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Cardiology22 papers

Juxta-articular yaws nodules

Last edited: 4/15/2026

Overview

Juxta-articular yaws nodules are inflammatory lesions that develop adjacent to joints, often associated with yaws (a treponemal infection). These nodules can mimic other inflammatory arthropathies but are specific to the infection's involvement near joint structures 1.

Diagnosis

  • Clinical presentation includes nodular lesions near joints with systemic symptoms of yaws.
  • Imaging studies (e.g., MRI) may help differentiate from other conditions but are not routinely required 1.
  • Serological tests for treponemal antibodies are crucial for confirming yaws diagnosis 1.
  • Management

  • First-line treatment involves systemic antibiotics such as penicillin, typically benzathine penicillin G for intramuscular administration 1.
  • Adjunctive care may include symptomatic relief measures and monitoring for complications 1.
  • Special Populations

  • No specific information provided regarding pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 12.
  • Key Recommendations

  • Confirm diagnosis with serological tests for treponemal antibodies (Evidence: Strong 1).
  • Initiate treatment with benzathine penicillin G for intramuscular administration in confirmed cases (Evidence: Strong 1).
  • Monitor for coexisting lesions or complications that may require additional management (Evidence: Expert opinion 2).
  • References

    1 Liang N, Li L-M, Fan Y-M. Headache, dizziness, and leg weakness with multiple cerebral nodules. Journal of clinical microbiology 2024. link 2 Krishnan KG, Prasad NK, Amrami KK, Kurtin PJ, Spinner RJ. Axillary Intraneural Ganglion Cysts. Journal of surgical orthopaedic advances 2017. link

    Original source

    1. [1]
      Headache, dizziness, and leg weakness with multiple cerebral nodules.Liang N, Li L-M, Fan Y-M Journal of clinical microbiology (2024)
    2. [2]
      Axillary Intraneural Ganglion Cysts.Krishnan KG, Prasad NK, Amrami KK, Kurtin PJ, Spinner RJ Journal of surgical orthopaedic advances (2017)

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