Overview
Presenile dementia, also known as early-onset dementia, refers to dementia that begins before the age of 65. Depression is a common comorbidity in individuals with dementia and can also present with cognitive symptoms that may overlap with dementia.Diagnosis
Reduced autobiographical memory specificity and increased overgeneral autobiographical memory (OGM) have been observed in individuals with remitted major depression 1.
These memory deficits may persist following remission of depressive episodes and could be a risk factor for future depressive episodes 1.Management
No management strategies for presenile dementia with depression were covered in the provided abstracts.Special Populations
No information on special populations was covered in the provided abstracts.Key Recommendations
Reduced memory specificity and overgeneral memory persist following remission of depression and may be a risk factor for future depressive episodes 1. (Evidence: Moderate)
The persistence of reduced memory specificity/overgeneral memory following depression remission may influence clinical understanding of relapse prevention and maintenance of remission in individuals with a history of depression 1. (Evidence: Weak)References
1 Hallford DJ, Rusanov D, Yeow JJE, Barry TJ. Reduced specificity and increased overgenerality of autobiographical memory persist as cognitive vulnerabilities in remitted major depression: A meta-analysis. Clinical psychology & psychotherapy 2022. link