Overview
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology that can affect individuals of any age, sex, or ethnicity 1. The clinical presentation ranges from asymptomatic cases to acute liver failure with massive hepatocyte necrosis 1.Diagnosis
AIH is a chronic liver disease of unknown aetiology 1.
Clinical spectrum varies from asymptomatic to acute liver failure 1.
Neuroimmune signatures may predict disease severity 2.Management
Management guidance for AIH, including variants and specific forms, is provided 1.
Detailed guidance on managing AIH-associated cirrhosis is available, including surveillance for portal hypertension and hepatocellular carcinoma 1.
Liver transplantation is considered in decompensated cirrhosis 1.
Neuroimmune genes are implicated as potential therapeutic targets 2.Special Populations
Guidance is provided for both adults and children with AIH 1.Key Recommendations
Updated guidance on the diagnosis and management of AIH in adults and children is available 1. (Evidence: Expert opinion)
Management of AIH-associated cirrhosis, including surveillance for portal hypertension and hepatocellular carcinoma, is detailed 1. (Evidence: Expert opinion)
Liver transplantation is recommended for patients with decompensated cirrhosis 1. (Evidence: Expert opinion)
Neuroimmune signatures may serve as potential biomarkers and therapeutic targets in hepatitis 2. (Evidence: Moderate)References
1 . EASL Clinical Practice Guidelines on the management of autoimmune hepatitis. Journal of hepatology 2025. link
2 Nóbile AL, Adri AS, Usuda JN, Vale FYND, Corrêa YLG, Freitas DGA et al.. The Neuroimmunome of Hepatitis Patients Associates With Disease Severity. Journal of medical virology 2025. link