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Opioid dependence in remission

Last edited: 4/10/2026

Overview

Opioid dependence is a chronic relapsing brain disease characterized by compulsive drug seeking and use, despite harmful consequences 1. While associated with significant morbidity and mortality, its specific impact on cardiovascular health, such as myocardial infarction (MI), is an area of ongoing investigation 1.

Diagnosis

Management

  • Morphine dependency was significantly associated with MI 1.
  • The risk factors for MI, including hypertension, hyperlipidemia, and diabetes, were not significantly associated with morphine dependency 1.
  • Physicians should consider the presence of impurities in morphine-based opioids 1.

    • Special Populations

    Key Recommendations

  • Morphine dependency is significantly related to myocardial infarction 1. (Evidence: Moderate)
  • Hypertension, hyperlipidemia, and diabetes are not significantly associated with morphine dependency 1. (Evidence: Moderate)
  • Consider the presence of impurities in morphine-based opioids 1. (Evidence: Expert opinion)

    • References

    1 Rohani F, Rezayat AA, Zarifian A, Nour MG, Vakilian F, Sahebkar A et al.. Opioid Dependency and Myocardial Infarction: A Systematic Review and Meta-Analysis. Current reviews in clinical and experimental pharmacology 2021. link

    Original source

    1. [1]
      Opioid Dependency and Myocardial Infarction: A Systematic Review and Meta-Analysis. — Rohani F, Rezayat AA, Zarifian A, Nour MG, Vakilian F, Sahebkar A et al. Current reviews in clinical and experimental pharmacology (2021)
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