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Otolaryngology (ENT)10 papers

Cyclical neutropenia

Last edited: 4/15/2026

Overview

Cyclical neutropenia is a rare hematological disorder characterized by periodic fluctuations in neutrophil counts, leading to recurrent infections, ulcerative stomatitis, fever, and malaise 1.

Diagnosis

  • Periodic oscillations in peripheral neutrophil levels, typically ranging from normal to neutropenic 1.
  • Clinical symptoms include ulcerative stomatitis, fever, malaise, and increased susceptibility to infections 1.
  • Diagnostic criteria often involve serial blood counts to demonstrate cyclical fluctuations 1.
  • Collaboration with hematologists is essential for accurate diagnosis 1.

    • Management

  • Regular monitoring of blood counts to guide treatment timing 1.
  • Prophylactic antibiotics to prevent infections during neutropenic periods 1.
  • G-CSF (granulocyte colony-stimulating factor) therapy may be used to boost neutrophil counts acutely 1.
  • Close multidisciplinary care involving hematologists and specialists (e.g., otolaryngologists) for managing complications 1.

    • Special Populations

  • No specific details provided regarding pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1.

    • Key Recommendations

  • Perform serial blood counts to confirm cyclical fluctuations in neutrophil levels for diagnosis (Evidence: Weak) 1.
  • Initiate prophylactic antibiotics during periods of neutropenia to prevent infections (Evidence: Weak) 1.
  • Consider G-CSF therapy for acute management of severe neutropenic episodes (Evidence: Weak) 1.

    • References

    1 Bandason C, Lee RJ. Fatal human cyclical neutropenia with unresolving tonsillitis and bilateral cervical abscesses. The Journal of laryngology and otology 1991. link

    Original source

    1. [1]
      Fatal human cyclical neutropenia with unresolving tonsillitis and bilateral cervical abscesses. — Bandason C, Lee RJ The Journal of laryngology and otology (1991)
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