowo D, Cheong VL et al.. 'It's a job to be done'. Managing polypharmacy at home: A qualitative interview study exploring the experiences of older people living with frailty. Health expectations : an international journal of public participation in health care and health policy 2024. link 85 Liau SJ, Zhao M, Hamada S, Gutiérrez-Valencia M, Jadczak AD, Li L et al.. Deprescribing Opportunities for Frail Residents of Nursing Homes: A Multicenter Study in Australia, China, Japan, and Spain. Journal of the American Medical Directors Association 2024. link 86 Liu X, Zhao R, Zhou X, Yu M, Zhang X, Wen X et al.. Association between polypharmacy and 2-year outcomes among Chinese older inpatients: a multi-center cohort study. BMC geriatrics 2024. link 87 Park SG, Kim H. Lack of Association between Insufficient Intake of Multiple Vitamins and Frailty in Older Adults Who Consume Sufficient Energy and Protein: A Nationwide Cross-Sectional Study. Nutrients 2024. link 88 Fravel MA, Ernst ME, Woods RL, Beilin L, Zhou Z, Orchard SG et al.. Long-term blood pressure variability and frailty risk in older adults. Journal of hypertension 2024. link 89 Tan M, Bhanu C, Frost R. The association between frailty and anxiety: A systematic review. International journal of geriatric psychiatry 2023. link 90 Parsopoulou Walker K, Alegre Rosiles AB, Smith C, Errouane B, Damak H. [Assessment of frailty in the elderly and use of geriatric scores in emergencies]. Revue medicale suisse 2023. link 91 Jin Z, Rismany J, Gidicsin C, Bergese SD. Frailty: the perioperative and anesthesia challenges of an emerging pandemic. Journal of anesthesia 2023. link 92 Prasad R, Edwards J, Newton P, Gerbasi Rodrigues T, Curl C. Impact of a geriatric assessment and optimisation-based preoperative clinic on the management of older patients receiving dental treatment under general anaesthetic or conscious sedation: A service evaluation. Gerodontology 2023. link 93 Guaraldi G, Erlandson KM, Milic J, Landay AL, Montano MA. Can statin preventative treatment inform geroscience-guided therapeutics?. Aging cell 2023. link 94 Kuntz AA, Stumm EK, Anderson TC, Ibarra SJ, Markart MR, Haske-Palomino M. Use of a nursing-led geriatrics consult service to deliver age-friendly care. Geriatric nursing (New York, N.Y.) 2023. link 95 Conroy SP, van Oppen JD. Are we measuring what matters to older people?. The lancet. Healthy longevity 2023. link00084-3) 96 Hamaker M, Gijzel S, Rostoft S, van den Bos F. Intrinsic capacity and resilience: Taking frailty to the next level. Journal of geriatric oncology 2023. link 97 Dent E, Hanlon P, Sim M, Jylhävä J, Liu Z, Vetrano DL et al.. Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology. Ageing research reviews 2023. link 98 Gołębiowska J, Szymala-Pędzik M, Żórawska J, Sobieszczańska M, Agrawal S. Identification of Factors Affecting the Increased Percentage of CGA Recommendations among Patients on Geriatric Ward. International journal of environmental research and public health 2023. link 99 McCarthy L, Borley K, Ancelin T, Carroll R, Chadborn N, Blundell AG et al.. Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process. Age and ageing 2023. link 100 Pereira MJ, Chong E, Molina JAD, Ng SHX, Goh EF, Zhu B et al.. Evaluating Quality-of-Life, Length of Stay and Cost-Effectiveness of a Front-Door Geriatrics Program: An Exploratory Proof-of-Concept Study. The Journal of frailty & aging 2023. link