Pathophysiology
Increased COX-2 mRNA expression and secreted PGE2 levels were observed in rotavirus-infected Caco-2 cells, suggesting a potential role in the infection process [PMID:15331705].
Management
Indomethacin, which inhibits both COX-1 and COX-2, reduced rotavirus infection by 85% in Caco-2 cells, primarily by inhibiting virus protein synthesis without affecting viral RNA synthesis [PMID:15331705].
Key Recommendations
Given the significant reduction in rotavirus infection observed with COX inhibitors, further clinical trials exploring their use as adjunct therapies in rotavirus enteritis could be warranted [PMID:15331705]. (Evidence: Expert opinion)
References
1 Rossen JW, Bouma J, Raatgeep RH, Büller HA, Einerhand AW. Inhibition of cyclooxygenase activity reduces rotavirus infection at a postbinding step. Journal of virology 2004. link
1 papers cited of 3 indexed.